Virgin HWt, Latreille P, Wamsley P, Hallsworth K, Weck KE, Dal Canto AJ, et al. Complete sequence and genomic analysis of murine gammaherpesvirus 68. J Virol. 1997;71(8):5894–904.

Blaskovic D, Stancekova M, Svobodova J, Mistrikova J. Isolation of five strains of herpesviruses from two species of free living small rodents. Acta Virol. 1980;24(6):468.

CAS  PubMed  Google Scholar 

Barton E, Mandal P, Speck SH. Pathogenesis and host control of gammaherpesviruses: Lessons from the mouse. Annu Rev Immunol. 2011;29:351–97.

Article  CAS  PubMed  Google Scholar 

Wang Y, Tibbetts SA, Krug LT. Conquering the host: determinants of pathogenesis learned from murine gammaherpesvirus 68. Ann Rev Virol. 2021;8(1):349–71.

Article  CAS  Google Scholar 

Gaspar M, May JS, Sukla S, Frederico B, Gill MB, Smith CM, et al. Murid herpesvirus-4 exploits dendritic cells to infect B cells. PLoS Pathog. 2011;7(11):e1002346.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Flano E, Kim IJ, Woodland DL, Blackman MA. Gamma-herpesvirus latency is preferentially maintained in splenic germinal center and memory B cells. J Exp Med. 2002;196(10):1363–72.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Roughan JE, Thorley-Lawson DA. The intersection of Epstein-Barr virus with the germinal center. J Virol. 2009;83(8):3968–76.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Stebegg M, Kumar SD, Silva-Cayetano A, Fonseca VR, Linterman MA, Graca L. Regulation of the germinal center response. Front Immunol 2018;9:2469.

Willer DO, Speck SH. Establishment and maintenance of long-term murine gammaherpesvirus 68 latency in B cells in the absence of CD40. J Virol. 2005;79(5):2891.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Babcock GJ, Decker LL, Freeman RB, Thorley-Lawson DA. Epstein-barr virus-infected resting memory B cells, not proliferating lymphoblasts, accumulate in the peripheral blood of immunosuppressed patients. J Exp Med. 1999;190(4):567–76.

Article  CAS  PubMed  PubMed Central  Google Scholar 

•Bussey KA, Murthy S, Reimer E, Chan B, Hatesuer B, Schughart K, et al. Endosomal toll-like receptors 7 and 9 cooperate in detection of murine gammaherpesvirus 68 infection. J Virol. 2019;93(3):e01173–18. The study demonstrates that TLR7 and TLR9 exhibit cooperativity while detecting and controlling MHV68 latency.

Pasare C, Medzhitov R. Toll-like receptors: Linking innate and adaptive immunity. Microbes Infect. 2004;6(15):1382–7.

Article  CAS  PubMed  Google Scholar 

Sartorius R, Trovato M, Manco R, D’Apice L, De Berardinis P. Exploiting viral sensing mediated by Toll-like receptors to design innovative vaccines. NPJ Vaccines. 2021;6(1):127.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Duan T, Du Y, Xing C, Wang HY, Wang RF. Toll-like receptor signaling and its role in cell-mediated immunity. Front Immunol. 2022;13:812774.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gargano LM, Moser JM, Speck SH. Role for MyD88 signaling in murine gammaherpesvirus 68 latency. J Virol. 2008;82(8):3853–63.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu T, Zhang L, Joo D, Sun S-C. NF-κB signaling in inflammation. Signal Transduct Target Ther. 2017;2(1):17023.

Article  PubMed  PubMed Central  Google Scholar 

Brown HJ, Song MJ, Deng HY, Wu TT, Cheng GH, Sun R. NF-kappa B inhibits gammaherpesvirus lytic replication. J Virol. 2003;77(15):8532–40.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Krug LT, Moser JM, Dickerson SM, Speck SH. Inhibition of NF-kB activation in vivo impairs establishment of gammaherpesvirus latency. PLoS Pathog. 2007;3:97–118.

Article  CAS  Google Scholar 

Krug LT, Collins CM, Gargano LM, Speck SH. NF-kappaB p50 plays distinct roles in the establishment and control of murine gammaherpesvirus 68 latency. J Virol. 2009;83(10):4732–48.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rodrigues L, Filipe J, Seldon MP, Fonseca L, Anrather J, Soares MP, et al. Termination of NF-kappaB activity through a gammaherpesvirus protein that assembles an EC5S ubiquitin-ligase. EMBO J. 2009;28(9):1283–95.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Frederico B, May JS, Efstathiou S, Stevenson PG. BAFF receptor deficiency limits gammaherpesvirus infection. J Virol. 2014;88(8):3965–75.

Article  PubMed  PubMed Central  Google Scholar 

••Cieniewicz B, Kirillov V, Daher I, Li X, Oldenburg DG, Dong Q, et al. IKKα-Mediated noncanonical NF-κB signaling is required to support murine gammaherpesvirus 68 latency in vivo. J Virol. 2022;96(10):e0002722. The study supports the role of non-canonical NF-kB signaling in establishment of MHV68 latency.

