Albendazole inhibits colon cancer progression and therapy resistance by targeting ubiquitin ligase RNF20

Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin. 2021;71:209–49.

Article  PubMed  Google Scholar 

Fatima I, Uppada JP, Chhonker YS, Gowrikumar S, Barman S, Roy S, et al. Identification and characterization of a first-generation inhibitor of claudin-1 in colon cancer progression and metastasis. Biomed Pharmacother. 2023;159:114255.

Article  CAS  PubMed  Google Scholar 

Miller KD, Nogueira L, Devasia T, Mariotto AB, Yabroff KR, Jemal A, et al. Cancer treatment and survivorship statistics, 2022. CA Cancer J Clin. 2022;72:409–36.

Article  PubMed  Google Scholar 

Siegel RL, Miller KD, Wagle NS, Jemal A. Cancer statistics, 2023. CA Cancer J Clin. 2023;73:17–48.

Article  PubMed  Google Scholar 

Ciardiello F, Ciardiello D, Martini G, Napolitano S, Tabernero J, Cervantes A. Clinical management of metastatic colorectal cancer in the era of precision medicine. CA Cancer J Clin. 2022;72:372–401.

Article  PubMed  Google Scholar 

Xie YH, Chen YX, Fang JY. Comprehensive review of targeted therapy for colorectal cancer. Signal Transduct Target Ther. 2020;5:22.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Modest DP, Rivera F, Bachet JB, de Braud F, Pietrantonio F, Koukakis R, et al. Panitumumab-based maintenance after oxaliplatin discontinuation in metastatic colorectal cancer: A retrospective analysis of two randomised trials. Int J Cancer. 2019;145:576–85.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hu T, Li Z, Gao CY, Cho CH. Mechanisms of drug resistance in colon cancer and its therapeutic strategies. World J Gastroenterol. 2016;22:6876–89.

Article  CAS  PubMed  PubMed Central  Google Scholar 

El Zarif T, Yibirin M, De Oliveira-Gomes D, Machaalani M, Nawfal R, Bittar G, et al. Overcoming Therapy Resistance in Colon Cancer by Drug Repurposing. Cancers (Basel). 2022;14:2105.

Article  CAS  PubMed  Google Scholar 

Yeu Y, Yoon Y, Park S. Protein localization vector propagation: a method for improving the accuracy of drug repositioning. Mol Biosyst. 2015;11:2096–102.

Article  CAS  PubMed  Google Scholar 

Scannell JW, Blanckley A, Boldon H, Warrington B. Diagnosing the decline in pharmaceutical R&D efficiency. Nat Rev Drug Discov. 2012;11:191–200.

Article  CAS  PubMed  Google Scholar 

Horton J. Albendazole: a review of anthelmintic efficacy and safety in humans. Parasitology. 2000;121:S113–S132.

Article  PubMed  Google Scholar 

Conterno LO, Turchi MD, Correa I, Monteiro, de Barros Almeida RA. Anthelmintic drugs for treating ascariasis. Cochrane Database Syst Rev. 2020;4:CD010599.

PubMed  Google Scholar 

Zhou F, Du J, Wang J. Albendazole inhibits HIF-1alpha-dependent glycolysis and VEGF expression in non-small cell lung cancer cells. Mol Cell Biochem. 2017;428:171–8.

Article  CAS  PubMed  Google Scholar 

Pourgholami MH, Cai ZY, Wang L, Badar S, Links M, Morris DL. Inhibition of cell proliferation, vascular endothelial growth factor and tumor growth by albendazole. Cancer Invest. 2009;27:171–7.

Article  CAS  PubMed  Google Scholar 

Pourgholami MH, Cai ZY, Badar S, Wangoo K, Poruchynsky MS, Morris DL. Potent inhibition of tumoral hypoxia-inducible factor 1alpha by albendazole. BMC Cancer. 2010;10:143.

Article  PubMed  PubMed Central  Google Scholar 

Pourgholami MH, Khachigian LM, Fahmy RG, Badar S, Wang L, Chu SW, et al. Albendazole inhibits endothelial cell migration, tube formation, vasopermeability, VEGF receptor-2 expression and suppresses retinal neovascularization in ROP model of angiogenesis. Biochem Biophys Res Commun. 2010;397:729–34.

Article  CAS  PubMed  Google Scholar 

Wang LJ, Lee YC, Huang CH, Shi YJ, Chen YJ, Pei SN, et al. Non-mitotic effect of albendazole triggers apoptosis of human leukemia cells via SIRT3/ROS/p38 MAPK/TTP axis-mediated TNF-alpha upregulation. Biochem Pharm. 2019;162:154–68.

Article  CAS  PubMed  Google Scholar 

Patel K, Doudican NA, Schiff PB, Orlow SJ. Albendazole sensitizes cancer cells to ionizing radiation. Radiat Oncol. 2011;6:160.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jung YY, Baek SH, Ha IJ, Ahn KS. Regulation of apoptosis and autophagy by albendazole in human colon adenocarcinoma cells. Biochimie. 2022;198:155–66.

