Aggregation Behavior of Amyloid Beta Peptide Depends Upon the Membrane Lipid Composition

Agarwal M, Khan S (2020) Plasma lipids as biomarkers for Alzheimer’s disease: a systematic review. Cureus 12:12008

Google Scholar 

Bailey CC, DeVaux LB, Farzan M (2015) The triggering receptor expressed on myeloid cells 2 binds apolipoprotein E. J Biol Chem 290:26033–26042

Article  CAS  PubMed  PubMed Central  Google Scholar 

Banerjee S, Hashemi M, Zagorski K, Lyubchenko YL (2021) Cholesterol in membranes facilitates aggregation of amyloid β protein at physiologically relevant concentrations. ACS Chem Neurosci 12:506–516

Article  CAS  PubMed  Google Scholar 

Barrett PJ, Song Y, Van Horn WD, Hustedt EJ, Schafer JM, Hadziselimovic A, Beel AJ, Sanders CR (2012) The amyloid precursor protein has a flexible transmembrane domain and binds cholesterol. Science 336:1168–1171

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bassett CN, Montine TJ (2003) Lipoproteins and lipid peroxidation in Alzheimer’s disease. J Nutr Health Aging 7:24–29

CAS  PubMed  Google Scholar 

Bedse G, Romano A, Lavecchia AM, Cassano T, Gaetani S (2015) The role of endocannabinoid signaling in the molecular mechanisms of neurodegeneration in Alzheimer’s disease. J Alzheimers Dis 43:1115–1136

Article  CAS  PubMed  Google Scholar 

Belayev L, Hong SH, Menghani H, Marcell SJ, Obenaus A, Freitas RS, Khoutorova L, Balaszczuk V, Jun B, Oriá RB, Bazan NG (2018) Docosanoids promote neurogenesis and angiogenesis, blood-brain barrier integrity, penumbra protection, and neurobehavioral recovery after experimental ischemic stroke. Mol Neurobiol 55:7090–7106

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bhattacharyya R, Barren C, Kovacs DM (2013) Palmitoylation of amyloid precursor protein regulates amyloidogenic processing in lipid rafts. J Neurosci 33:11169–11183

Article  CAS  PubMed  PubMed Central  Google Scholar 

Biringer RG (2019) The Role of Eicosanoids in Alzheimer’s disease. Int J Environ Res Public Health 16:2560

Article  CAS  PubMed  PubMed Central  Google Scholar 

Björkhem I, Meaney S (2004) Brain cholesterol: long secret life behind a barrier. Arterioscler Thromb Vasc Biol 24:806–815

Article  PubMed  Google Scholar 

Bode DC, Baker MD, Viles JH (2017) Ion channel formation by amyloid-β42 oligomers but not amyloid-β40 in cellular membranes. J Biol Chem 292:1404–1413

Article  CAS  PubMed  Google Scholar 

Bokvist M, Lindström F, Watts A, Gröbner G (2004) Two types of Alzheimer’s beta-amyloid (1–40) peptide membrane interactions: aggregation preventing transmembrane anchoring versus accelerated surface fibril formation. J Mol Biol 335:1039–1049

Article  CAS  PubMed  Google Scholar 

Bolognin S, Messori L, Drago D, Gabbiani C, Cendron L, Zatta P (2011) Aluminum, copper, iron and zinc differentially alter amyloid-Aβ(1–42) aggregation and toxicity. Int J Biochem Cell Biol 43:877–885

Article  CAS  PubMed  Google Scholar 

Bucciantini M, Rigacci S, Stefani M (2014) Amyloid aggregation: role of biological membranes and the aggregate-membrane system. J Phys Chem Lett 5:517–527

Article  CAS  PubMed  Google Scholar 

Cai M, Zhang X, He W, Zhang J (2020) The involvement of metals in Alzheimer’s disease through epigenetic mechanisms. Front Genet 11:614666

Article  CAS  PubMed  PubMed Central  Google Scholar 

Carrotta R, Mangione MR, Librizzi F, Moran O (2021) Small angle X-ray scattering sensing membrane composition: the role of sphingolipids in membrane-amyloid β-peptide interaction. Biology (basel) 11:26

