A highly effective and selective FeBr3 promoted deuterium bromination/cyclization of 1,n-enynes is reported. On one hand, the Lewis acid FeBr3 as catalyst, promoted cyclization of 1,n-enynes to afford cyclization with high efficiency. On the other hand, FeBr3 serves as the bromine source (with D2O as deuterium source) to promote the desired deuterated pyrrole derivatives containing alkenyl bromide groups. This protocol provides an effective pathway to afford deuterated alkenyl brominative compounds in (Z)-isomers with high yields and selectivity and a new way to introduce 2H into organic compounds.

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