Systemic immune markers and infection risk in preterm infants fed human milk fortified with bovine colostrum or conventional fortifier, a secondary analysis of the FortiColos trial

Stoll BJ, Hansen NI, Higgins RD, Fanaroff AA, Duara S, Goldberg R, et al. Very low birth weight preterm infants with early onset neonatal sepsis: the predominance of gram-negative infections continues in the national institute of child health and human development neonatal research network, 2002–2003. Pediatr Infect Dis J. 2005;24:635–9.

Article  PubMed  Google Scholar 

Tröger B, Göpel W, Faust K, Müller T, Jorch G, Felderhoff-Müser U, et al. Risk for late-onset blood-culture proven sepsis in very-low-birth weight infants born small for gestational age: a large multicenter study from the german neonatal network. Pediatr Infect Dis J. 2014;33:238–43.

Article  PubMed  Google Scholar 

McGuire W, Henderson G, Fowlie PW. Feeding the preterm infant. BMJ. 2004;329:1227–30.

Article  PubMed  PubMed Central  Google Scholar 

Bührer C, Fischer HS, Wellmann S. Nutritional interventions to reduce rates of infection, necrotizing enterocolitis and mortality in very preterm infants. Pediatr Res. 2020;87:371–7.

Article  PubMed  Google Scholar 

el Manouni el Hassani S, Berkhout DJC, Niemarkt HJ, Mann S, deBoode WP, Cossey V, et al. Risk factors for late-onset sepsis in preterm infants: a multicenter case-control study. Neonatology. 2019. https://doi.org/10.1159/000497781.

Article  PubMed  Google Scholar 

Victora CG, Bahl R, Barros AJD, França GVA, Horton S, Krasevec J, et al. Breastfeeding in the 21st century: epidemiology, mechanisms, and lifelong effect. Lancet. 2016;387:475–90.

Article  PubMed  Google Scholar 

Andreas NJ, Kampmann B, Mehring L-D. Human breast milk: a review on its composition and bioactivity. Early Hum Dev. 2015;91:629–35.

Article  CAS  PubMed  Google Scholar 

Allen JC, Keller RP, Archer P, Neville MC. Studies in human lactation: milk composition and daily secretion rates of macronutrients in the first year of lactation. Am J Clin Nutr. 1991;54:69–80.

Article  CAS  PubMed  Google Scholar 

Lapillonne A, Bronsky J, Campoy C, Embleton N, Fewtrell M, Fidler Mis N, et al. Feeding the late and moderately preterm infant: a position paper of the european society for paediatric gastroenterology, hepatology and nutrition committee on nutrition. J Pediatr Gastroenterol Nutr. 2019;69:259–70.

Article  PubMed  Google Scholar 

Vandenplas Y, Ksiażyk J, Luna MS, Migacheva N, Picaud JC, Ramenghi LA, et al. Partial hydrolyzed protein as a protein source for infant feeding: do or don’t? Nutrients. 2022. https://doi.org/10.3390/nu14091720.

Article  PubMed  PubMed Central  Google Scholar 

Rathe M, Müller K, Sangild PT, Husby S. Clinical applications of bovine colostrum therapy: a systematic review. Nutr Rev. 2014;72:237–54.

Article  PubMed  Google Scholar 

Juhl SM, Ye X, Zhou P, Li Y, Iyore EO, Zhang L, et al. Bovine colostrum for preterm infants in the first days of life: a randomized controlled pilot trial. J Pediatr Gastroenterol Nutr. 2018;66:471–8.

Article  PubMed  Google Scholar 

Zhang L, Boeren S, Hageman JA, Van Hooijdonk T, Vervoort J, Hettinga K. Bovine milk proteome in the first 9 days: protein interactions in maturation of the immune and digestive system of the newborn. PLoS ONE. 2015;10: e0116710.

Article  PubMed  PubMed Central  Google Scholar 

Zhang L, van Dijk ADJ, Hettinga K. An interactomics overview of the human and bovine milk proteome over lactation. Proteome Sci. 2017;15:1–14.

Article  PubMed  PubMed Central  Google Scholar 

Nissen A, Bendixen E, Ingvartsen KL, Røntved CM. In-depth analysis of low abundant proteins in bovine colostrum using different fractionation techniques. Proteomics. 2012;12:2866–78.

Article  CAS  PubMed  Google Scholar 

Pakkanen R, Aalto J. Growth factors and antimicrobial factors of bovine colostrum. Int Dairy J. 1997;7:285–97.

Article  CAS  Google Scholar 

Nguyen DN, Currie AJ, Ren S, Bering SB, Sangild PT. Heat treatment and irradiation reduce anti-bacterial and immune-modulatory properties of bovine colostrum. J Funct Foods. 2019;57:182–9.

Article  CAS  Google Scholar 

Chatterton DEW, Nguyen DN, Bering SB, Sangild PT. Anti-inflammatory mechanisms of bioactive milk proteins in the intestine of newborns. Int J Biochem Cell Biol. 2013;45:1730–47.

Article  CAS  PubMed  Google Scholar 

Ren S, Hui Y, Goericke-Pesch S, Pankratova S, Kot W, Pan X, et al. Gut and immune effects of bioactive milk factors in preterm pigs exposed to prenatal inflammation. Am J Physiol Gastrointest Liver Physiol. 2019;317:G67-77.

