Current knowledge about psychosis originates almost entirely from high-income countries while little data is derived from low- and middle-income countries (LMICs). This Research Topic collects five comprehensive original research studies delving into the complex landscape of psychosis spanning Southeast Europe, Asia, and Africa. Each paper contributes uniquely to our understanding of psychosis in LMICs, exploring various facets within this complex domain from negative symptoms, to psychopharmacological treatments, and traditional healing practices. These papers utilise diverse research methodologies, encompassing cross-sectional, longitudinal, quantitative, and qualitative studies.

Due to its heterogeneity, identifying distinct subgroups within patients with schizophrenia is important to shed light on its pathophysiology and provide tailored treatments. Uka et al. used latent profile analysis in a sample of 103 patients with schizophrenia from Kosovo to explore how patients’ profiles based on demographic and socio-economic variables impact on negative symptoms, health status, and the quality of life. Four distinctive profiles emerged and showed a profound influence on mobility in health, quality of life, and two facets of negative symptoms (i.e., motivation and pleasure domain). These findings could potentially inform person-centre approaches to enhance the well-being and quality of life for individuals suffering with schizophrenia.

The investigation into clozapine prescription in LMICs is pertinent for several reasons. Despite clozapine stands as a gold standard for treating treatment-resistant schizophrenia, offering notable clinical and economic advantages over alternative antipsychotics, is usually under-prescribed due to potentially severe adverse effects (i.e., agranulocytosis, neutropenia, and various cardiac and metabolic complications) and to inadequate knowledge about the drug, patient noncompliance, and resource limitations for blood monitoring and treatment protocols. Whilst this data is mainly derived from Western countries, clozapine usage in LMICs remains limited and inconsistently documented. In this study, Russo et al. unveils higher prescription rates in five Southeast European (SEE) countries compared to Western Europe. However, the dosages often fall below recommended therapeutic levels, implying potential off-label usage that warrants further exploration. This study offers valuable insights into psychosis treatment practices in LMICs in Southeast Europe.

Gao et al. directed their focus towards the association between negative symptom and social functioning in a large sample (n=202) of patients with schizophrenia from China. Specifically, this study looked at dimensions of negative symptoms (i.e., motivation, expression and emotion) whose specific contributions to social functioning remained unclear. The investigation revealed a noteworthy correlation between motivation and social functioning, spotlighting motivation as a potential therapeutic target crucial for enhancing patients’ social welfare. By understanding the intricate relationship between motivation and social functioning, clinicians and researchers can potentially devise tailored strategies to address this critical aspect of patient care, ultimately ameliorating the social outcomes for individuals grappling with schizophrenia in the Chinese context.

Employing a combination of individual interviews and focus groups involving individuals with psychosis, their caregivers, and service providers, Khan et al. found that a substantial portion of individuals suffering with psychosis engaged with both formal psychiatric avenues and traditional healing practices for care. Namely, five overarching themes emerged: perception of psychosis, seeking and receiving care experiences, evaluation and diagnostic approaches, service promotion, and the realities of living with psychosis. The findings underscored a dual reliance on traditional healing practices alongside conventional biomedical treatments. Therefore, it would be imperative to establish a dialogue between traditional and clinical healthcare systems. Moreover, the study shed light on a widespread lack of awareness among both formal and informal care providers regarding severe mental health conditions, and on the existence of multifaceted barriers hindering effective treatment (e.g., limited healthcare facilities and professionals, stigma, caregiver burdens, and the dissemination of misinformation by faith healers).

van der Zeijst et al. present a longitudinal study about the course of psychotic experiences among 48 apprentice THPs in rural South Africa. Within this cultural context hallucinations and other psychotic experiences are explained as calling of the ancestors to become THPs. Although the calling is considered as a gift, most people are distressed by it. This three-year follow-up study showed a significant reduction in distress associated with psychotic experiences and a decrease in the frequency of psychotic symptoms compared to the baseline assessment. This insightful study shed light on the trajectory of psychotic experiences, symptoms, and disorders among individuals undergoing the THP apprenticeship in rural South Africa. It highlighted the potential efficacy of a culturally sanctioned healing intervention, in reframing distressing experiences into positive and valued ones. This intervention not only reduced stigma, but also bolstered social empowerment and identity construction among apprentice THPs. This study’s revelations underscore the potential impact of cultural and spiritual practices, emphasizing their role in fostering positive outcomes amidst psychotic experiences. By acknowledging the significance of culturally sanctioned interventions, this study paves the way for a deeper understanding of the beneficial impact of cultural and spiritual elements in mitigating psychosis-related distress and fostering positive trajectories within this context.

Copyright © 2024 Russo and Jovanovic. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

*Correspondence: Manuela Russo, manuela.russo@kcl.ac.uk

†These authors have contributed equally to this work