Zheng Y, Zhang LM, Zhao JG, Li LY, Wang MX, Gao PF, Wang Q, Zhang XL, Wang WZ (2022) Advances in aptamers against aβ and applications in aβ detection and regulation for alzheimer’s disease. Theranostics 12(5):2095–2114
Article CAS PubMed PubMed Central Google Scholar
John OO, Amarachi IS, Chinazom AP, Adaeze E, Kale MB, Umare MD, Upaganlawar AB (2022) Phytotherapy: a promising approach for the treatment of alzheimer’s disease. Pharmacol Res—Modern Chinese Med 2:100030–100041. https://doi.org/10.1016/j.prmcm.2021.100030
Scheltens P, De Strooper B, Kivipelto M, Holstege H, Chetelat G, Teunissen CE, Cummings J (2021) Alzheimer’s disease. Lancet 397(10284):1577–1590. https://doi.org/10.1016/S0140-6736(20)32205-4
Article CAS PubMed PubMed Central Google Scholar
Chen SY, Gao Y, Sun JY, Meng XL, Yang D, Fan LH, Xiang L, Wang P (2020) Traditional chinese medicine: Role in reducing beta-amyloid, apoptosis, autophagy, neuroinflammation, oxidative stress, and mitochondrial dysfunction of alzheimer’s disease. Front Pharmacol 11:497–516. https://doi.org/10.3389/fphar.2020.00497
Article CAS PubMed PubMed Central Google Scholar
Keren-Kaplan T, Attali I, Estrin M, Kuo LS, Farkash E, Jerabek-Willemsen M, Blutraich N, Artzi S, Peri A, Freed EO, Wolfson HJ, Prag G (2013) Structure-based in silico identification of ubiquitin-binding domains provides insights into the alix-v: ubiquitin complex and retrovirus budding. EMBO J 32(4):538–551. https://doi.org/10.1038/emboj.2013.4
Article CAS PubMed PubMed Central Google Scholar
Gaugler J et al (2022) 2022 alzheimer’s disease facts and figures. Alzheimers Dement 18(4):700–789
Ising C, Venegas C, Zhang S, Scheiblich H, Schmidt SV, Vieira-Saecker A, Schwartz S, Albasset S, McManus RM, Tejera D, Griep A, Santarelli F, Brosseron F, Opitz S, Stunden J, Merten M, Kayed R, Golenbock DT, Blum D, Latz E, Buee L, Heneka MT (2019) Nlrp3 inflammasome activation drives tau pathology. Nature 575(7784):669–673. https://doi.org/10.1038/s41586-019-1769-z
Article CAS PubMed PubMed Central Google Scholar
Guo TT, Zhang DH, Zeng YZ, Huang TY, Xu HX, Zhao YJ (2020) Molecular and cellular mechanisms underlying the pathogenesis of alzheimer’s disease. Mol Neurodegener 15(1):40–77. https://doi.org/10.1186/s13024-020-00391-7
Article PubMed PubMed Central Google Scholar
Ding MR, Qu YJ, Hu B, An HM (2022) Signal pathways in the treatment of alzheimer’s disease with traditional chinese medicine. Biomed Pharmacother 152:113208–113223. https://doi.org/10.1016/j.biopha.2022.113208
Fish PV, Steadman D, Bayle ED, Whiting P (2019) New approaches for the treatment of alzheimer’s disease. Bioorg Med Chem Lett 29(2):125–133. https://doi.org/10.1016/j.bmcl.2018.11.034
Article CAS PubMed Google Scholar
Fink HA, Linskens EJ, MacDonald R, Silverman PC, McCarten JR, Talley KMC, Forte ML, Desai PJ, Nelson VA, Miller MA, Hemmy LS, Brasure M, Taylor BC, Ng W, Ouellette JM, Sheets KM, Wilt TJ, Butler M (2020) Benefits and harms of prescription drugs and supplements for treatment of clinical alzheimer-type dementia. Ann Intern Med 172(10):656–668. https://doi.org/10.7326/M19-3887
Lancet T (2022) Lecanemab for alzheimer’s disease: tempering hype and hope. Lancet 400(10367):1899. https://doi.org/10.1016/S0140-6736(22)02480-1
Swanson CJ, Zhang Y, Dhadda S, Wang J, Kaplow J, Lai RYK, Lannfelt L, Bradley H, Rabe M, Koyama A, Reyderman L, Berry DA, Berry S, Gordon R, Kramer LD, Cummings JL (2021) A randomized, double-blind, phase 2b proof-of-concept clinical trial in early alzheimer’s disease with lecanemab, an anti-abeta protofibril antibody. Alzheimers Res Ther 13(1):80–94. https://doi.org/10.1186/s13195-021-00813-8
Article CAS PubMed PubMed Central Google Scholar
Atwood CS, Perry G (2023) Playing russian roulette with alzheimer’s disease patients: Do the cognitive benefits of lecanemab outweigh the risk of edema, stroke and encephalitis? J Alzheimers Dis 92(3):799–801
