Rahib L, Smith BD, Aizenberg R, Rosenzweig AB, Fleshman JM, Matrisian LM. Projecting cancer incidence and deaths to 2030: the unexpected burden of thyroid, liver, and pancreas cancers in the United States. Cancer Res. 2014;74(11):2913–21.
Article CAS PubMed Google Scholar
Siegel RL, Miller KD, Jemal A. Cancer statistics, 2017. CA Cancer J Clin. 2017;67(1):7–30.
Yadav D, Lowenfels AB. The epidemiology of pancreatitis and pancreatic cancer. Gastroenterology. 2013;144(6):1252–61.
Saung M, T. L Zheng 39 Current standards of Chemotherapy for Pancreatic Cancer. Clin Ther 11 2125–34.
Mbaveng AT, Kuete V, Efferth T. Potential of Central, Eastern and Western Africa Medicinal plants for Cancer Therapy: spotlight on resistant cells and molecular targets. Front Pharmacol. 2017;8:343.
Article PubMed PubMed Central Google Scholar
Zhu B, Qian C, Zhou F, Guo J, Chen N, Gao C, Jin B, Ding Z. Antipyretic and antitumor effects of a purified polysaccharide from aerial parts of Tetrastigma Hemsleyanum. J Ethnopharmacol. 2020;253:112663.
Article CAS PubMed Google Scholar
Peng X, Zhuang DD, Guo QS. Induction of S phase arrest and apoptosis by ethyl acetate extract from Tetrastigma hemsleyanum in human hepatoma HepG2 cells. Tumour Biol. 2015;36(4):2541–50.
Xiong Y, Wu X, Rao L. Tetrastigma Hemsleyanum (Sanyeqing) root tuber extracts induces apoptosis in human cervical carcinoma HeLa cells. J Ethnopharmacol. 2015;165:46–53.
Article CAS PubMed Google Scholar
Feng Z, Hao W, Lin X, Fan D, Zhou J. Antitumor activity of total flavonoids from Tetrastigma Hemsleyanum Diels et Gilg is associated with the inhibition of regulatory T cells in mice. Onco Targets Ther. 2014;7:947–56.
PubMed PubMed Central Google Scholar
Lin Z, Chen L, Qiu Q, Guo S. Isolation and identification of antiproliferative compounds from the roots of Tetrastigma hemsleyanum against MDA-MB-435S cell lines. Pak J Pharm Sci. 2016;29(4):1171–5.
Klatte DCF, Wallace MB, Löhr M, Bruno MJ, van Leerdam ME. Hereditary pancreatic cancer. Best Pract Res Clin Gastroenterol. 2022;58–9:101783.
Stoffel EM, Brand RE, Goggins M. Pancreatic Cancer: changing Epidemiology and New approaches to Risk Assessment, early detection, and Prevention. Gastroenterology. 2023;164(5):752–65.
Kunk PR, Bauer TW, Slingluff CL, Rahma OE. From bench to bedside a comprehensive review of pancreatic cancer immunotherapy. J Immunother Cancer. 2016;4:14.
Article PubMed PubMed Central Google Scholar
Graham JG, Quinn ML, Fabricant DS, Farnsworth NR. Plants used against cancer - an extension of the work of Jonathan Hartwell. J Ethnopharmacol. 2000;73(3):347–77.
Article CAS PubMed Google Scholar
Amin AR, Kucuk O, Khuri FR, Shin DM. Perspectives for cancer prevention with natural compounds. J Clin Oncol. 2009;27(16):2712–25.
Article PubMed PubMed Central Google Scholar
Xu B, Shen W, Liu X, Zhang T, Ren J, Fan Y, Xu J. Oridonin inhibits BxPC-3 cell growth through cell apoptosis. Acta Biochim Biophys Sin (Shanghai). 2015;47(3):164–73.
Article CAS PubMed Google Scholar
Díaz Osterman CJ, Gonda A, Stiff T, Sigaran U, Valenzuela MM, Ferguson Bennit HR, Moyron RB, Khan S, Wall NR. Curcumin induces pancreatic Adenocarcinoma Cell Death Via reduction of the inhibitors of apoptosis. Pancreas. 2016;45(1):101–9.
Knudsen ES, Kumarasamy V, Nambiar R, Pearson JD, Vail P, Rosenheck H, Wang J, Eng K, Bremner R, Schramek D, Rubin SM, Welm AL, Witkiewicz AK. CDK/cyclin dependencies define extreme cancer cell-cycle heterogeneity and collateral vulnerabilities. Cell Rep. 2022;38(9):110448.
Article CAS PubMed PubMed Central Google Scholar
Zhao W, Zhang L, Zhang Y, Jiang Z, Lu H, Xie Y, Han W, Zhao W, He J, Shi Z, Yang H, Chen J, Chen S, Li Z, Mao J, Zhou L, Gao X, Li W, Tan G, Zhang B, Wang Z. The CDK inhibitor AT7519 inhibits human glioblastoma cell growth by inducing apoptosis, pyroptosis and cell cycle arrest. Cell Death Dis. 2023;14(1):11.
Article PubMed PubMed Central Google Scholar
Bendris N, Lemmers B, Blanchard JM. Cell cycle, cytoskeleton dynamics and beyond: the many functions of cyclins and CDK inhibitors. Cell Cycle. 2015;14(12):1786–98.
