The past few decades have seen the emergence of domino reactions as a powerful tool for the multi-functionalization of alkynes for the rapid and smooth construction of complex molecular architectures. In this context, employing transition metal catalysis, vicinal/geminal cascade functionalization of alkynes involving C-C and C-O bond formation reaction has been a preferred strategy for the synthesis of oxygenated motifs. Despite this significant progress, reviews documenting such strategies are either metal/functional group-centric or target-oriented, thus hampering further developments. In this review, different conceptual approaches based on C-C and C-O bond-forming events of alkynes like carboxygenation (C-C and C=O bond formation), carboalkoxylation (C-C and C-OR bond formation), and carboacetoxylation (C-C and C-OAc bond formations) will be discussed and examples from the literature will be presented from the last two decades. Further, the reader will get a detailed insight into the mechanism of the different transformations.

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