EBMT, endoscopic bariatric and metabolic therapy; TWL, total weight loss; EWL, excess weight loss; SAE, severe adverse event; DJBL, duodenaljejunal bypass liner; T2DM, type 2 diabetes mellitus; IGB, intragastric balloon; FDA, Food and Drug Administration; ESG, endoscopic sleeve gastroplasty; RCT, randomized controlled trial; POSE, primary obesity surgery endoluminal; DMR, duodenal mucosal resurfacing; NAFLD, non-alcoholic fatty liver disease.