Article CAS PubMed PubMed Central Google Scholar
Paterna A, Gomes SE, Borralho PM, Mulhovo S, Rodrigues CM, Ferreira MU. Vobasinyl-iboga alkaloids from Tabernaemontana Elegans: cell cycle arrest and apoptosis-inducing activity in HCT116 Colon cancer cells. J Nat Prod. 2016;79(10):2624–34.
Article CAS PubMed Google Scholar
Kleeff J, Beckhove P, Esposito I, Herzig S, Huber PE, Löhr JM, Friess H. Pancreatic cancer microenvironment. Int J Cancer. 2007;121(4):699–705.
Article CAS PubMed Google Scholar
Razidlo GL, Magnine C, Sletten AC, Hurley RM, Almada LL, Fernandez-Zapico ME, Ji B, McNiven MA. Targeting pancreatic Cancer metastasis by inhibition of Vav1, a driver of Tumor Cell Invasion. Cancer Res. 2015;75(14):2907–15.
Article CAS PubMed PubMed Central Google Scholar
Beuran M, Negoi I, Paun S, Ion AD, Bleotu C, Negoi RI, Hostiuc S. The epithelial to mesenchymal transition in pancreatic cancer: a systematic review. Pancreatology. 2015;15(3):217–25.
Article CAS PubMed Google Scholar
Wang F, Wang Q, Zhou ZW, Yu SN, Pan ST, He ZX, Zhang X, Wang D, Yang YX, Yang T, Sun T, Li M, Qiu JX, Zhou SF. Plumbagin induces cell cycle arrest and autophagy and suppresses epithelial to mesenchymal transition involving PI3K/Akt/mTOR-mediated pathway in human pancreatic cancer cells. Drug Des Devel Ther. 2015;9:537–60.
CAS PubMed PubMed Central Google Scholar
Sun XD, Liu XE, Huang DS. Curcumin reverses the epithelial-mesenchymal transition of pancreatic cancer cells by inhibiting the hedgehog signaling pathway. Oncol Rep. 2013;29(6):2401–7.
Article CAS PubMed Google Scholar
Qin G, Xu F, Qin T, Zheng Q, Shi D, Xia W, Tian Y, Tang Y, Wang J, Xiao X, Deng W, Wang S. Palbociclib inhibits epithelial-mesenchymal transition and metastasis in breast cancer via c-Jun/COX-2 signaling pathway. Oncotarget. 2015;6(39):41794–808.
Article PubMed PubMed Central Google Scholar
Zeisberg M, Neilson EG. Biomarkers for epithelial-mesenchymal transitions. J Clin Invest. 2009;119(6):1429–37.
Article CAS PubMed PubMed Central Google Scholar
Itoh Y. Membrane-type matrix metalloproteinases: their functions and regulations. Matrix Biol. 2015;44–46:207–23.
Pan F, Ma S, Cao W, Liu H, Chen F, Chen X, Shi R. SDF-1α upregulation of MMP-2 is mediated by p38 MAPK signaling in pancreatic cancer cell lines. Mol Biol Rep. 2013;40(7):4139–46.
Article CAS PubMed Google Scholar
Roomi MW, Monterrey JC, Kalinovsky T, Rath M, Niedzwiecki A. In vitro modulation of MMP-2 and MMP-9 in human cervical and ovarian cancer cell lines by cytokines, inducers and inhibitors. Oncol Rep. 2010;23(3):605–14.
Jiang Q, Pan Y, Cheng Y, Li H, Liu D, Li H. Lunasin suppresses the migration and invasion of breast cancer cells by inhibiting matrix metalloproteinase-2/-9 via the FAK/Akt/ERK and NF-κB signaling pathways. Oncol Rep. 2016;36(1):253–62.
Article CAS PubMed Google Scholar
Jiang S, Yan W. Succinate in the cancer-immune cycle. Cancer Lett. 2017;390:45–7.
Article CAS PubMed Google Scholar
Senthil Kumar KJ, Gokila Vani M, Chen CY, Hsiao WW, Li J, Lin ZX, Chu FH, Yen GC, Wang SY. A mechanistic and empirical review of antcins, a new class of phytosterols of formosan fungi origin. J Food Drug Anal. 2020;28(1):38–59.
Article CAS PubMed Google Scholar
Liao P, Wang W, Wang W, Kryczek I, Li X, Bian Y, Sell A, Wei S, Grove S, Johnson JK, Kennedy PD, Gijón M, Shah YM, Zou W. CD8 T cells and fatty acids orchestrate tumor ferroptosis and immunity via ACSL4. Cancer Cell. 2022;40(4):365–78. e6.
Article CAS PubMed PubMed Central Google Scholar
Ma Y, Temkin SM, Hawkridge AM, Guo C, Wang W, Wang XY, Fang X. Fatty acid oxidation: an emerging facet of metabolic transformation in cancer. Cancer Lett. 2018;435:92–100.
Article CAS PubMed PubMed Central Google Scholar
Westheim AJF, Stoffels LM, Dubois LJ, van Bergenhenegouwen J, van Helvoort A, Langen RCJ, Shiri-Sverdlov R, Theys J. Fatty acids as a Tool to boost Cancer Immunotherapy Efficacy. Front Nutr. 2022;9:868436.
Article PubMed PubMed Central Google Scholar
Siegel I, Liu TL, Yaghoubzadeh E, Keskey TS, Gleicher N. Cytotoxic effects of free fatty acids on ascites tumor cells. J Natl Cancer Inst. 1987;78(2):271–7.
Gärtner S, Krüger J, Agh
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