Article  CAS  PubMed  Google Scholar 

Pourgholami MH, Akhter J, Wang L, Lu Y, Morris DL. Antitumor activity of albendazole against the human colorectal cancer cell line HT-29: in vitro and in a xenograft model of peritoneal carcinomatosis. Cancer Chemother Pharm. 2005;55:425–32.

Article  CAS  Google Scholar 

Gowrikumar S, Primeaux M, Pravoverov K, Wu C, Szeglin BC, Sauve CG, et al. A claudin-based molecular signature identifies high-risk, chemoresistant colorectal cancer patients. Cells. 2021;10:2211.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sato T, Stange DE, Ferrante M, Vries RG, Van Es JH, Van den Brink S, et al. Long-term expansion of epithelial organoids from human colon, adenoma, adenocarcinoma, and Barrett’s epithelium. Gastroenterology. 2011;141:1762–72.

Article  CAS  PubMed  Google Scholar 

Fatima I, Barman S, Uppada J, Chauhan S, Rauth S, Rachagani S, et al. MASTL regulates EGFR signaling to impact pancreatic cancer progression. Oncogene. 2021;40:5691–704.

Article  CAS  PubMed  PubMed Central  Google Scholar 

New-Aaron M, Koganti SS, Ganesan M, Kanika S, Kumar V, Wang W, et al. Hepatocyte-specific triggering of hepatic stellate cell profibrotic activation by apoptotic bodies: the role of hepatoma-derived growth factor, HIV, and ethanol. Int J Mol Sci. 2023;24:5346.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fatima I, Saxena R, Kharkwal G, Hussain MK, Yadav N, Hajela K, et al. The anti-proliferative effect of 2-[piperidinoethoxyphenyl]-3-[4-hydroxyphenyl]-2H-benzo(b) pyran is potentiated via induction of estrogen receptor beta and p21 in human endometrial adenocarcinoma cells. J Steroid Biochem Mol Biol. 2013;138:123–31.

Article  CAS  PubMed  Google Scholar 

Fatima I, El-Ayachi I, Taotao L, Lillo MA, Krutilina RI, Seagroves TN, et al. The natural compound Jatrophone interferes with Wnt/beta-catenin signaling and inhibits proliferation and EMT in human triple-negative breast cancer. PLoS One. 2017;12:e0189864.

Article  PubMed  PubMed Central  Google Scholar 

Kumar B, Ahmad R, Sharma S, Gowrikumar S, Primeaux M, Rana S, et al. PIK3C3 inhibition promotes sensitivity to colon cancer therapy by inhibiting cancer stem cells. Cancers (Basel). 2021;13:2168.

Article  CAS  PubMed  Google Scholar 

Luzak B, Siarkiewicz P, Boncler M. An evaluation of a new high-sensitivity PrestoBlue assay for measuring cell viability and drug cytotoxicity using EA.hy926 endothelial cells. Toxicol Vitr. 2022;83:105407.

Article  CAS  Google Scholar 

Kaemmerer E, Klaus C, Jeon MK, Gassler N. Molecular classification of colorectal carcinomas: the genotype-to-phenotype relation. World J Gastroenterol. 2013;19:8163–7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhu L, Yang Q, Hu R, Li Y, Peng Y, Liu H, et al. Novel therapeutic strategy for melanoma based on albendazole and the CDK4/6 inhibitor palbociclib. Sci Rep. 2022;12:5706.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Petersen J, Baird SK. Treatment of breast and colon cancer cell lines with anti-helmintic benzimidazoles mebendazole or albendazole results in selective apoptotic cell death. J Cancer Res Clin Oncol. 2021;147:2945–53.

Article  CAS  PubMed  Google Scholar 

Fatima I, El-Ayachi I, Taotao L, Angeles Lillo M, Krutilina RI, Seagroves TN, et al. Correction: The natural compound Jatrophone interferes with Wnt/beta-catenin signaling and inhibits proliferation and EMT in human triple-negative breast cancer. PLoS One. 2018;13:e0197796.

Article  PubMed  PubMed Central  Google Scholar 

Xia W, Spector S, Hardy L, Zhao S, Saluk A, Alemane L, et al. Tumor selective G2/M cell cycle arrest and apoptosis of epithelial and hematological malignancies by BBL22, a benzazepine. Proc Natl Acad Sci USA. 2000;97:7494–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hulkower KI, Herber RL. Cell migration and invasion assays as tools for drug discovery. Pharmaceutics. 2011;3:107–24.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kowtharapu BS, Murin R, Junemann AGM, Stachs O. Role of corneal stromal cells on epithelial cell function during wound healing. Int J Mol Sci. 2018;19:464.

Arti

Comments (0)

No login
gif