Advances in Pharmacology and Pharmacy Vol. 13(1), pp. 113 - 125
DOI: 10.13189/app.2025.130112
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Achla Vyas 1,*, Kapil Vyas 2
1 Department of Pharmacology, Shree Dhanvantary Pharmacy College, Kim, Surat, Gujarat 394110, India
2 Hikal LTD, Gujarat Industrial Development Corporation Panoli, Bharuch, Gujarat 394115, India

ABSTRACT

The Zebrafish model is more promising and less tedious than other models, so different biomedical research, toxicity studies, genetic research, carcinogenic studies, teratogenic studies, and other behavior studies like anxiolytic, anti-nociceptive, etc. performed on this model. The zebrafish models have demonstrated their efficacy by developing into very effective human disease models, and their use has expanded to encompass several study domains aimed at comprehending the fundamental processes behind the illnesses. Because there is 70% genetic similarity between the zebrafish and human genomes, zebrafish are being used as model animals to better understand the genetics and molecular basis of many diseases. As a result, new and intriguing information about these diseases is emerging, making zebrafish an extremely useful tool for future research. Due to more advantages and fewer complications, increasing numbers of experiments on zebrafish in India, it was required to have CCSEA or any other regulatory guidelines for handling zebrafish. In the year 2021, the CCSEA published guidelines for animal experimentation on fish, in which emphasis was given to the zebrafish model. The present review focuses on different Zebrafish used as research models in various pharmacological activities and CCSEA guidelines for experimentation and handling of zebrafish. Zebrafish are small, easily obtainable, easy to handle, most convenient for administering drug doses, and require a lesser dose overall. Another crucial feature of the transparent embryo of the Zebrafish is its ability to shed light on fish development, neurological development, and other mutation changes that have occurred during research. The majority of the new experimental techniques covered in this article will aid in understanding various approaches and the suitability of the fish model. It will also aid in understanding various factors to be considered when choosing the best model for a given study.

KEYWORDS
Zebrafish, Zebrafish Research Model, Regulatory Guidelines for Zebrafish, Pharmacological Research Model, Cancer Research, Genetic Research, Transparent Embryo

Cite This Paper in IEEE or APA Citation Styles
(a). IEEE Format:
[1] Achla Vyas , Kapil Vyas , "Review on Emerging Benefits of Zebrafish in Extent Future of Pharmacology in India," Advances in Pharmacology and Pharmacy, Vol. 13, No. 1, pp. 113 - 125, 2025. DOI: 10.13189/app.2025.130112.

(b). APA Format:
Achla Vyas , Kapil Vyas (2025). Review on Emerging Benefits of Zebrafish in Extent Future of Pharmacology in India. Advances in Pharmacology and Pharmacy, 13(1), 113 - 125. DOI: 10.13189/app.2025.130112.