Introduction: Trazodone is an antidepressant agent approved for treating major depressive disorders and is also prescribed for
insomnia due to its sedative effect. In a few cases, trazodone was associated with parkinsonism. Herein, we describe a case of
parkinsonism after a brief exposure to a moderate dose of trazodone.

Objective: To describe a case of a patient with trazodone-induced parkinsonism in which the diagnosis was suspected after the
exclusion of other common and serious causes.

Methods: A case report of trazodone-induced parkinsonism.

Clinical Case: A 58-year-old male with sleeping problems was prescribed trazodone 50 mg daily at bedtime. The subject doubled
the dosage without medical advice a week later. After 14 days of trazodone treatment, he started to experience difficulty in
moving his upper limbs and recurrent falling. Neuroimaging, electrodiagnostic studies, and laboratory exams were unremarkable.
Trazodone was discontinued, and the patient fully recovered. Noteworthy, the patient developed a recurrence of the motor
symptoms with trazodone-rechallenge.

Conclusion: Our case showed reversibly induced parkinsonism after a short intake of a moderate dose of trazodone which was
prescribed for insomnia. The patient had a complete recovery after trazodone withdrawal. Noteworthy, the symptoms recurred
upon trazodone-rechallenge.

Keywords: Trazodone; triazolopyridine; parkinsonism; movement disorder; drug-induced.