Almagro Armenteros JJ, Tsirigos KD, Sonderby CK, Petersen TN, Winther O, Brunak S, von Heijne G, Nielsen H (2019) SignalP 5.0 improves signal peptide predictions using deep neural networks. Nat Biotechnol 37:420–423

Article  CAS  PubMed  Google Scholar 

Alzahrani N, Wu MJ, Shanmugam S, Yi M (2020) Delayed by design: role of suboptimal signal peptidase processing of viral structural protein precursors in Flaviviridae virus assembly. Viruses 12:1090

Article  CAS  PubMed  PubMed Central  Google Scholar 

Avci D, Fuchs S, Schrul B, Fukumori A, Breker M, Frumkin I, Chen CY, Biniossek ML, Kremmer E, Schilling O, Steiner H, Schuldiner M, Lemberg MK (2014) The yeast ER-intramembrane protease Ypf1 refines nutrient sensing by regulating transporter abundance. Mol Cell 56:630–640

Article  CAS  PubMed  Google Scholar 

Bachmair A, Finley D, Varshavsky A (1986) In vivo half-life of a protein is a function of its amino-terminal residue. Science 234:179–186

Article  CAS  PubMed  Google Scholar 

Berninsone P, Miret JJ, Hirschberg CB (1994) The Golgi guanosine diphosphatase is required for transport of GDP-mannose into the lumen of Saccharomyces cerevisiae Golgi vesicles. J Biol Chem 269:207–211

Article  CAS  PubMed  Google Scholar 

Christianson JC, Jarosch E, Sommer T (2023) Mechanisms of substrate processing during ER-associated protein degradation. Nat Rev Mol Cell Biol 24:777–796

Article  CAS  PubMed  Google Scholar 

Donella-Deana A, Ostojic S, Pinna LA, Barbaric S (1993) Specific dephosphorylation of phosphopeptides by the yeast alkaline phosphatase encoded by PHO8 gene. Biochim Biophys Acta 1177:221–228

Article  CAS  PubMed  Google Scholar 

Falk MM, Kumar NM, Gilula NB (1994) Membrane insertion of gap junction connexins: polytopic channel forming membrane proteins. J Cell Biol 127:343–355

Article  CAS  PubMed  Google Scholar 

Fang H, Mullins C, Green N (1997) In addition to SEC11, a newly identified gene, SPC3, is essential for signal peptidase activity in the yeast endoplasmic reticulum. J Biol Chem 272:13152–13158

Article  CAS  PubMed  Google Scholar 

Gowen BG, Chim B, Marceau CD, Greene TT, Burr P, Gonzalez JR, Hesser CR, Dietzen PA, Russell T, Iannello A, Coscoy L, Sentman CL, Carette JE, Muljo SA, Raulet DH (2015) A forward genetic screen reveals novel independent regulators of ULBP1, an activating ligand for natural killer cells. Elife 4:e08474

Article  PubMed  PubMed Central  Google Scholar 

Krshnan L, van de Weijer ML, Carvalho P (2022) Endoplasmic reticulum-associated protein degradation. Cold Spring Harb Perspect Biol 14:a041247

Article  CAS  PubMed  Google Scholar 

Lara P, Tellgren-Roth A, Behesti H, Horn Z, Schiller N, Enquist K, Cammenberg M, Liljenstrom A, Hatten ME, von Heijne G, Nilsson I (2019) Murine astrotactins 1 and 2 have a similar membrane topology and mature via endoproteolytic cleavage catalyzed by a signal peptidase. J Biol Chem 294:4538–4545

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liaci AM, Steigenberger B, Telles de Souza PC, Tamara S, Grollers-Mulderij M, Ogrissek P, Marrink SJ, Scheltema RA, Forster F (2021) Structure of the human signal peptidase complex reveals the determinants for signal peptide cleavage. Mol Cell 81(3934–48):e11

Google Scholar 

Longtine MS, McKenzie A 3rd, Demarini DJ, Shah NG, Wach A, Brachat A, Philippsen P, Pringle JR (1998) Additional modules for versatile and economical PCR-based gene deletion and modification in Saccharomyces cerevisiae. Yeast 14:953–961

