American Psychiatric Association. Substance-related and addictive disorders. 5th ed. Arlington: American Psychiatric Association; 2013.

Google Scholar 

Key substance use and mental health indicators in the United States: Results from the 2021 National Survey on Drug Use and Health (HHS Publication No. PEP22-07-01-005, NSDUH Series H-57). Center for Behavioral Health Statistics and Quality, Substance Abuse and Mental Health Services Administration. Available from: https://www.samhsa.gov/data/report/2021-nsduh-annual-national-report. (Accessed 19 Dec 2023).

General OotS. Addiction and substance misuse reports and publications. 2023. Available from: https://www.hhs.gov/surgeongeneral/reports-and-publications/addiction-and-substance-misuse/index.html#:~:text=The%20annual%20economic%20impact%20of,billion%20for%20illicit%20drug%20use. (Accessed 19 Dec 2023).

Drug overdose death rates. 2023. Available from: https://drugabusestatistics.org/drug-overdose-deaths/. (Accessed 19 Dec 2023).

Overdose death and the involvement of ilicit drugs: urgent need for overdose prevention strategies. 2023. Available from: https://www.cdc.gov/drugoverdose/featured-topics/VS-overdose-deaths-illicit-drugs.html. (Accessed 19 Dec 2023).

O’Donnell J, Matt Gladden R, Mattson CL, Hunter CT, Davis NL. Vital signs: characteristics of drug overdose deaths involving opioids and stimulants: 24 states and the District of Columbia, January–June 2019. MMWR Morb Mortal Wkly Rep. 2020;35(69):1189–97.

Article  Google Scholar 

Philipone EM, Peters SM. Ulcerative and inflammatory lesions of the oral mucosa. Oral Maxillofac Surg Clin North Am. 2023;35(2):219–26.

Article  PubMed  Google Scholar 

Proulx V, Tousignant B. Drugs of abuse and ocular effects. Clin Exp Optom. 2021;104(5):567–78.

Article  PubMed  Google Scholar 

Hennings C, Miller J. Illicit drugs: what dermatologists need to know. J Am Acad Dermatol. 2013;69(1):135–42.

Article  PubMed  Google Scholar 

Albattal RRH, Ye-Li Y, Albloushi FAJ, Albarmaqi RA, Malik A, Wasay A. Dermatologic manifestations of substance abuse. Int J Sci Invent Today. 2021;10(2):131–52.

Google Scholar 

NIDA. How can inhalant abuse be recognized? 2022. Available from: https://nida.nih.gov/publications/research-reports/inhalants/how-can-inhalant-abuse-be-recognized. (Accessed 19 Dec 2023).

Moreno-Artero E, Querol-Cisneros E, Rodríguez-Garijo N, Tomás-Velázquez A, Antoñanzas J, Secundino F, et al. Mucocutaneous manifestations of cocaine abuse: a review. J Eur Acad Dermatol Venereol. 2018;32(9):1420–6.

Article  CAS  PubMed  Google Scholar 

Cheng GL, Zeng H, Leung MK, Zhang HJ, Lau BW, Liu YP, et al. Heroin abuse accelerates biological aging: a novel insight from telomerase and brain imaging interaction. Transl Psychiatry. 2013;3(5): e260.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Reece AS. Hair graying in substance addiction. Arch Dermatol. 2007;143(1):115–26.

Article  Google Scholar 

George S, Moselhy H. Cocaine-induced trichotillomania. Addiction. 2005;100(2):255–6.

Article  PubMed  Google Scholar 

Hamalian G, Citrome L. Stimulant-induced trichotillomania. Subst Abus. 2010;31(1):68–70.

Article  PubMed  Google Scholar 

Park KK, Brodell RT, Helms SE. Angular cheilitis, part 2: nutritional, systemic, and drug-related causes and treatment. Cutis. 2011;88(1):27–32.

PubMed  Google Scholar 

Brewer JD, Meves A, Bostwick JM, Hamacher KL, Pittelkow MR. Cocaine abuse: dermatologic manifestations and therapeutic approaches. J Am Acad Dermatol. 2008;59(3):483–7.

Article  PubMed  Google Scholar 

Weidman AI, Fellner MJ. Cutaneous manifestations of heroin and other addictive drugs. Study and analysis. N Y State J Med. 1971;71(22):2643–6.

CAS  PubMed  Google Scholar 

Lipman ZM, Yosipovitch G. Substance use disorders and chronic itch. J Am Acad Dermatol. 2021;84(1):148–55.

Article  CAS  PubMed  Google Scholar 

Marshall CL, Williams V, Ellis C, Taylor RE, Bewley AP. Delusional infestation may be caused by recreational drug usage in some patients, but they may not disclose their habit. Clin Exp Dermatol. 2017;42(1):41–5.

Article  CAS  PubMed  Google Scholar 

Hadzic S, Dedic A, Gojkov-Vukelic M, Mehic-Basara N, Hukic M, Babic M, et al. The effect of psychoactive substances (drugs) on the presence and frequency of oral Candida species and Candida dubliniensis. Mater Sociomed. 2013;25(4):223–5.

Article  PubMed  PubMed Central  Google Scholar 

Al-Bush MM. An oral cavity profile in illicit—Drug abusers? J Indian Soc Periodontol. 2019;23(6):517–24.

