Franklin RM, Kenyon KR, Tutschka PJ, Saral R, Richard Green W, Santos GW. Ocular manifestations of graft-vs-host disease. Ophthalmology. 1983;90:4–13. https://doi.org/10.1016/S0161-6420(83)34604-2.
Article CAS PubMed Google Scholar
Pellegrini M, Bernabei F, Barbato F, Arpinati M, Giannaccare G, Versura P, et al. Incidence, risk factors and complications of ocular graft-versus-host disease following hematopoietic stem cell transplantation. Am J Ophthalmol. 2021;227:25–34. https://doi.org/10.1016/J.AJO.2021.02.022.
Bray LC, Carey PJ, Proctor SJ, Evans RGB, Hamilton PJ, Carey TPJ. Ocular complications of bone marrow transplantation. Britishlournal Ophthalmol. 1991;75:611–4.
Anderson NG, Regillo C. Ocular manifestations of graft versus host disease. Curr Opin Ophthalmol. 2004;15:503–7. https://doi.org/10.1097/01.ICU.0000143684.22362.46.
Sinha S, Singh RB, Dohlman TH, Taketani Y, Yin J, Dana R. Prevalence and risk factors associated with corneal perforation in chronic ocular graft-versus-host-disease. Cornea. 2020. https://doi.org/10.1097/ICO.0000000000002526.
Sinha S, Singh RB, Dohlman TH, Wang M, Taketani Y, Yin J, et al. Prevalence of persistent corneal epithelial defects in chronic ocular graft-versus-host disease. Am J Ophthalmol. 2020;218:296–303. https://doi.org/10.1016/j.ajo.2020.05.035.
Singh RB, Yuksel E, Sinha S, Wang S, Taketani Y, Luznik Z, et al. Prevalence of neurotrophic keratopathy in patients with chronic ocular graft-versus-host disease. Ocul Surf. 2022;26:13–8. https://doi.org/10.1016/j.jtos.2022.07.001.
Wang S, Singh RB, Yuksel E, Musayeva A, Sinha S, Taketani Y, et al. Ocular pain in ocular graft-versus-host disease patients with neurotrophic keratopathy. Ocul Surf. 2022;26:142–7. https://doi.org/10.1016/J.JTOS.2022.07.005.
Chen Y, Wang S, Alemi H, Dohlman T, Dana R. Immune regulation of the ocular surface. Exp Eye Res. 2022;218:109007 https://doi.org/10.1016/J.EXER.2022.109007.
Article CAS PubMed PubMed Central Google Scholar
Foulsham W, Coco G, Amouzegar A, Chauhan SK, Dana R. When clarity is crucial: regulating ocular surface immunity. Trends Immunol. 2018;39:288–301.
Article CAS PubMed Google Scholar
Jagasia M, Arora M, Flowers MED, Chao NJ, McCarthy PL, Cutler CS, et al. Risk factors for acute GVHD and survival after hematopoietic cell transplantation. Blood. 2012;119:296 https://doi.org/10.1182/BLOOD-2011-06-364265.
Article CAS PubMed PubMed Central Google Scholar
Flowers MED, Inamoto Y, Carpenter PA, Lee SJ, Kiem HP, Petersdorf EW, et al. Comparative analysis of risk factors for acute graft-versus-host disease and for chronic graft-versus-host disease according to National Institutes of Health consensus criteria. Blood. 2011;117:3214 https://doi.org/10.1182/BLOOD-2010-08-302109.
Article CAS PubMed PubMed Central Google Scholar
Hill GR, Ferrara JLM. The primacy of the gastrointestinal tract as a target organ of acute graft-versus-host disease: rationale for the use of cytokine shields in allogeneic bone marrow transplantation. Blood. 2000;95:2754–9. https://doi.org/10.1182/BLOOD.V95.9.2754.009K25_2754_2759.
Article CAS PubMed Google Scholar
Carapito R, Jung N, Kwemou M, Untrau M, Michel S, Pichot A, et al. Matching for the nonconventional MHC-I MICA gene significantly reduces the incidence of acute and chronic GVHD. Blood. 2016;128:1979–86. https://doi.org/10.1182/BLOOD-2016-05-719070.
Article CAS PubMed PubMed Central Google Scholar
Martin PJ, Levine DM, Storer BE, Warren EH, Zheng X, Nelson SC, et al. Genome-wide minor histocompatibility matching as related to the risk of graft-versus-host disease. Blood. 2017;129:791–8. https://doi.org/10.1182/BLOOD-2016-09-737700.
Article CAS PubMed PubMed Central Google Scholar
Klämbt V, Wohlfeil SA, Schwab L, Hülsdünker J, Ayata K, Apostolova P, et al. A novel function for P2Y2 in myeloid recipient-derived cells during graft-versus-host disease. J Immunol. 2015;195:5795–804. https://doi.org/10.4049/JIMMUNOL.1501357.
Reinhardt K, Foell D, Vogl T, Mezger M, Wittkowski H, Fend F, et al. Monocyte-induced development of Th17 cells and the release of S100 proteins are involved in the pathogenesis of graft-versus-host disease. J Immunol. 2014;193:3355–65. https://doi.org/10.4049/JIMMUNOL.1400983.