Article  CAS  PubMed  Google Scholar 

Bæk O, Brunse A, Nguyen DN, Moodley A, Thymann T, Sangild PT. Diet modulates the high sensitivity to systemic infection in newborn preterm pigs. Front Immunol. 2020. https://doi.org/10.3389/fimmu.2020.01019.

Article  PubMed  PubMed Central  Google Scholar 

Li Y, Pan X, Nguyen DN, Ren S, Moodley A, Sangild PT. Bovine colostrum before or after formula feeding improves systemic immune protection and gut function in newborn preterm pigs. Front Immunol. 2020;10:3062.

Article  PubMed  PubMed Central  Google Scholar 

Sun J, Li Y, Pan X, Nguyen DN, Brunse A, Bojesen AM, et al. Human milk fortification with bovine colostrum is superior to formula-based fortifiers to prevent gut dysfunction, necrotizing enterocolitis, and systemic infection in preterm pigs. J Parenter Enter Nutr. 2019;43:252–62.

Article  CAS  Google Scholar 

Sun J, Li Y, Nguyen DN, Mortensen MS, van den Akker CHP, Skeath T, et al. Nutrient fortification of human donor milk affects intestinal function and protein metabolism in preterm pigs. J Nutr. 2018. https://doi.org/10.1093/jn/nxx033.

Article  PubMed  Google Scholar 

Yan X, Pan X, Ding L, Dai Y, Chen J, Yang Y, et al. Bovine colostrum to supplement the first feeding of very preterm infants: the precolos randomized controlled trial. Clin Nutr. 2023;42:1408–17.

Article  CAS  PubMed  Google Scholar 

Ismail RIH, Awad HA, Imam SS, Gad GI, Aboushady NM, Abdou RM, et al. Gut priming with bovine colostrum and T regulatory cells in preterm neonates: a randomized controlled trial. Pediatr Res. 2021. https://doi.org/10.1038/s41390-020-01344-y.

Article  PubMed  Google Scholar 

Ahnfeldt AM, Aunsholt L, Hansen BM, Hoest B, Jóhannsdóttir V, Kappel SS, et al. Bovine colostrum as a fortifier to human milk in very preterm infants — a randomized controlled trial (FortiColos). Clin Nutr. 2023;42:773–83.

Article  CAS  PubMed  Google Scholar 

Kappel SS, Sangild PT, Ahnfeldt AM, Jóhannsdóttir V, Soernsen LJ, Bak LB, et al. A randomized, controlled study to investigate how bovine colostrum fortification of human milk affects bowel habits in preterm infants (Forticolos study). Nutrients. 2022;14:4756.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ahnfeldt AM, Hyldig N, Li Y, Kappel SS, Aunsholdt L, Sangild PT, et al. FortiColos — a multicentre study using bovine colostrum as a fortifier to human milk in very preterm infants: study protocol for a randomised controlled pilot trial. Trials. 2019;20:1–9.

Article  CAS  Google Scholar 

Agostoni C, Buonocore G, Carnielli V, de Curtis M, Darmaun D, Decsi T, et al. Enteral nutrient supply for preterm infants: commentary from the european society of paediatric gastroenterology, hepatology and nutrition committee on nutrition. J Pediatr Gastroenterol Nutr. 2010;50:85–91.

Article  CAS  PubMed  Google Scholar 

Niklasson A, Albertsson-Wikland K. Continuous growth reference from 24th week of gestation to 24 months by gender. BMC Pediatr. 2008. https://doi.org/10.1186/1471-2431-8-8.

Article  PubMed  PubMed Central  Google Scholar 

Prentice RL, Williams BJ, Peterson AV. On the regression analysis of multivariate failure time data. Biometrika. 1981. https://doi.org/10.1093/biomet/68.2.373.

Article  Google Scholar 

Firth D. Bias reduction of maximum likelihood estimates. Biometrika. 1993;80:27–38.

Article  Google Scholar 

Ling EM, Smith T, Nguyen XD, Pridgeon C, Dallman M, Arbery J, et al. Relation of CD4+CD25+ regulatory T-cell suppression of allergen-driven T-cell activation to atopic status and expression of allergic disease. Lancet. 2004;363:608–15.

Article  CAS  PubMed  Google Scholar 

Rubtsov YP, Rasmussen JP, Chi EY, Fontenot J, Castelli L, Ye X, et al. Regulatory T cell-derived interleukin-10 limits inflammation at environmental interfaces. Immunity. 2008;28:546–58.

Article  CAS  PubMed  Google Scholar 

Wong EB, Mallet JF, Duarte J, Matar C, Ritz BW. Bovine colostrum enhances natural killer cell activity and immune response in a mouse model of influenza infection and mediates intestinal immunity through toll-like receptors 2 and 4. Nutr Res. 2014;34:318–25.

Article  CAS  PubMed  Google Scholar 

Xu ML, Kim HJ, Wi GR, Kim HJ. The effect of dietary bovine colostrum on respiratory syncytial virus infection and immune responses following the infection in the mouse. J Microbiol. 2015;53:661–6.

Article  CAS  PubMed  Google Scholar 

Li J, Xu YW, Jiang JJ, Song QK. Bovine colostrum and product intervention associated with relief of childhood infectious diarrhea. Sci Rep. 2019. https://doi.org/10.1038/s41598-019-39644-x.

Article  PubMed 

Comments (0)

No login
gif