Thakral S, Yadav A, Singh V, Kumar M, Kumar P, Narang R, Sudhakar K, Verma A, Khalilullah H, Jaremko M, Emwas AH (2023) Alzheimer’s disease: molecular aspects and treatment opportunities using herbal drugs. Ageing Res Rev 88:101960–101995. https://doi.org/10.1016/j.arr.2023.101960
Article CAS PubMed Google Scholar
Liao S, Han LW, Zheng XP, Wang X, Zhang P, Wu JN, Liu RM, Fu YL, Sun JX, Kang XM, Liu KC, Fan TP, Li S, Zheng XH (2019) Tanshinol borneol ester, a novel synthetic small molecule angiogenesis stimulator inspired by botanical formulations for angina pectoris. Br J Pharmacol 176(17):3143–3160. https://doi.org/10.1111/bph.14714
Article CAS PubMed PubMed Central Google Scholar
Yin Q, Lu HY, Bai YJ, Tian AJ, Yang QX, Wu JM, Yang CZ, Fan TP, Zhang YY, Zheng XH, Zheng XP, Li ZJ (2015) A metabolite of danshen formulae attenuates cardiac fibrosis induced by isoprenaline, via a nox2/ros/p38 pathway. Br J Pharmacol 172(23):5573–5585. https://doi.org/10.1111/bph.13133
Article CAS PubMed PubMed Central Google Scholar
Yang CZ, Wang SH, Zhang RH, Lin JH, Tian YH, Yang YQ, Liu J, Ma YX (2023) Neuroprotective effect of astragalin via activating pi3k/akt-mtor-mediated autophagy on app/ps1 mice. Cell Death Discov 9(1):15–28. https://doi.org/10.1038/s41420-023-01324-1
Article CAS PubMed PubMed Central Google Scholar
Durairajan SSK, Iyaswamy A, Shetty SG, Kammella AK, Malampati S, Shang W, Yang C, Song J, Chung S, Huang J, Ilango K, Han QB, Li M (2017) A modified formulation of huanglian-jie-du-tang reduces memory impairments and beta-amyloid plaques in a triple transgenic mouse model of alzheimer’s disease. Sci Rep 7(1):6238–6251. https://doi.org/10.1038/s41598-017-06217-9
Article CAS PubMed PubMed Central Google Scholar
Liu LF, Song JX, Lu JH, Huang YY, Zeng Y, Chen LL, Durairajan SS, Han QB, Li M (2015) Tianma gouteng yin, a traditional chinese medicine decoction, exerts neuroprotective effects in animal and cellular models of parkinson’s disease. Sci Rep 5:16862–16873. https://doi.org/10.1038/srep16862
Article CAS PubMed PubMed Central Google Scholar
Wei BB, Liu MY, Chen ZX, Wei MJ (2018) Schisandrin ameliorates cognitive impairment and attenuates abeta deposition in app/ps1 transgenic mice: involvement of adjusting neurotransmitters and their metabolite changes in the brain. Acta Pharmacol Sin 39(4):616–625. https://doi.org/10.1038/aps.2017.135
Article CAS PubMed PubMed Central Google Scholar
Fang ZL, Tang YQ, Ying JM, Tang CL, Wang QW (2020) Traditional chinese medicine for anti-alzheimer’s disease: berberine and evodiamine from evodia rutaecarpa. Chinese Medicine 15(1):82–98. https://doi.org/10.1186/s13020-020-00359-1
Article CAS PubMed PubMed Central Google Scholar
Zhou H, Hou YJ, Wang Y, Zhao J, Li XH, Cui J, Ding JQ, Wang Y, ZengXL LY, Shen XH, Chen SD, Huang CG, Pei G (2014) Smart soup, a traditional chinese medicine formula, ameliorates amyloid pathology and related cognitive deficits. PLoS ONE 9(11):111215–111228. https://doi.org/10.1371/journal.pone.0237035
Jia YJ, Wang J, Hou YL (2020) A meta-analysis of the effectiveness of yangxue qingnao granules for the treatment of chronic cerebral circulation insufficiency. Brain and Behavior 10(5):1–10. https://doi.org/10.1002/brb3.1606
Zhang YY, Guo KM, Zhang PF, Zhang MY, Li XQ, Zhou SP, Sun H, Wang WJ, Wang H, Hu YH (2022) Exploring the mechanism of yangxue qingnao wan based on network pharmacology in the treatment of alzheimer’s disease. Front Genet 13:942203–942218. https://doi.org/10.3389/fgene.2022.942203
Article CAS PubMed PubMed Central Google Scholar
Pei H, Ma L, Cao Y, Wang FX, Li ZH, Liu NY, Liu MX, Wei Y, Li H (2020) Traditional chinese medicine for alzheimer’s disease and other cognitive impairment: a review. Am J Chin Med 48(03):487–511. https://doi.org/10.1142/S0192415X20500251
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