Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71:209–49.
Bang YJ, Van Cutsem E, Feyereislova A, Chung HC, Shen L, Sawaki A, et al. Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial. Lancet. 2010;376:687–97.
Article CAS PubMed Google Scholar
Gomez-Martin C, Plaza JC, Pazo-Cid R, Salud A, Pons F, Fonseca P, et al. Level of HER2 gene amplification predicts response and overall survival in HER2-positive advanced gastric cancer treated with trastuzumab. J Clin Oncol. 2013;31:4445–52.
Article CAS PubMed Google Scholar
Burrell RA, McGranahan N, Bartek J, Swanton C. The causes and consequences of genetic heterogeneity in cancer evolution. Nature. 2013;501:338–45.
Article CAS PubMed Google Scholar
Renovanz M, Kim EL. Intratumoral heterogeneity, its contribution to therapy resistance and methodological caveats to assessment. Front Oncol. 2014;4:142.
Article PubMed PubMed Central Google Scholar
Cioce M, Sacconi A, Pass HI, Canino C, Strano S, Blandino G, et al. Insights into intra-tumoral heterogeneity: transcriptional profiling of chemoresistant MPM cell subpopulations reveals involvement of NFkB and DNA repair pathways and contributes a prognostic signature. Int J Mol Sci. 2021;22:12071.
Article CAS PubMed PubMed Central Google Scholar
Hajjaji N, Abbouchi M, Nguyen LA, Charles S, Leclercq S, Bertin D, et al. A novel proteomic mass spectrometry-based approach to reveal functionally heterogeneous tumor clones in breast cancer metastases and identify clone-specific drug targets. J Clin Oncol. 2020;38:e13063.
Ho SWT, Tan P. Dissection of gastric cancer heterogeneity for precision oncology. Cancer Sci. 2019;110:3405–14.
Article CAS PubMed PubMed Central Google Scholar
Pectasides E, Stachler MD, Derks S, Liu Y, Maron S, Islam M, et al. Genomic heterogeneity as a barrier to precision medicine in gastroesophageal adenocarcinoma. Cancer Discov. 2018;8:37–48.
Article CAS PubMed Google Scholar
Zhang M, Hu S, Min M, Ni Y, Lu Z, Sun X, et al. Dissecting transcriptional heterogeneity in primary gastric adenocarcinoma by single cell RNA sequencing. Gut. 2021;70:464–75.
Article CAS PubMed Google Scholar
Gambardella V, Fleitas T, Tarazona N, Cejalvo JM, Gimeno-Valiente F, Martinez-Ciarpaglini C, et al. Towards precision oncology for HER2 blockade in gastroesophageal adenocarcinoma. Ann Oncol. 2019;30:1254–64.
Article CAS PubMed Google Scholar
Lee HE, Park KU, Yoo SB, Nam SK, Park DJ, Kim HH, et al. Clinical significance of intratumoral HER2 heterogeneity in gastric cancer. Eur J Cancer. 2013;49:1448–57.
Article CAS PubMed Google Scholar
Yagi S, Wakatsuki T, Yamamoto N, Chin K, Takahari D, Ogura M, et al. Clinical significance of intratumoral HER2 heterogeneity on trastuzumab efficacy using endoscopic biopsy specimens in patients with advanced HER2 positive gastric cancer. Gastric Cancer. 2019;22:518–25.
Article CAS PubMed Google Scholar
Balluff B, Frese CK, Maier SK, Schone C, Kuster B, Schmitt M, et al. De novo discovery of phenotypic intratumour heterogeneity using imaging mass spectrometry. J Pathol. 2015;235:3–13.
Article CAS PubMed Google Scholar
Chao J, Bedell V, Lee J, Li MS, Chu P, Yuan YC, et al. Association between spatial heterogeneity within nonmetastatic gastroesophageal adenocarcinomas and survival. JAMA Netw Open. 2020;3:e203652.
Article PubMed PubMed Central Google Scholar
Abdelmoula WM, Balluff B, Englert S, Dijkstra J, Reinders MJ, Walch A, et al. Data-driven identification of prognostic tumor subpopulations using spatially mapped t-SNE of mass spectrometry imaging data. Proc Natl Acad Sci USA. 2016;113:12244–9.
Article CAS PubMed PubMed Central Google Scholar
Zhang Z, Bao C, Jiang L, Wang S, Wang K, Lu C, et al. When cancer drug resistance meets metabolomics (bulk, single-cell and/or spatial): Progress, potential, and perspective. Front Oncol. 2022;12:1054233.
Article CAS PubMed Google Scholar
Wei S, Liu L, Zhang J, Bowers J, Gowda GA, Seeger H, et al. Metabolomics approach for predicting response to neoadjuvant chemotherapy for breast cancer. Mol Oncol. 2013;7:297–307.
