A clinical approach to the investigation and management of long COVID associated neuropathic pain

World Health Organization (WHO) (2021) A clinical case definition of post COVID-19 condition by a Delphi consensus, 6 October 2021. https://www.who.int/publications/i/item/WHO-2019-nCoV-Post_COVID-19_condition-Clinical_case_definition-2021.1

Lopez-Leon S, Wegman-Ostrosky T, Perelman C, Sepulveda R, Rebolledo PA, Cuapio A, Villapol S (2021) More than 50 long-term effects of COVID-19: a systematic review and meta-analysis. Sci Rep 11:16144. https://doi.org/10.1038/s41598-021-95565-8

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fernández-de-las-Peñas C, Palacios-Ceña D, Gómez-Mayordomo V, Florencio LL, Cuadrado ML, Plaza-Manzano G, Navarro-Santana M (2021) Prevalence of Post-COVID-19 symptoms in hospitalized and non-hospitalized COVID-19 survivors: a systematic review and meta-analysis. Eur J Int Med 92:55–70. https://doi.org/10.1016/j.ejim.2021.06.009

Article  CAS  Google Scholar 

Fernández-de-las-Peñas C, Navarro-Santana M, Plaza-Manzano G, Palacios-Ceña A-N (2022) Time course prevalence of post-COVID pain symptoms of musculoskeletal origin in patients who had survived to SARS-CoV-2 infection: a systematic review and meta-analysis. Pain 163:1220–1231. https://doi.org/10.1097/j.pain.0000000000002496

Article  CAS  PubMed  Google Scholar 

Fernández-de-las-Peñas C, de-la-Llave-Rincón AI, Ortega-Santiago R, Ambite-Quesada S, Gómez-Mayordomo V, Cuadrado ML, Arias-Navalón JA, Hernández-Barrera V, Martín-Guerrero JD, Pellicer-Valero OJ, et al (2021) Prevalence and risk factors of musculoskeletal pain symptoms as long-term post-COVID sequelae in hospitalized COVID-19 survivors: a multicenter study. Pain https://doi.org/10.1097/j.pain.0000000000002564

NICE (2022) COVID-19 rapid guideline: managing the long-term effects of COVID-19. National Institute for Health and Care Excellence. https://www.nice.org.uk [Free Full-text]

Ray STJ, Abdel-Mannan O, Sa M, Fuller C, Wood GK, Pysden K, Yoong M, McCullagh H, Scott D, McMahon M, Thomas N, Taylor M, Illingworth M, McCrea N, Davies V, Whitehouse W, Zuberi S, Guthrie K, Wassmer E, Shah N, Baker MR, Tiwary S, Tan HJ, Varma U, Ram D, Avula S, Enright N, Hassell J, Ross Russell AL, Kumar R, Mulholland RE, Pett S, Galea I, Thomas RH, Lim M, Hacohen Y, Solomon T, Griffiths MJ, Michael BD, Kneen R; CoroNerve study group. Neurological manifestations of SARS-CoV-2 infection in hospitalised children and adolescents in the UK: a prospective national cohort study. Lancet Child Adolesc Health. 2021;5(9):631–641. https://doi.org/10.1016/S2352-4642(21)00193-0. Erratum in: Lancet Child Adolesc Health. 2021; Erratum in: Lancet Child Adolesc Health. 2021;5(12):e46

Ross Russell AL, Hardwick M, Jeyanantham A, White LM, Deb S, Burnside G, Joy HM, Smith CJ, Pollak TA, Nicholson TR, Davies NWS, Manji H, Easton A, Ray S, Zandi MS, Coles JP, Menon DK, Varatharaj A, McCausland B, Ellul MA, Thomas N, Breen G, Keddie S, Lunn MP, Burn JPS, Quattrocchi G, Dixon L, Rice CM, Pengas G, Al-Shahi Salman R, Carson A, Joyce EM, Turner MR, Benjamin LA, Solomon T, Kneen R, Pett S, Thomas RH, Michael BD, Galea I (2021) Spectrum, risk factors and outcomes of neurological and psychiatric complications of COVID-19: a UK-wide cross-sectional surveillance study. Brain Commun. https://doi.org/10.1093/braincomms/fcab168