Stetson DB, Medzhitov R. Type I interferons in host defense. Immunity. 2006;25(3):373–81.

Article  CAS  PubMed  Google Scholar 

Shrestha B, Wang T, Samuel MA, Whitby K, Craft J, Fikrig E, et al. Gamma interferon plays a crucial early antiviral role in protection against West Nile virus infection. J Virol. 2006;80(11):5338–48.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bhat P, Leggatt G, Waterhouse N, Frazer IH. Interferon-gamma derived from cytotoxic lymphocytes directly enhances their motility and cytotoxicity. Cell Death Dis. 2017;8(6):e2836.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wack A, Terczynska-Dyla E, Hartmann R. Guarding the frontiers: The biology of type III interferons. Nat Immunol. 2015;16(8):802–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Barton ES, Lutzke ML, Rochford R, Virgin HWt. Alpha/beta interferons regulate murine gammaherpesvirus latent gene expression and reactivation from latency. J Virol. 2005;79(22):14149–60.

Mandal P, Krueger BE, Oldenburg D, Andry KA, Beard RS, White DW, et al. A gammaherpesvirus cooperates with interferon-alpha/beta-induced IRF2 to halt viral replication, control reactivation, and minimize host lethality. PLoS Pathog. 2011;7(11):e1002371.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Schwerk J, Kemper L, Bussey KA, Lienenklaus S, Weiss S, Čičin-Šain L, et al. Type I interferon signaling controls gammaherpesvirus latency in vivo. Pathogens (Basel, Switzerland). 2022;11(12):1554.

Tibbetts SA, van Dyk LF, Speck SH, Virgin HWt. Immune control of the number and reactivation phenotype of cells latently infected with a gammaherpesvirus. J Virol. 2002;76(14):7125–32.

Steed AL, Barton ES, Tibbetts SA, Popkin DL, Lutzke ML, Rochford R, et al. Gamma interferon blocks gammaherpesvirus reactivation from latency. J Virol. 2006;80(1):192–200.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Honda K, Takaoka A, Taniguchi T. Type I interferon [corrected] gene induction by the interferon regulatory factor family of transcription factors. Immunity. 2006;25(3):349–60.

Article  CAS  PubMed  Google Scholar 

Schoggins JW, Wilson SJ, Panis M, Murphy MY, Jones CT, Bieniasz P, et al. A diverse range of gene products are effectors of the type I interferon antiviral response. Nature. 2011;472(7344):481–5.

Article  CAS  PubMed  PubMed Central  ADS  Google Scholar 

Goodwin MM, Canny S, Steed A, Virgin HW. Murine gammaherpesvirus 68 has evolved gamma interferon and stat1-repressible promoters for the lytic switch gene 50. J Virol. 2010;84(7):3711–7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wood BM, Mboko WP, Mounce BC, Tarakanova VL. Mouse gammaherpesvirus-68 infection acts as a rheostat to set the level of type I interferon signaling in primary macrophages. Virology. 2013;443(1):123–33.

Article  CAS  PubMed  Google Scholar 

Lenschow DJ, Lai C, Frias-Staheli N, Giannakopoulos NV, Lutz A, Wolff T, et al. IFN-stimulated gene 15 functions as a critical antiviral molecule against influenza, herpes, and Sindbis viruses. Proc Natl Acad Sci USA. 2007;104(4):1371–6.

Article  CAS  PubMed  PubMed Central  ADS  Google Scholar 

Aricò E, Monque DM, D’Agostino G, Moschella F, Venditti M, Kalinke U, et al. MHV-68 producing mIFNα1 is severely attenuated in vivo and effectively protects mice against challenge with wt MHV-68. Vaccine. 2011;29(23):3935–44.

Article  PubMed  Google Scholar 

Sylvester PA, Jondle CN, Stoltz KP, Lanham J, Dittel BN, Tarakanova VL. Conserved gammaherpesvirus protein kinase counters the antiviral effects of myeloid cell-specific STAT1 expression to promote the establishment of splenic B cell latency. J Virol. 2021;95(17):e0085921.

Article  CAS  PubMed  Google Scholar 

•Sylvester PA, Jondle CN, Schmalzriedt DL, Dittel BN, Tarakanova VL. T cell-specific STAT1 expression promotes lytic replication and supports the establishment of gammaherpesvirus latent reservoir in splenic B cells. mBio. 2022;13(4):e0210722. The study reveals that T-cell specific STAT1 activity promotes acute and persistent MHV68 replication in the lungs and also establishes latent viral reservoir in B cells.

Mboko WP, Olteanu H, Ray A, Xin G, Darrah EJ, Kumar SN, et al. Tumor suppressor interferon-regulatory factor 1 counteracts the germinal center reaction driven by a cancer-associated gammaherpesvirus. J Virol. 2016;90(6):2818–29.

Article  CAS  PubMed Central  Google Scholar 

•Jondle CN, Johnson KE, Uitenbroek AA, Sylvester PA, Nguyen C,