Article  PubMed  PubMed Central  Google Scholar 

Antoniazzi RP, Sari AR, Casarin M, Moraes CMB, Feldens CA. Association between crack cocaine use and reduced salivary flow. Braz Oral Res. 2017;5(31): e42.

Google Scholar 

Cossa F, Piastra A, Sarrion-Pérez MG, Bagán L. Oral manifestations in drug users: a review. J Clin Exp Dent. 2020;12(2):e193-200.

Article  PubMed  PubMed Central  Google Scholar 

Quaranta A, D’Isidoro O, Piattelli A, Hui WL, Perrotti V. Illegal drugs and periodontal conditions. Periodontol 2000. 2022;90(1):62–87.

Article  PubMed  PubMed Central  Google Scholar 

Poowanawittayakom N, Dutta A, Stock S, Touray S, Ellison RT 3rd, Levitz SM. Reemergence of intravenous drug use as risk factor for candidemia, Massachusetts, USA. Emerg Infect Dis. 2018;24(4):631–7.

Article  PubMed  PubMed Central  Google Scholar 

Del Giudice P. Cutaneous complications of intravenous drug abuse. Br J Dermatol. 2004;150(1):1–10.

Article  PubMed  Google Scholar 

Cole C, Jones L, McVeigh J, Kicman A, Syed Q, Bellis M. Adulterants in illicit drugs: a review of empirical evidence. Drug Test Anal. 2011;3(2):89–96.

Article  CAS  PubMed  Google Scholar 

Midthun KM, Nelson LS, Logan BK. Levamisole: a toxic adulterant in illicit drug preparations: a review. Ther Drug Monit. 2021;43(2):221–8.

Article  CAS  PubMed  Google Scholar 

Broséus J, Gentile N, Esseiva P. The cutting of cocaine and heroin: a critical review. Forensic Sci Int. 2016;262:73–83.

Article  PubMed  Google Scholar 

Ruiz-Colón K, Chavez-Arias C, Díaz-Alcalá JE, Martínez MA. Xylazine intoxication in humans and its importance as an emerging adulterant in abused drugs: a comprehensive review of the literature. Forensic Sci Int. 2014;240:1–8.

Article  PubMed  Google Scholar 

Kringsholm B, Christoffersen P. The nature and the occurrence of birefringent material in different organs in fatal drug addiction. Forensic Sci Int. 1987;34(1–2):53–62.

Article  CAS  PubMed  Google Scholar 

Hahn HH, Schweid AI, Beaty HN. Complications of injecting dissolved methylphenidate tablets. Arch Intern Med. 1969;123(6):656–9.

Article  CAS  PubMed  Google Scholar 

Roux P, Carrieri MP, Keijzer L, Dasgupta N. Reducing harm from injecting pharmaceutical tablet or capsule material by injecting drug users. Drug Alcohol Rev. 2011;30(3):287–90.

Article  PubMed  Google Scholar 

Xie Y, Pope BA, Hunter AJ. Cotton fever: does the patient know best? J Gen Intern Med. 2016;31(4):442–4.

Article  PubMed  Google Scholar 

Geedipally H, Karki S, Shirke S, Bhimani R. Just a bad case of cotton fever: a case report and literature review. Cureus. 2022;14(8): e28352.

PubMed  PubMed Central  Google Scholar 

Mezaache S, Briand-Madrid L, Laporte V, Mora M, Moudachirou K, Rojas Castro D, et al. Correlates of self-reported cotton fever experience among people who inject opioids. Subst Use Misuse. 2020;55(6):1021–7.

Article  PubMed  Google Scholar 

Marks LR, Nolan NS, Liang SY, Durkin MJ, Weimer MB. Infectious complications of injection drug use. Med Clin North Am. 2022;106(1):187–200.

Article  PubMed  Google Scholar 

Hotton A, Mackesy-Amiti ME, Boodram B. Trends in homelessness and injection practices among young urban and suburban people who inject drugs: 1997–2017. Drug Alcohol Depend. 2021;1(225): 108797.

Article  Google Scholar 

Dahlman D, Berge J, Björkman P, Nilsson AC, Håkansson A. Both localized and systemic bacterial infections are predicted by injection drug use: a prospective follow-up study in Swedish criminal justice clients. PLoS One. 2018;13(5): e0196944.

Article  PubMed  PubMed Central  Google Scholar 

Mathers BM, Degenhardt L, Bucello C, Lemon J, Wiessing L, Hickman M. Mortality among people who inject drugs: a systematic review and meta-analysis. Bull World Health Organ. 2013;91(2):102–23.

Article  PubMed  PubMed Central  Google Scholar 

Sanchez DP, Tookes H, Pastar I, Lev-Tov H. Wounds and skin and soft tissue infections in people who inject drugs and the utility of syringe service programs in their management. Adv Wound Care (New Rochelle). 2021;10(10):571–82.

Article  PubMed  PubMed Central  Google Scholar 

Binswanger IA, Takahashi TA, Bradley K, Dellit TH, Benton KL, Merrill JO. Drug users seeking emergency care for soft tissue infection at high risk for subsequent hospitalization and death. J Stud Alcohol Drugs. 2008;69(6):924–32.

Article  PubMed  PubMed Central  Google Scholar 

Larney S, Peacock A, Mathers BM, Hickman M, Degenhardt L. A systematic review of injecting-related injury and disease among people who inject drugs. D