MicroRNA-223-3p levels in serum-derived extracellular vesicles predict regression of M2BPGi-based liver fibrosis after hepatitis C virus eradication by direct-acting antiviral agents

Takehara T, Sakamoto N, Nishiguchi S, et al. Efficacy and safety of sofosbuvir-velpatasvir with or without ribavirin in HCV-infected Japanese patients with decompensated cirrhosis: an open-label phase 3 trial. J Gastroenterol. 2019;54:87–95.

Article  CAS  PubMed  Google Scholar 

Suda G, Ogawa K, Morikawa K, et al. Treatment of hepatitis C in special populations. J Gastroenterol. 2018;53:591–605.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Carmona I, Cordero P, Ampuero J, et al. Role of assessing liver fibrosis in management of chronic hepatitis C virus infection. Clin Microbiol Infect. 2016;22:839–45.

Article  CAS  PubMed  Google Scholar 

Tahata Y, Hikita H, Mochida S, et al. Liver-related events after direct-acting antiviral therapy in patients with hepatitis C virus-associated cirrhosis. J Gastroenterol. 2022;57:120–32.

Article  CAS  PubMed  Google Scholar 

Tahata Y, Hikita H, Mochida S, et al. Posttreatment liver function, but not baseline liver function stratifies patient survival after direct-acting antiviral treatment in decompensated cirrhosis with hepatitis C virus. J Gastroenterol. 2023. https://doi.org/10.1007/s00535-023-02039-x.

Article  PubMed  PubMed Central  Google Scholar 

El-Sherif O, Jiang ZG, Tapper EB, et al. Baseline factors associated with improvements in decompensated cirrhosis after direct-acting antiviral therapy for hepatitis C virus infection. Gastroenterology. 2018;154:2111-21.e8.

Article  CAS  PubMed  Google Scholar 

Seko Y, Moriguchi M, Hara T, et al. Presence of varices in patients after hepatitis C virus eradication predicts deterioration in the FIB-4 index. Hepatol Res. 2019;49:473–8.

Article  CAS  PubMed  Google Scholar 

Mauro E, Crespo G, Montironi C, et al. Portal pressure and liver stiffness measurements in the prediction of fibrosis regression after sustained virological response in recurrent hepatitis C. Hepatology. 2018;67:1683–94.

Article  PubMed  Google Scholar 

Suzuki T, Matsuura K, Nagura Y, et al. Serum angiopoietin-2 levels predict regression of Mac-2 binding protein glycosylation isomer-based liver fibrosis after hepatitis C virus eradication by direct-acting antiviral agents. Hepatol Res. 2022;52:919–27.

Article  CAS  PubMed  Google Scholar 

Nagura Y, Suzuki T, Matsuura K, et al. Serum inducible protein 10 kDa/C-X-C motif chemokine 10 levels predict regression of M2BPGi-based liver fibrosis after hepatitis C virus eradication by direct-acting antiviral agents. Hepatol Res. 2024;54:32–42.

Article  CAS  PubMed  Google Scholar 

Gu J, Xu H, Chen Y, et al. MiR-223 as a regulator and therapeutic target in liver diseases. Front Immunol. 2022;13: 860661.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hildonen S, Skarpen E, Halvorsen TG, et al. Isolation and mass spectrometry analysis of urinary extraexosomal proteins. Sci Rep. 2016;6:36331.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xu H, Liao C, Zuo P, et al. Magnetic-based microfluidic device for on-chip isolation and detection of tumor-derived exosomes. Anal Chem. 2018;90:13451–8.

Article  CAS  PubMed  Google Scholar 

Zhang Y, Kim MS, Jia B, et al. Hypothalamic stem cells control ageing speed partly through exosomal miRNAs. Nature. 2017;548:52–7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tadokoro T, Morishita A, Masaki T. Diagnosis and therapeutic management of liver fibrosis by microRNA. Int J Mol Sci. 2021;22:8139.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Matsuura K, De Giorgi V, Schechterly C, et al. Circulating let-7 levels in plasma and extracellular vesicles correlate with hepatic fibrosis progression in chronic hepatitis C. Hepatology. 2016;64:732–45.

Article  CAS  PubMed  Google Scholar 

Matsuura K, Aizawa N, Enomoto H, et al. Circulating let-7 levels in serum correlate with the severity of hepatic fibrosis in chronic hepatitis C. Open Forum Infect Dis. 2018;5:ofy268.

