Analysis and Regulatory Mechanisms of Platelet-Related Genes in Patients with Ischemic Stroke

Agayeva N, Topcuoglu MA, Arsava EM (2016) The interplay between stroke severity, antiplatelet use, and aspirin resistance in ischemic stroke. J Stroke Cerebrovasc Dis 25(2):397–403. https://doi.org/10.1016/j.jstrokecerebrovasdis.2015.10.011

Article  PubMed  Google Scholar 

Alkarithi G, Duval C, Shi Y, Macrae FL, Ariens RAS (2021) Thrombus structural composition in cardiovascular disease. Arterioscler Thromb Vasc Biol 41(9):2370–2383. https://doi.org/10.1161/ATVBAHA.120.315754

Article  CAS  PubMed  PubMed Central  Google Scholar 

AlKhater SA (2016) CNS vasculitis and stroke as a complication of DOCK8 deficiency: a case report. BMC Neurol 16:54. https://doi.org/10.1186/s12883-016-0578-3

Article  CAS  PubMed  PubMed Central  Google Scholar 

Anand S, Khan MA, Zubair H, Sudan SK, Vikramdeo KS, Deshmukh SK, Azim S, Srivastava SK, Singh S, Singh AP (2023) MYB sustains hypoxic survival of pancreatic cancer cells by facilitating metabolic reprogramming. EMBO Rep 24(3):e55643. https://doi.org/10.15252/embr.202255643

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ashayeri Ahmadabad R, Mirzaasgari Z, Gorji A, Khaleghi Ghadiri M (2021) Toll-like receptor signaling pathways: novel therapeutic targets for cerebrovascular disorders. Int J Mol Sci. https://doi.org/10.3390/ijms22116153

Article  PubMed  PubMed Central  Google Scholar 

Brunekreeft KL, Paijens ST, Wouters MCA, Komdeur FL, Eggink FA, Lubbers JM, Workel HH, Van Der Slikke EC, Propper NEJ, Leffers N, Adam J, Pijper H, Plat A, Kol A, Nijman HW, De Bruyn M (2020) Deep immune profiling of ovarian tumors identifies minimal MHC-I expression after neoadjuvant chemotherapy as negatively associated with T-cell-dependent outcome. Oncoimmunology 9(1):1760705. https://doi.org/10.1080/2162402X.2020.1760705

Article  PubMed  PubMed Central  Google Scholar 

Chavez JC, Foss FM, William BM, Brammer JE, Smith SM, Prica A, Zain JM, Tuscano JM, Shah H, Mehta-Shah N, Ramakrishnan Geethakumari PR, Wang BX, Zantinge S, Wang L, Zhang L, Boutrin A, Zhao W, Cheng L, Standifer N, Hewitt L, Enowtambong E, Shao W, Sharma S, Carlesso G, Moscow JA, Siu LL (2023) Targeting the inducible T-cell costimulator (ICOS) in patients with relapsed/refractory T-follicular helper phenotype peripheral T-cell and angioimmunoblastic T-cell lymphoma. Clin Cancer Res. https://doi.org/10.1158/1078-0432.CCR-22-2955

Article  PubMed  PubMed Central  Google Scholar 

Chen CM, Wu CT, Yang TH, Liu SH, Yang FY (2018) Preventive effect of low intensity pulsed ultrasound against experimental cerebral ischemia/reperfusion injury via apoptosis reduction and brain-derived neurotrophic factor induction. Sci Rep 8(1):5568. https://doi.org/10.1038/s41598-018-23929-8

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cheng X, Xie NC, Xu HL, Chen C, Lian YJ (2017) Biochemical aspirin resistance is associated with increased stroke severity and infarct volumes in ischemic stroke patients. Oncotarget 8(44):77086–77095. https://doi.org/10.18632/oncotarget.20356

Article  PubMed  PubMed Central  Google Scholar 

Cheng X, Ferino E, Hull H, Jickling GC, Ander BP, Stamova B, Sharp FR (2019) Smoking affects gene expression in blood of patients with ischemic stroke. Ann Clin Transl Neurol 6(9):1748–1756. https://doi.org/10.1002/acn3.50876

Article  CAS  PubMed  PubMed Central  Google Scholar 

Colaprico A, Silva TC, Olsen C, Garofano L, Cava C, Garolini D, Sabedot TS, Malta TM, Pagnotta SM, Castiglioni I, Ceccarelli M, Bontempi G, Noushmehr H (2016) TCGAbiolinks: an R/Bioconductor package for integrative analysis of TCGA data. Nucleic Acids Res 44(8):e71. https://doi.org/10.1093/nar/gkv1507

Article  CAS  PubMed  Google Scholar 

Cui Y, Zhang Y, Zhao X, Shao L, Liu G, Sun C, Xu R, Zhang Z (2021) ACSL4 exacerbates ischemic stroke by promoting ferroptosis-induced brain injury and neuroinflammation. Brain Behav Immun 93:312–321. https://doi.org/10.1016/j.bbi.2021.01.003

Article  CAS  PubMed  Google Scholar 

Dueker ND, Doliner B, Gardener H, Dong C, Beecham A, Della-Morte D, Sacco RL, Blanton SH, Wang L, Rundek T (2020) Extreme phenotype approach suggests taste transduction pathway for carotid plaque in a multi-ethnic cohort. Stroke 51(9):2761–2769. https://doi.org/10.1161/STROKEAHA.120.028979

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fadakar K, Dadkhahfar S, Esmaeili A, Rezaei N (2014) The role of Toll-like receptors (TLRs) in stroke. Rev Neurosci 25(5):699–712. https://doi.org/10.1515/revneuro-2013-0069