Article CAS PubMed Google Scholar
Yang K, Zhang F, Han P, Wang ZZ, Deng K, Zhang YY, et al. Metabolomics approach for predicting response to neoadjuvant chemotherapy for colorectal cancer. Metabolomics. 2018;14:110.
Wang J, Kunzke T, Prade VM, Shen J, Buck A, Feuchtinger A, et al. Spatial metabolomics identifies distinct tumor-specific subtypes in gastric cancer patients. Clin Cancer Res. 2022;28:2865–77.
Article CAS PubMed Google Scholar
Kunzke T, Holzl FT, Prade VM, Buck A, Huber K, Feuchtinger A, et al. Metabolomic therapy response prediction in pretherapeutic tissue biopsies for trastuzumab in patients with HER2-positive advanced gastric cancer. Clin Transl Med. 2021;11:e547.
Article CAS PubMed PubMed Central Google Scholar
Prade VM, Kunzke T, Feuchtinger A, Rohm M, Luber B, Lordick F, et al. De novo discovery of metabolic heterogeneity with immunophenotype-guided imaging mass spectrometry. Mol Metab. 2020;36:100953.
Article CAS PubMed PubMed Central Google Scholar
Balluff B, Rauser S, Ebert MP, Siveke JT, Hofler H, Walch A. Direct molecular tissue analysis by MALDI imaging mass spectrometry in the field of gastrointestinal disease. Gastroenterology. 2012;143:544–9.e2.
Article CAS PubMed Google Scholar
Aichler M, Walch A. MALDI imaging mass spectrometry: current frontiers and perspectives in pathology research and practice. Lab Invest. 2015;95:422–31.
Article CAS PubMed Google Scholar
Shen J, Sun N, Wang J, Zens P, Kunzke T, Buck A, et al. Patterns of carbon-bound exogenous compounds impact disease pathophysiology in lung cancer subtypes in different ways. ACS Nano. 2023;17:16396–411.
Article CAS PubMed PubMed Central Google Scholar
Addie RD, Balluff B, Bovee JV, Morreau H, McDonnell LA. Current state and future challenges of mass spectrometry imaging for clinical research. Anal Chem. 2015;87:6426–33.
Article CAS PubMed Google Scholar
Oppenheimer SR, Mi D, Sanders ME, Caprioli RM. Molecular analysis of tumor margins by MALDI mass spectrometry in renal carcinoma. J Proteome Res. 2010;9:2182–90.
Article CAS PubMed PubMed Central Google Scholar
Kulbe H, Klein O, Wu Z, Taube ET, Kassuhn W, Horst D, et al. Discovery of prognostic markers for early-stage high-grade serous ovarian cancer by MALDI-imaging. Cancers. 2020;12:2000.
Article CAS PubMed PubMed Central Google Scholar
Cornett DS, Reyzer ML, Chaurand P, Caprioli RM. MALDI imaging mass spectrometry: molecular snapshots of biochemical systems. Nat Methods. 2007;4:828–33.
Article CAS PubMed Google Scholar
Shen J, Sun N, Zens P, Kunzke T, Buck A, Prade VM, et al. Spatial metabolomics for evaluating response to neoadjuvant therapy in non-small cell lung cancer patients. Cancer Commun. 2022;42:517–35.
Deininger SO, Ebert MP, Futterer A, Gerhard M, Rocken C. MALDI imaging combined with hierarchical clustering as a new tool for the interpretation of complex human cancers. J Proteome Res. 2008;7:5230–6.
Article CAS PubMed Google Scholar
Jones EA, Schmitz N, Waaijer CJ, Frese CK, van Remoortere A, van Zeijl RJ, et al. Imaging mass spectrometry-based molecular histology differentiates microscopically identical and heterogeneous tumors. J Proteome Res. 2013;12:1847–55.
Article CAS PubMed Google Scholar
Wang J, Sun N, Kunzke T, Shen J, Zens P, Prade VM, et al. Spatial metabolomics identifies distinct tumor-specific and stroma-specific subtypes in patients with lung squamous cell carcinoma. NPJ Precis Oncol. 2023;7:114.
Article CAS PubMed PubMed Central Google Scholar
Haffner I, Schierle K, Raimundez E, Geier B, Maier D, Hasenauer J, et al. HER2 expression, test deviations, and their impact on survival in metastatic gastric cancer: results from the prospective multicenter VARIANZ study. J Clin Oncol. 2021;39:1468–78.
Article CAS PubMed PubMed Central Google Scholar
Ly A, Buck A, Balluff B, Sun N, Gorzolka K, Feuchtinger A, et al. High-mass-resolution MALDI mass spectrometry imaging of metabolites from formalin-fixed paraffin-embedded tissue. Nat Protoc. 2016;11:1428–43.
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