1Icahn School of Medicine at Mount Sinai, NY, NY 10029

2Rila Therapeutics Inc., South San Francisco, CA 94080

3ShangPharma Innovations Inc., South San Francisco, CA 94080

aCorresponding authors: John Cijiang He, M.D./Ph.D. or Kyung Lee, Ph.D. Division of Nephrology, Box 1243 Icahn School of Medicine at Mount Sinai One Gustave L. Levy Place New York NY 10029 Tel: 212-659-1703, Fax: 212-987-0389 Email: [email protected] or [email protected]