Article  CAS  PubMed  Google Scholar 

Lussier M, Sdicu AM, Bussereau F, Jacquet M, Bussey H (1997) The Ktr1p, Ktr3p, and Kre2p/Mnt1p mannosyltransferases participate in the elaboration of yeast O- and N-linked carbohydrate chains. J Biol Chem 272:15527–15531

Article  CAS  PubMed  Google Scholar 

Mallet L, Bussereau F, Jacquet M (1994) Nucleotide sequence analysis of an 11.7 kb fragment of yeast chromosome II including BEM1, a new gene of the WD-40 repeat family and a new member of the KRE2/MNT1 family. Yeast 10:819–831

Article  CAS  PubMed  Google Scholar 

Marini AM, Soussi-Boudekou S, Vissers S, Andre B (1997) A family of ammonium transporters in Saccharomyces cerevisiae. Mol Cell Biol 17:4282–4293

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mullins C, Meyer HA, Hartmann E, Green N, Fang H (1996) Structurally related Spc1p and Spc2p of yeast signal peptidase complex are functionally distinct. J Biol Chem 271:29094–29099

Article  CAS  PubMed  Google Scholar 

Navarre C, Ghislain M, Leterme S, Ferroud C, Dufour JP, Goffeau A (1992) Purification and complete sequence of a small proteolipid associated with the plasma membrane H(+)-ATPase of Saccharomyces cerevisiae. J Biol Chem 267:6425–6428

Article  CAS  PubMed  Google Scholar 

Otte S, Belden WJ, Heidtman M, Liu J, Jensen ON, Barlowe C (2001) Erv41p and Erv46p: new components of COPII vesicles involved in transport between the ER and Golgi complex. J Cell Biol 152:503–518

Article  CAS  PubMed  PubMed Central  Google Scholar 

Petersen TN, Brunak S, von Heijne G, Nielsen H (2011) SignalP 4.0: discriminating signal peptides from transmembrane regions. Nat Methods 8:785–786

Article  CAS  PubMed  Google Scholar 

Printsev I, Curiel D, Carraway KL 3rd (2017) Membrane protein quantity control at the endoplasmic reticulum. J Membr Biol 250:379–392

Article  CAS  PubMed  Google Scholar 

Reggiori F, Pelham HR (2001) Sorting of proteins into multivesicular bodies: ubiquitin-dependent and -independent targeting. EMBO J 20:5176–5186

Article  CAS  PubMed  PubMed Central  Google Scholar 

Schubert U, Anton LC, Gibbs J, Norbury CC, Yewdell JW, Bennink JR (2000) Rapid degradation of a large fraction of newly synthesized proteins by proteasomes. Nature 404:770–774

Article  CAS  PubMed  Google Scholar 

Tsirigos KD, Peters C, Shu N, Kall L, Elofsson A (2015) The TOPCONS web server for consensus prediction of membrane protein topology and signal peptides. Nucleic Acids Res 43:W401–W407

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yim C, Chung Y, Kim J, Nilsson I, Kim JS, Kim H (2021) Spc1 regulates the signal peptidase-mediated processing of membrane proteins. J Cell Sci 134:jcs258936

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zanotti A, Coelho JPL, Kaylani D, Singh G, Tauber M, Hitzenberger M, Avci D, Zacharias M, Russell RB, Lemberg MK, Feige MJ (2022) The human signal peptidase complex acts as a quality control enzyme for membrane proteins. Science 378:996–1000

Article  CAS  PubMed  Google Scholar 

Zhang R, Miner JJ, Gorman MJ, Rausch K, Ramage H, White JP, Zuiani A, Zhang P, Fernandez E, Zhang Q, Dowd KA, Pierson TC, Cherry S, Diamond MS (2016) A CRISPR screen defines a signal peptide processing pathway required by flaviviruses. Nature 535:164–168

Article  CAS  PubMed  PubMed Central  Google Scholar