Koh WJ, Abu-Rustum NR, Bean S, Bradley K, Campos SM, Cho KR, et al. Uterine neoplasms version 1.2018, NCCN clinical practice guidelines in oncology. J Natl Compr Cancer Netw. 2018;16(2):170–99.

Article  Google Scholar 

Siegel RL, Miller KD, Jemal A. Cancer statistics, 2019. CA Cancer J Clin. 2019;69(1):7–34.

Article  PubMed  Google Scholar 

Rezaianzadeh A, Dehghani SL, Mousavi M, Rezaeianzadeh R. The incidence of uterus cancer in Iran: a systematic review. Women’s Health Bull. 2017;4(1):1–4.

Google Scholar 

Sargazi N, Daroudi R, Zendehdel K, Hashemi FA, Tahmasebi M, Darrudi A, et al. Economic burden of gynecological cancers in Iran. Value Health Reg Issues. 2022;28:1–6.

Article  PubMed  Google Scholar 

Vitale SG, Capriglione S, Zito G, Lopez S, Gulino FA, Di Guardo F, et al. Management of endometrial, ovarian and cervical cancer in the elderly: current approach to a challenging condition. Arch Gynecol Obstet. 2019;299(2):299–315.

Article  PubMed  Google Scholar 

Carneiro MM, Lamaita RM, Ferreira MC, Silva-Filho AL. Fertility-preservation in endometrial cancer: is it safe? Review of the literature. JBRA Assist Reprod. 2016;20(4):232–9.

Article  PubMed  PubMed Central  Google Scholar 

Mutlu L, Manavella DD, Gullo G, McNamara B, Santin AD, Patrizio P. Endometrial cancer in reproductive age: fertility-sparing approach and reproductive outcomes. Cancers. 2022;14(21):5187. https://doi.org/10.3390/cancers14215187

Article  CAS  PubMed  PubMed Central  Google Scholar 

Corzo C, Barrientos Santillan N, Westin SN, Ramirez PT. Updates on conservative management of endometrial cancer. J Minim Invasive Gynecol. 2018;25(2):308–13.

Article  PubMed  Google Scholar 

Gunderson CC, Fader AN, Carson KA, Bristow RE. Oncologic and reproductive outcomes with progestin therapy in women with endometrial hyperplasia and grade 1 adenocarcinoma: a systematic review. Gynecol Oncol. 2012;125(2):477–82.

Article  CAS  PubMed  Google Scholar 

Parazzini F, La Vecchia C, Negri E, Riboldi GL, Surace M, Benzi G, et al. Diabetes and endometrial cancer: an Italian case-control study. Int J Cancer. 1999;81(4):539–42.

Article  CAS  PubMed  Google Scholar 

Zhang Z, Dong L, Sui L, Yang Y, Liu X, Yu Y, et al. Metformin reverses progestin resistance in endometrial cancer cells by downregulating GloI expression. Int J Gynecol. 2011;21(2):213–21.

Article  Google Scholar 

Gałczyński K, Olcha P, Romanek-Piva K, Jóźwik M, Semczuk A. Fertility-sparing methods in adolescents affected by endometrial cancer: a comprehensive review. J Clin Med. 2021;10(5):1020. https://doi.org/10.3390/jcm10051020

Article  CAS  PubMed  PubMed Central  Google Scholar 

Carlson MJ, Thiel KW, Yang S, Leslie KK. Catch it before it kills: progesterone, obesity, and the prevention of endometrial cancer. Discov Med. 2012;14(76):215–22.

PubMed  PubMed Central  Google Scholar 

Talmor A, Dunphy B. Female obesity and infertility. Best Pract Res Clin Obstet Gynaecol. 2015;29(4):498–506.

Article  PubMed  Google Scholar 

Cooney LG, Dokras A. Beyond fertility: polycystic ovary syndrome and long-term health. Fertil Steril. 2018;110(5):794–809.

Article  PubMed  Google Scholar 

Wang Y, Yang JX. Fertility-preserving treatment in women with early endometrial cancer: the Chinese experience. Cancer Manag Res. 2018;10:6803–13.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ushijima K, Yahata H, Yoshikawa H, Konishi I, Yasugi T, Saito T, et al. Multicenter phase II study of fertility-sparing treatment with medroxyprogesterone acetate for endometrial carcinoma and atypical hyperplasia in young women. J Clin Oncol. 2007;25(19):2798–803.

Article  CAS  PubMed  Google Scholar 

Imai M, Jobo T, Sato R, Kawaguchi M, Kuramoto H. Medroxyprogesterone acetate therapy for patients with adenocarcinoma of the endometrium who wish to preserve the uterus-usefulness and limitations. Eur J Gynaecol Oncol. 2001;22(3):217–20.

CAS  PubMed  Google Scholar 

Qin Y, Yu Z, Yang J, Cao D, Yu M, Wang Y, et al. Oral Progestin Treatment for Early-Stage Endometrial Cancer: A Systematic Review and Meta-analysis. Int J Gynecol Cancer. 2016;26(6):1081–91.

Article  PubMed  Google Scholar 

Dursun P, Erkanli S, Güzel AB, Gultekin M, Tarhan NC, Altundag O, et al. A Turkish gynecologic oncology group study of fertility-sparing treatment for early-stage endometrial cancer. Int J Gynaecol Obstet. 2012;119(3):270–3.

Article  PubMed  Google Scholar 

Ding Y, Fan Y, Li X, Wang Y, Wang J, Tian L. Metabolic syndrome is an independent risk factor for time to complete remission of fertility-sparing treatment in atypical endometrial hyperplasia and early endometrial carcinoma patients. Reprod Biol Endocrinol. 2022;20(1):134.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ayhan A, Tohma YA, Tunc M. Fertility preservation in early-stage endometrial cancer and endometrial intraepithelial neoplasia: a single-center experience. Taiwan J Obstet Gynecol. 2020;59(3):415–9.

Article  PubMed  Google Scholar 

Chae SH, Shim S-H, Lee SJ, Lee JY, Kim S-N, Kang S-B. Pregnancy and oncologic outcomes after fertility-sparing management for early stage endometrioid endometrial cancer. Int J Gynecol Cancer. 2019;29(1):77.

Article  PubMed  Google Scholar 

Ross RC, Akinde YM, Schauer PR, le Roux CW, Brennan D, Jernigan AM, et al. The role of bariatric and metabolic surgery in the development, diagnosis, and treatment of endometrial cancer. Front Surg. 2022;9:943544.

Article  PubMed  PubMed Central  Google Scholar