PubMed  Google Scholar 

Castellano JM, Kim J, Stewart FR, Jiang H, DeMattos RB, Patterson BW, Fagan AM, Morris JC, Mawuenyega KG, Cruchaga C, Goate AM, Bales KR, Paul SM, Bateman RJ, Holtzman DM (2011) Human apoE isoforms differentially regulate brain amyloid-β peptide clearance. Sci Transl Med 3:8957–8957

Article  Google Scholar 

Catalá A, Díaz M (2016) Editorial: impact of lipid peroxidation on the physiology and pathophysiology of cell membranes. Front Physiol 7:423

Article  PubMed  PubMed Central  Google Scholar 

Chang JY, Chavis JA, Liu LZ, Drew PD (1998) Cholesterol oxides induce programmed cell death in microglial cells. Biochem Biophys Res Commun 249:817–821

Article  CAS  PubMed  Google Scholar 

Chang TY, Yamauchi Y, Hasan MT, Chang C (2017) Cellular cholesterol homeostasis and Alzheimer’s disease. J Lipid Res 58:2239–2254

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chappus-McCendie H, Chevalier L, Roberge C, Plourde M (2019) Omega-3 PUFA metabolism and brain modifications during aging. Prog Neuropsychopharmacol Biol Psychiatry 94:109662

Article  CAS  PubMed  Google Scholar 

Chaurio RA, Janko C, Muñoz LE, Frey B, Herrmann M, Gaipl US (2009) Phospholipids: key players in apoptosis and immune regulation. Molecules 14:4892–4914

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen J, Wei Y, Chen X, Jiao J, Zhang Y (2017) Polyunsaturated fatty acids ameliorate aging via redox-telomere-antioncogene axis. Oncotarget 8:7301–7314

Article  PubMed  Google Scholar 

Chen L-L, Fan Y-G, Zhao L-X, Zhang Q, Wang Z-Y (2023) The metal ion hypothesis of Alzheimer’s disease and the anti-neuroinflammatory effect of metal chelators. Bioorg Chem 131:106301

Article  CAS  PubMed  Google Scholar 

Chew H, Solomon VA, Fonteh AN (2020) Involvement of lipids in Alzheimer’s disease pathology and potential therapies. Front Physiol 11:598

Article  PubMed  PubMed Central  Google Scholar 

Cho WJ, Jena BP, Jeremic AM (2008) Chapter 13 nano-scale imaging and dynamics of amylin-membrane interactions and its implication in type II diabetes mellitus. Methods Cell Biol 90:267–286

Article  CAS  PubMed  Google Scholar 

Colonna M, Wang Y (2016) TREM2 variants: new keys to decipher Alzheimer disease pathogenesis. Nat Rev Neurosci 17:201–207

Article  CAS  PubMed  Google Scholar 

Cossec JC, Marquer C, Panchal M, Lazar AN, Duyckaerts C, Potier MC (2010) Cholesterol changes in Alzheimer’s disease: methods of analysis and impact on the formation of enlarged endosomes. Biochim Biophys Acta 1801:839–845

Article  CAS  PubMed  Google Scholar 

Cunnane SC, Schneider JA, Tangney C, Tremblay-Mercier J, Fortier M, Bennett DA, Morris MC (2012) Plasma and brain fatty acid profiles in mild cognitive impairment and Alzheimer’s disease. J Alzheimers Dis 29:691–697

Article  CAS  PubMed  PubMed Central  Google Scholar 

Daiello LA, Gongvatana A, Dunsiger S, Cohen RA, Ott BR (2015) Association of fish oil supplement use with preservation of brain volume and cognitive function. Alzheimers Dement 11:226–235

Article  PubMed  Google Scholar 

Dante S, Hauss T, Dencher NA (2006) Cholesterol inhibits the insertion of the Alzheimer’s peptide Abeta(25–35) in lipid bilayers. Eur Biophys J 35:523–531

Article  CAS  PubMed 

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