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Topic: Complementary and alternative medicine, Genitourinary cancer
Category: Review
Prostate cancer is the most common cancer in males and one of many types of malignancies that are said to be prevented by drinking green tea and Epigallocatechin-3-gallate (EGCG) intervention. However, epidemiological studies have produced conflicting results regarding the anti-cancer effects of EGCG. In recent years, numerous researchers have demonstrated the effectiveness and safety of green tea polyphenols, including EGCG alone and in combination therapies, through in vivo and in vitro studies. Nevertheless, the molecular mechanisms underlying the anticancer potential of EGCG remain poorly understood. To evaluate the prevention and treatment of prostate cancer, it is critical to have a better understanding of the precise mode of action of EGCG against the growth and progression of prostate cancer. With a focus on the molecular mechanisms of action of EGCG, such as influencing tumour growth, apoptosis, androgen receptor signaling, cell cycle, and various malignant behaviors, we present information regarding the anti-cancer effects of EGCG in the prevention and treatment of prostate cancer in this review.
To cite this article Kumar M. Department of Zoology, Government Degree College Chowari, Chamba, India , Verma S. Department of Zoology, Hans Raj Mahila Maha Vidyalaya, Jalandhar, Punjab, India , Rawat S Department of Biosciences, Himachal Pradesh University, Shimla, Himachal Pardesh, India , Dhatwalia S. K. Department of Medical Microbiology, Postgraduate Institute of Medical Education and Research, Chandigarh, India WCRJ 2024;
11: e2744
DOI: 10.32113/wcrj_20242_2744
Submission date: 24 Aug 2023
Revised on: 03 Oct 2023
Accepted on: 18 Jan 2024
Published online: 12 Feb 2024
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