Pilot study of frozen platelet extracellular vesicles as a therapeutic agent in hemorrhagic shock in rats

From the Department of Surgery (S.D., L.L., L.B., Ka.M., M.B., C.K., M.L., J.G., M.S.), Oregon Health & Science University, Portland, Oregon; Department of Laboratory Medicine (A.F., B.M., A.T., L.K., S.P.), University of California San Francisco, San Francisco, California; and Cellphire Therapeutics, Inc. (M.M., B.K., Ke.M., M.F.), Rockville, Maryland.

Submitted: August 22, 2023, Revised: October 10, 2023, Accepted: October 31, 2023, Published online: November 27, 2023.

This study was presented at the 82nd annual meeting of the American Association for the Surgery of Trauma, September 20th, 2023 in Anaheim, California.

Supplemental digital content is available for this article. Direct URL citations appear in the printed text, and links to the digital files are provided in the HTML text of this article on the journal’s Web site (www.jtrauma.com).

Address for correspondence: Samantha Durbin, MD, Oregon Health & Science University, 3181 S.W. Sam Jackson Park Road, Mail Code: L611, Portland, OR 97239; email: [email protected]; Martin A. Schreiber, MD, Oregon Health & Science University, 3181 S.W. Sam Jackson Park Road, Mail Code: L611, Portland, OR 97239; email: [email protected].

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