Fig. 1. The AQ-Flex 19-needle confocal laser endomicroscopy miniprobe (Cellvizio AQ-Flex 19 miniprobe; Mauna Kea Technologies).

Fig. 2. (a) The ferrule is a metallic tap at the distal end of the probe that protects the device from the beveled needle tip. (b) The sheath of the probe comprises a robust, protective, biocompatible coating. (c) A locking device is attached by a Luer lock on the fine needle aspiration needle’s proximal hub and is secured onto the probe to maintain needle position and prevent migration.

Fig. 3. A schema of endoscopic ultrasound-guided needle-based confocal laser endomicroscopy (nCLE) being performed for a pancreatic cystic lesion. Black: duodenoscope; blue: 19G FNA needle; red: nCLE miniprobe; gray circle: pancreatic cyst.

Fig. 4. The superficial vascular network is seen on needle-based confocal laser endomicroscopy of a serous cystadenoma. Arrows indicate blood vessels forming a superficial vascular network.

Fig. 5. Papillary projections characterized by a vascular core (in white, indicated by arrows) surrounded by an epithelial border (in gray) are seen on needle-based confocal laser endomicroscopy of an intraductal papillary mucinous neoplasm.

Fig. 6. A thick epithelial band (indicated by an arrow) is seen on needle-based confocal laser endomicroscopy of a mucinous cystadenoma.

Fig. 7. Bright uniform particles are seen against a dark background on needle-based confocal laser endomicroscopy of a pseudocyst.