Advances in Pharmacology and Pharmacy Vol. 12(1), pp. 34 - 43
DOI: 10.13189/app.2024.120104
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Kanwal Asif 1,*, Humaira M Khan 2, Mahreen Siddique 1, Tanveer Ahmad Khan 3, Farah Syed 2, Humayun Riaz 1, Syed Atif Raza 4, Abdul Raheem Malik 1, Waqas Ahmad 1
1 Rashid Latif College of Pharmacy, Rashid Latif Medical Complex, Pakistan
2 Institute of Pharmacy, Faculty of Pharmaceutical and Allied Health Sciences, Lahore College for Women University, Pakistan
3 Drugs Control and Traditional Medicines Division, National Institute of Health, Pakistan
4 University College of Pharmacy, University of the Punjab, Pakistan

ABSTRACT

Stroke is the foremost cause of demise and disability globally. Nevertheless, treatment choices are still inadequate, despite decades of research. The study aimed to assess the neuroprotective effect of Olea europaea (extra virgin olive oil) (EVOE) and Malus domestica (apple cider vinegar) (MD) in the albino rat model of stroke. Their effect on motor and sensory functions (Locomotor asymmetry, forepaw dexterity, contralateral side injury, memory issues, and unilateral deficiency) was measured by cylinder test, pasta test, ladder rung walking test, Morris water maze test, and pole test, respectively. After 21 days of prophylactic dosing, the middle cerebral artery occlusion procedure induced the stroke. After the execution of the animals, 2,3,5 triphenyl tetrazolium chloride (TTC) was used to dye slices of the brain to measure the size of cerebral infarction. EVOE (0.75ml/kg/day) and MD (5ml/kg/day) alone have shown significant neuroprotective potential by improving the findings of the ladder rung walking test (P value

KEYWORDS
Ischemic Stroke, Albino Rats, Middle Cerebral Artery Occlusion, Olea Europaea, Malus Domestica, Neuroprotective Effect

Cite This Paper in IEEE or APA Citation Styles
(a). IEEE Format:
[1] Kanwal Asif , Humaira M Khan , Mahreen Siddique , Tanveer Ahmad Khan , Farah Syed , Humayun Riaz , Syed Atif Raza , Abdul Raheem Malik , Waqas Ahmad , "Neuroprotective Activity of Olea Europaea and Malus Domestica in Stroke Model of Albino Rat," Advances in Pharmacology and Pharmacy, Vol. 12, No. 1, pp. 34 - 43, 2024. DOI: 10.13189/app.2024.120104.

(b). APA Format:
Kanwal Asif , Humaira M Khan , Mahreen Siddique , Tanveer Ahmad Khan , Farah Syed , Humayun Riaz , Syed Atif Raza , Abdul Raheem Malik , Waqas Ahmad (2024). Neuroprotective Activity of Olea Europaea and Malus Domestica in Stroke Model of Albino Rat. Advances in Pharmacology and Pharmacy, 12(1), 34 - 43. DOI: 10.13189/app.2024.120104.