Article  PubMed  PubMed Central  Google Scholar 

Varatharaj A, Thomas N, Ellul MA, Davies NWS, Pollak TA, Tenorio EL, Sultan M, Easton A, Breen G, Zandi M, Coles JP, Manji H, Al-Shahi Salman R, Menon DK, Nicholson TR, Benjamin LA, Carson A, Smith C, Turner MR, Solomon T, Kneen R, Pett SL, Galea I, Thomas RH, Michael BD; CoroNerve Study Group. Neurological and neuropsychiatric complications of COVID-19 in 153 patients: a UK-wide surveillance study. Lancet Psychiatry. 2020;7(10):875–882. https://doi.org/10.1016/S2215-0366(20)30287-X. Erratum in: Lancet Psychiatry. 2020

Pinzon RT, Wijaya VO, Jody AA, Nunsio PN, Buana RB (2022) Persistent neurological manifestations in long COVID-19 syndrome: A systematic review and meta-analysis. J Infect Public Health. 15(8):856–869. https://doi.org/10.1016/j.jiph.2022.06.013

Article  PubMed  PubMed Central  Google Scholar 

Williams LD, Zis P (2023) COVID-19-related burning eye syndrome and burning mouth syndrome: a systematic review and meta-analysis. Pain Ther. 14:1–10. https://doi.org/10.1007/s40122-023-00492-3

Article  Google Scholar 

Oaklander AL, Mills AJ, Kelley M, Toran LS, Smith B, Dalakas MC, Nath A (2022) Peripheral neuropathy evaluations of patients with prolonged long COVID. Neurol Neuroimmunol Neuroinflamm 9(3):e1146. https://doi.org/10.1212/NXI.0000000000001146

Article  PubMed  PubMed Central  Google Scholar 

O’Mahoney LL, Routen A, Gillies C, Ekezie W, Welford A, Zhang A, Karamchandani U, Simms-Williams N, Cassambai S, Ardavani A, Wilkinson TJ, Hawthorne G, Curtis F, Kingsnorth AP, Almaqhawi A, Ward T, Ayoubkhani D, Banerjee A, Calvert M, Shafran R, Stephenson T, Sterne J, Ward H, Evans RA, Zaccardi F, Wright S, Khunti K. The prevalence and long-term health effects of Long Covid among hospitalised and non-hospitalised populations: A systematic review and meta-analysis. EClinicalMedicine. 2022;55:101762. https://doi.org/10.1016/j.eclinm.2022.101762. Erratum in: EClinicalMedicine. 2023;59:101959

Williams LD, Zis P (2023) COVID-19-related neuropathic pain: a systematic review and meta-analysis. J Clin Med 12(4):1672. https://doi.org/10.3390/jcm12041672

Article  CAS  PubMed  PubMed Central  Google Scholar 

Davis HE, McCorkell L, Vogel JM et al (2023) Long COVID: major findings, mechanisms and recommendations. Nat Rev Microbiol 21:133–146. https://doi.org/10.1038/s41579-022-00846-2

Article  CAS  PubMed  PubMed Central  Google Scholar 

Galván Casas C, Català A, Carretero Hernández G, Rodríguez-Jiménez P, Fernández-Nieto D et al (2020) Classification of the cutaneous manifestations of COVID-19: a rapidprospective nationwide consensus study in Spain with 375 cases. Br J Dermatol 183(1):71–77

Article  PubMed  PubMed Central  Google Scholar 

Spudich S, Nath A (2022) Nervous system consequences of COVID-19. Science 375:267–269

Article  CAS  PubMed  Google Scholar 

Hosey MM, Needham DM (2020) Survivorship after COVID-19 ICU stay. Nat Rev Dis Primers 6:60

Article  PubMed  PubMed Central  Google Scholar 

International Association for the Study of Pain (2017) IASP Taxonomy. Pain terms. Neuropathic pain. Updated 2017

Murnion BP (2018) Neuropathic pain: current definition and review of drug treatment. Aust Prescr 41:60–3

Article  PubMed  PubMed Central  Google Scholar 

Joshi D, Gyanpuri V, Pathak A, Chaurasia RN, Mishra VN, Kumar A, Singh VK, Dhiman NR (2022) Neuropathic pain associated with COVID-19: a systematic review of case reports. Curr Pain Headache Rep. 26(8):595–603. https://doi.org/10.1007/s11916-022-01065-3

Article  PubMed  PubMed Central  Google Scholar 

Vaz A, Costa A, Pinto A et al (2021) Complex regional pain syndrome after severe COVID-19 – a case report. Heliyon 7(11):e08462

Article  CAS  PubMed  PubMed Central  Google Scholar 

Branavan B, Indrakumar J (2022) Possible complex regional pain syndrome following SARS-CoV-2 infection: case report. SAGE Open Med Case Rep. https://doi.org/10.1177/2050313X221093111