Article  CAS  PubMed  Google Scholar 

Friedman J, Hastie T, Tibshirani R (2010) Regularization paths for generalized linear models via coordinate descent. J Stat Softw 33(1):1–22

Article  PubMed  PubMed Central  Google Scholar 

Giannini G, Ambrosini MI, Di Marcotullio L, Cerignoli F, Zani M, MacKay AR, Screpanti I, Frati L, Gulino A (2003) EGF- and cell-cycle-regulated STAG1/PMEPA1/ERG1.2 belongs to a conserved gene family and is overexpressed and amplified in breast and ovarian cancer. Mol Carcinog 38(4):188–200. https://doi.org/10.1002/mc.10162

Article  CAS  PubMed  Google Scholar 

Huang Y, Wang Y, Liu X, Ouyang Y (2021) Silencing lncRNA HOTAIR improves the recovery of neurological function in ischemic stroke via the miR-148a-3p/KLF6 axis. Brain Res Bull 176:43–53. https://doi.org/10.1016/j.brainresbull.2021.08.003

Article  CAS  PubMed  Google Scholar 

Huang C, Wang C, Zhang W, Yang T, Xia M, Lei X, Peng Y, Wu Y, Feng J, Li D, Zhang G (2022) Preparation, in vitro and in vivo evaluation of nanoemulsion in situ gel for transnasal delivery of traditional Chinese medicine volatile oil from Ligusticum sinense Oliv.cv. Chaxiong. Molecules. https://doi.org/10.3390/molecules27217644

Article  PubMed  PubMed Central  Google Scholar 

Iadecola C, Anrather J (2011) The immunology of stroke: from mechanisms to translation. Nat Med 17(7):796–808. https://doi.org/10.1038/nm.2399

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ji X, Song B, Zhu H, Jiang Z, Hua F, Wang S, Zhou J, Li L, Dai C, Zhang M, Wei D, Zhang L, Zhang X, Zhang Q, Chen P (2023) A study on endovascular treatment alone and bridging treatment for acute ischemic stroke. Eur J Med Res 28(1):12. https://doi.org/10.1186/s40001-022-00966-8

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jin ZL, Gao WY, Liao SJ, Yu T, Shi Q, Yu SZ, Cai YF (2021) Paeonol inhibits the progression of intracerebral haemorrhage by mediating the HOTAIR/UPF1/ACSL4 axis. ASN Neuro 13:17590914211010648. https://doi.org/10.1177/17590914211010647

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jolugbo P, Ariens RAS (2021) Thrombus composition and efficacy of thrombolysis and thrombectomy in acute ischemic stroke. Stroke 52(3):1131–1142. https://doi.org/10.1161/STROKEAHA.120.032810

Article  CAS  PubMed  PubMed Central  Google Scholar 

Khamphaya T, Chukijrungroat N, Saengsirisuwan V, Mitchell-Richards KA, Robert ME, Mennone A, Ananthanarayanan M, Nathanson MH, Weerachayaphorn J (2018) Nonalcoholic fatty liver disease impairs expression of the type II inositol 1, 4, 5-trisphosphate receptor. Hepatology 67(2):560–574. https://doi.org/10.1002/hep.29588

Article  CAS  PubMed  Google Scholar 

Koupenova M, Clancy L, Corkrey HA, Freedman JE (2018) Circulating platelets as mediators of immunity, inflammation, and thrombosis. Circ Res 122(2):337–351. https://doi.org/10.1161/CIRCRESAHA.117.310795

Article  CAS  PubMed  PubMed Central  Google Scholar 

Langfelder P, Horvath S (2008) WGCNA: an R package for weighted correlation network analysis. BMC Bioinform 9:559. https://doi.org/10.1186/1471-2105-9-559

Article  CAS  Google Scholar 

Li T, Huang C, Ma J, Ding R, Zhang Q, Wang W (2022) Identification of inflammation-related genes and exploration of regulatory mechanisms in patients with osteonecrosis of the femoral head. Biomed Res Int 2022:4501186. https://doi.org/10.1155/2022/4501186

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu R, Song P, Gu X, Liang W, Sun W, Hua Q, Zhang Y, Qiu Z (2021) Comprehensive landscape of immune infiltration and aberrant pathway activation in ischemic stroke. Front Immunol 12:766724. https://doi.org/10.3389/fimmu.2021.766724

Article  CAS  PubMed  Google Scholar 

Longstaff C, Varju I, Sotonyi P, Szabo L, Krumrey M, Hoell A, Bota A, Varga Z, Komorowicz E, Kolev K (2013) Mechanical stability and fibrinolytic resistance of clots containing fibrin, DNA, and histones. J Biol Chem 288(10):6946–6956. https://doi.org/10.1074/jbc.M112.404301

Article  CAS  PubMed  PubMed Central  Google Scholar 

Luo H, Li X, Jiang A, Zhang B, Bi P, Dong Y, Guo Y (2019) Associations of beta-fibrinogen polymorphisms with the risk of ischemic stroke: a meta-analysis. J Stroke Cerebrovasc Dis 28(2):243–250. https://doi.org/10.1016/j.jstrokecerebrovasdis.2018.09.007

Article  PubMed  Google Scholar 

Miro-Mur F, Urra X, Gallizioli M, Chamorro A, Planas AM (2016) Antigen presentation after stroke. Neurotherapeutics 13(4):719–728. https://doi.org/10.1007/s13311-016-0469-8

Article  CAS  PubMed  PubMed Central 

Comments (0)

No login
gif