1Department of Pediatrics, University of Pittsburgh School of Medicine, University of Pittsburgh Medical Center Children’s Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, Pennsylvania;

2Buck Institute for Research on Aging, Novato, California.

aCorresponding author: Dr. Sunder Sims-Lucas or Dr. Eric S. Goetzman, Department of Pediatrics, University of Pittsburgh School of Medicine, UPMC Children’s Hospital of Pittsburgh, University of Pittsburgh, 4401 Penn Avenue, Pittsburgh, PA 15224. E-mail: [email protected] or [email protected]