Article CAS PubMed Google Scholar
Arafat SN, Robert MC, Abud T, Spurr-Michaud S, Amparo F, Dohlman CH, et al. Elevated neutrophil elastase in tears of ocular graft-versus-host disease patients. Am J Ophthalmol. 2017;176:46–52. https://doi.org/10.1016/J.AJO.2016.12.026.
Article CAS PubMed Google Scholar
Mittal SK, Mashaghi A, Amouzegar A, Li M, Foulsham W, Sahu SK, et al. Mesenchymal stromal cells inhibit neutrophil effector functions in a murine model of ocular inflammation. Invest Ophthalmol Vis Sci. 2018;59:1191–8. https://doi.org/10.1167/iovs.17-23067.
Article CAS PubMed PubMed Central Google Scholar
Kolaczkowska E, Kubes P. Neutrophil recruitment and function in health and inflammation. Nat Rev Immunol. 2013;13:159–75. https://doi.org/10.1038/nri3399.
Article CAS PubMed Google Scholar
Hülsdünker J, Ottmüller KJ, Neeff HP, Koyama M, Gao Z, Thomas OS, et al. Neutrophils provide cellular communication between ileum and mesenteric lymph nodes at graft-versus-host disease onset. Blood. 2018;131:1858 https://doi.org/10.1182/BLOOD-2017-10-812891.
Article PubMed PubMed Central Google Scholar
An S, Raju I, Surenkhuu B, Kwon JE, Gulati S, Karaman M, et al. Neutrophil extracellular traps (NETs) contribute to pathological changes of ocular graft-vs.-host disease (oGVHD) dry eye: Implications for novel biomarkers and therapeutic strategies. Ocul Surf. 2019;17:589–614. https://doi.org/10.1016/J.JTOS.2019.03.010.
Article PubMed PubMed Central Google Scholar
Byun YS, Yoo YS, Kang MJ, Whang WJ, Na KS, Mok JW, et al. Marked infiltration of neutrophils at the upper palpebral conjunctiva in patients with chronic graft-versus-host disease. Ocul Surf. 2019;17:295–302. https://doi.org/10.1016/J.JTOS.2018.12.007.
Shikari H, Antin JH, Dana R. Ocular graft-versus-host disease: a review. Surv Ophthalmol. 2013;58:233–51. https://doi.org/10.1016/J.SURVOPHTHAL.2012.08.004.
Duffner UA, Maeda Y, Cooke KR, Reddy P, Ordemann R, Liu C, et al. Host dendritic cells alone are sufficient to initiate acute graft-versus-host disease. J Immunol. 2004;172:7393–8. https://doi.org/10.4049/JIMMUNOL.172.12.7393.
Article CAS PubMed Google Scholar
Stenger EO, Turnquist HR, Mapara MY, Thomson AW. Dendritic cells and regulation of graft-versus-host disease and graft-versus-leukemia activity. Blood. 2012;119:5088 https://doi.org/10.1182/BLOOD-2011-11-364091.
Article CAS PubMed PubMed Central Google Scholar
Li H, Demetris AJ, McNiff J, Matte-Martone C, Tan HS, Rothstein DM, et al. Profound depletion of host conventional dendritic cells, plasmacytoid dendritic cells, and B cells does not prevent graft-versus-host disease induction. J Immunol. 2012;188:3804–11. https://doi.org/10.4049/JIMMUNOL.1102795.
Article CAS PubMed Google Scholar
Shimabukuro-Vornhagen A, Hallek MJ, Storb RF, von Bergwelt-Baildon MS. The role of B cells in the pathogenesis of graft-versus-host disease. Blood. 2009;114:4919–27. https://doi.org/10.1182/BLOOD-2008-10-161638.
Zeiser R, Blazar BR. Acute graft-versus-host disease—biologic process, prevention, and therapy. N Engl J Med. 2017;377:2167–79. https://doi.org/10.1056/NEJMRA1609337/SUPPL_FILE/NEJMRA1609337_DISCLOSURES.PDF.
Article CAS PubMed PubMed Central Google Scholar
Toubai T, Mathewson ND, Magenau J, Reddy P. Danger signals and graft-versus-host disease: current understanding and future perspectives. Front Immunol. 2016;7. https://doi.org/10.3389/FIMMU.2016.00539.
Babelova A, Moreth K, Tsalastra-Greul W, Zeng-Brouwers J, Eickelberg O, Young MF, et al. Biglycan, a danger signal that activates the NLRP3 inflammasome via toll-like and P2X receptors. J Biol Chem. 2009;284:24035–48. https://doi.org/10.1074/JBC.M109.014266.
Article CAS PubMed PubMed Central Google Scholar
Koyama M, Cheong M, Markey KA, Gartlan KH, Kuns RD, Locke KR, et al. Donor colonic CD103+ dendritic cells determine the severity of acute graft-versus-host disease. J Exp Med. 2015;212:1303–21. https://doi.org/10.1084/JEM.20150329.
Article CAS PubMed PubMed Central Google Scholar
Zilliox MJ, Gange WS, Kuffel G, Mores CR, Joyce C, de Bustros P, et al. Assessing the ocular surface microbiome in severe ocular surface diseases. Ocul Surf. 2020;18:706–12. https://doi.org/10.1016/J.JTOS.2020.07.007.
Article PubMed PubMed Central Google Scholar
Riemens A, Stoyanova E, Rothova A, Kuiper J. Cytokines in tear fluid of patients with ocular graft-versus-host disease after allogeneic stem cell transplantation. Mol Vis. 2012;18:797.
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