Article  PubMed  PubMed Central  Google Scholar 

Attal N, Martinez V, Bouhassira D (2021) Potential for increased prevalence of neuropathic pain after the COVID-19 pandemic. Pain Rep. 6(1):e884

Article  PubMed  PubMed Central  Google Scholar 

Malik GR, Wolfe AR, Soriano R, Rydberg L, Wolfe LF, Deshmukh S, Ko JH, Nussbaum RP, Dreyer SD, Jayabalan P, Walter JM, Franz CK (2020) Injury-prone: peripheral nerve injuries associated with prone positioning for COVID-19-related acute respiratory distress syndrome. Br J Anaesth 125:e478–e480

Article  CAS  PubMed  Google Scholar 

Zubair AS, McAlpine LS, Gardin T, Farhadian S, Kuruvilla DE, Spudich S (2020) Neuropathogenesis and neurologic manifestations of the coronaviruses in the age of coronavirus disease 2019: a review. JAMA Neurol 77:1018–1027

Article  PubMed  PubMed Central  Google Scholar 

Campbell JN, Meyer RA (2006) Mechanisms of neuropathic pain. Neuron 52(1):77–92. https://doi.org/10.1016/j.neuron.2006.09.021

Article  CAS  PubMed  PubMed Central  Google Scholar 

Klit H, Finnerup NB, Jensen TS (2009) Central post-stroke pain: clinical characteristics, pathophysiology, and management. Lancet Neurol 8:857–68

Article  PubMed  Google Scholar 

AlKetbi R, AlNuaimi D, AlMulla M, AlTalai N, Samir M, Kumar N, AlBastaki U (2020) Acute myelitis as a neurological complication of Covid-19: a case report and MRI findings. Radiol Case Rep 15:1591–1595

Article  PubMed  PubMed Central  Google Scholar 

Valiuddin H, Skwirsk B, Paz-Arabo P (2020) Acute transverse myelitis associated with SARS-CoV-2: a Case-Report. Brain Behav Immun Health 5:100091

Article  PubMed  PubMed Central  Google Scholar 

Chow CCN, Magnussen J, Ip J, Su Y (2020) Acute transverse myelitis in COVID-19 infection. BMJ Case Rep 13:e236720

Article  PubMed  PubMed Central  Google Scholar 

Sarma D, Bilello LA (2020) A case report of acute transverse myelitis following novel coronavirus infection. Clin Pract Cases Emerg Med 4(3):321–323. https://doi.org/10.5811/cpcem.2020.5.47937.

Article  PubMed  PubMed Central  Google Scholar 

Zhao K, Huang J, Dai D, Feng Y, Liu L, Nie S (2020) Acute myelitis after SARS-cov-2 infection: a case report. Medrxiv. https://www.medrxiv.org/content/https://doi.org/10.1101/2020.03.16.20035105v1.full.pdf

Paliwal VK, Garg RK, Gupta A, Tejan N (2020) Neuromuscular presentations in patients with COVID-19. Neurol Sci 41:3039–3056

Article  PubMed  PubMed Central  Google Scholar 

Martinez V, Fletcher D, Martin F, Orlikowski D, Sharshar T, Chauvin M, Bouhassira D, Attal N (2010) Small fibre impairment predicts neuropathic pain in Guillain-Barré syndrome. PAIN 151:53–60

Article  PubMed  Google Scholar 

Scheidl E, Canseco DD, Hadji-Naumov A, Bereznai B (2020) Guillain-Barré syndrome during SARS-CoV-2 pandemic: a case report and review of recent literature. J Peripher Nerv Syst 25:204–7

Article  CAS  PubMed  Google Scholar 

Aksan F, Nelson EA, Swedish KA (2020) A COVID-19 patient with intense burning pain. J Neurovirol 26:800–801. https://doi.org/10.1007/s13365-020-00887-4

Article  CAS  PubMed  PubMed Central  Google Scholar 

McWilliam M, Samuel M (2021) Alkufri FH Neuropathic pain post-COVID-19: a case report. BMJ Case Reports CP 14:e243459

Article  Google Scholar 

Tran VT, Porcher R, Pane I, Ravaud P (2022) Course of post COVID-19 disease symptoms over time in the ComPaRe long COVID prospective e-cohort. Nat Commun 13(1):1812. https://doi.org/10.1038/s41467-022-29513-z

Article  CAS  PubMed  PubMed Central 

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