Article  PubMed  PubMed Central  Google Scholar 

Babuta M, Szabo G. Extracellular vesicles in inflammation: focus on the microRNA cargo of EVs in modulation of liver diseases. J Leukoc Biol. 2022;111:75–92.

Article  CAS  PubMed  Google Scholar 

Yukawa H, Yamazaki S, Aoki K, et al. Co-continuous structural effect of size-controlled macro-porous glass membrane on extracellular vesicle collection for the analysis of miRNA. Sci Rep. 2021;11:8672.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sasaki R, Yamasaki K, Abiru S, et al. Serum Wisteria floribunda agglutinin-positive Mac-2 binding protein values predict the development of hepatocellular carcinoma among patients with chronic hepatitis c after sustained virological response. PLoS One. 2015;10: e0129053.

Article  PubMed  PubMed Central  Google Scholar 

Yamasaki K, Tateyama M, Abiru S, et al. Elevated serum levels of Wisteria floribunda agglutinin-positive human Mac-2 binding protein predict the development of hepatocellular carcinoma in hepatitis C patients. Hepatology. 2014;60:1563–70.

Article  CAS  PubMed  Google Scholar 

Xiao G, Yang J, Yan L. Comparison of diagnostic accuracy of aspartate aminotransferase to platelet ratio index and fibrosis-4 index for detecting liver fibrosis in adult patients with chronic hepatitis B virus infection: a systemic review and meta-analysis. Hepatology. 2015;61:292–302.

Article  PubMed  Google Scholar 

Johnson PJ, Berhane S, Kagebayashi C, et al. Assessment of liver function in patients with hepatocellular carcinoma: a new evidence-based approach-the ALBI grade. J Clin Oncol. 2015;33:550–8.

Article  PubMed  Google Scholar 

Ramsköld D, Luo S, Wang YC, et al. Full-length mRNA-Seq from single-cell levels of RNA and individual circulating tumor cells. Nat Biotechnol. 2012;30:777–82.

Article  PubMed  PubMed Central  Google Scholar 

Kanda Y. Investigation of the freely available easy-to-use software “EZR” for medical statistics. Bone Marrow Transplant. 2013;48:452–8.

Article  CAS  PubMed  Google Scholar 

Setiawan VW, Rosen HR. Stratification of residual risk of HCC following HCV clearance with direct-acting antivirals in patients with advanced fibrosis and cirrhosis. Hepatology. 2020;72:1897–9.

Article  PubMed  Google Scholar 

Lemoinne S, Thabut D, Housset C, et al. The emerging roles of microvesicles in liver diseases. Nat Rev Gastroenterol Hepatol. 2014;11:350–61.

Article  CAS  PubMed  Google Scholar 

Schwarzenbach H, Nishida N, Calin GA, et al. Clinical relevance of circulating cell-free microRNAs in cancer. Nat Rev Clin Oncol. 2014;11:145–56.

Article  CAS  PubMed  Google Scholar 

Valadi H, Ekström K, Bossios A, et al. Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat Cell Biol. 2007;9:654–9.

Article  CAS  PubMed  Google Scholar 

Arrese M, Eguchi A, Feldstein AE. Circulating microRNAs: emerging biomarkers of liver disease. Semin Liver Dis. 2015;35:43–54.

Article  CAS  PubMed  Google Scholar 

Kamerkar S, LeBleu VS, Sugimoto H, et al. Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer. Nature. 2017;546:498–503.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Madeo M, Colbert PL, Vermeer DW, et al. Cancer exosomes induce tumor innervation. Nat Commun. 2018;9:4284.

Article  PubMed  PubMed Central  Google Scholar 

Liu F, Vermesh O, Mani V, et al. The exosome total isolation chip. ACS Nano. 2017;11:10712–23.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Shi L, Kuhnell D, Borra VJ, et al. Rapid and label-free isolation of small extracellular vesicles from biofluids utilizing a novel insulator based dielectrophoretic device. Lab Chip. 2019;19:3726–34.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Luo X, An M, Cuneo KC, et al. High-performance chemical isotope labeling liquid chromatography mass spectrometry for exosome metabolomics. Anal Chem. 2018;90:8314–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yoshida M, Yukawa H, Hayashi K, et al. Clinical impact of bile-derived exosomal microRNAs as novel diagnostic and prognostic biomarkers for biliary tract cancers. Cancer Sci. 2023;114:295–305.

Article  CAS  PubMed 

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