Populist attitudes are multi-causal, but their determinants are often studied separately, in small groups, or in different samples. This study presents a comprehensive model for the prediction of populist attitudes using a single sample. We use an ideological approach and measure of populist attitudes as anti-elitism, popular sovereignty, and homogeneity, while the differences between the elite and the people are Manichean. Analyzing a sample based on a representative quota for gender, age, education and region of Slovakia (N = 254), it was found that relative deprivation, belief in simple solutions, external political efficacy, trust towards experts, and conspiracy mentality were significant predictors of populist attitudes after controlling for other variables. The effect of education and subjective income faded out after adding variables into the model. The model explained 54% of the variance in populist attitudes. The results are discussed in detail with respect to its limitations and country specifics.