Zilli Vieira CL, Alvares D, Blomberg A, Schwartz J, Coull B, Huang S, et al. Geomagnetic disturbances driven by solar activity enhance total and cardiovascular mortality risk in 263 U.S. cities. Environ Health. 2019;18:83.

Article  PubMed  PubMed Central  Google Scholar 

Zilli Vieira CL, Link MS, Garshick E, Peralta AA, Luttmann-Gibson H, Laden F, et al. Solar and geomagnetic activity enhance the effects of air pollutants on atrial fibrillation. Europace. 2022;24:713–20.

Article  PubMed  Google Scholar 

Vieira CLZ, Janot-Pacheco E, Lage C, Pacini A, Koutrakis P, Cury PR, et al. Long-term association between the intensity of cosmic rays and mortality rates in the city of Sao Paulo. Environ Res Lett. 2018;13:024009.

Article  Google Scholar 

Scheibler C, Toprani SM, Mordukhovich I, Schaefer M, Staffa S, Nagel ZD, et al. Cancer risks from cosmic radiation exposure in flight: A review. Front Public Health. 2022;10:947068.

Article  PubMed  PubMed Central  Google Scholar 

Usoskin IG, Desorgher L, Velinov P, Storini M, Flückiger EO, Bütikofer R, et al. Ionization of the earth’s atmosphere by solar and galactic cosmic rays. Acta Geophysica. 2008;57:88–101.

Article  Google Scholar 

Forbush SE. On the effects in cosmic-ray intensity observed during the recent magnetic storm. Phys Rev. 1937;51:1108–9.

Article  Google Scholar 

Di Trolio R, Di Lorenzo G, Fumo B, Ascierto PA. Cosmic radiation and cancer: is there a link? Future Oncol. 2015;11:1123–35.

Article  PubMed  Google Scholar 

Mazzei-Abba A, Folly CL, Kreis C, Ammann RA, Adam C, Brack E, et al. External background ionizing radiation and childhood cancer: Update of a nationwide cohort analysis. J Environ Radioact. 2021;238-239:106734.

Article  CAS  PubMed  Google Scholar 

Gilchrest BA, Eller MS, Geller AC, Yaar M. The pathogenesis of melanoma induced by ultraviolet radiation. N. Engl J Med. 1999;340:1341–8.

Article  CAS  PubMed  Google Scholar 

Kim Y, He YY. Ultraviolet radiation-induced non-melanoma skin cancer: Regulation of DNA damage repair and inflammation. Genes Dis. 2014;1:188–98.

Article  PubMed  PubMed Central  Google Scholar 

Fleischer AB Jr., Fleischer SE. Solar radiation and the incidence and mortality of leading invasive cancers in the United States. Dermatoendocrinol. 2016;8:e1162366.

Article  PubMed  PubMed Central  Google Scholar 

Barnes RP, Fouquerel E, Opresko PL. The impact of oxidative DNA damage and stress on telomere homeostasis. Mech Ageing Dev. 2019;177:37–45.

Article  CAS  PubMed  Google Scholar 

Hewitt G, Jurk D, Marques FD, Correia-Melo C, Hardy T, Gackowska A, et al. Telomeres are favoured targets of a persistent DNA damage response in ageing and stress-induced senescence. Nat Commun. 2012;3:708.

Article  PubMed  Google Scholar 

Vaiserman A, Krasnienkov D. Telomere length as a marker of biological age: state-of-the-art, open issues, and future perspectives. Front Genet. 2020;11:630186.

Article  CAS  PubMed  Google Scholar 

Stone RC, Horvath K, Kark JD, Susser E, Tishkoff SA, Aviv A. Telomere length and the cancer-atherosclerosis trade-off. PLoS Genet. 2016;12:e1006144.

Article  PubMed  PubMed Central  Google Scholar 

de Lange T. How telomeres solve the end-protection problem. Science. 2009;326:948–52.

Article  PubMed  PubMed Central  Google Scholar 

Zhang J, Rane G, Dai X, Shanmugam MK, Arfuso F, Samy RP, et al. Ageing and the telomere connection: An intimate relationship with inflammation. Ageing Res Rev. 2016;25:55–69.

Article  CAS  PubMed  Google Scholar 

von Zglinicki T. Oxidative stress shortens telomeres. Trends Biochemical Sci. 2002;27:339–44.

Article  Google Scholar 

Morla M, Busquets X, Pons J, Sauleda J, MacNee W, Agusti AG. Telomere shortening in smokers with and without COPD. Eur Respir J. 2006;27:525–8.

Article  CAS  PubMed  Google Scholar 

Kim S, Parks CG, DeRoo LA, Chen H, Taylor JA, Cawthon RM, et al. Obesity and weight gain in adulthood and telomere length. Cancer Epidemiol Biomark Prev. 2009;18:816–20.

Article  CAS  Google Scholar 

Haycock PC, Heydon EE, Kaptoge S, Butterworth AS, Thompson A, Willeit P. Leucocyte telomere length and risk of cardiovascular disease: systematic review and meta-analysis. BMJ. 2014;349:g4227.

Article  PubMed  PubMed Central  Google Scholar 

Miri M, Nazarzadeh M, Alahabadi A, Ehrampoush MH, Rad A, Lotfi MH, et al. Air pollution and telomere length in adults: A systematic review and meta-analysis of observational studies. Environ Pollut. 2019;244:636–47.

Article  CAS  PubMed  Google Scholar 

McCracken J, Baccarelli A, Hoxha M, Dioni L, Melly S, Coull B, et al. Annual ambient black carbon associated with shorter telomeres in elderly men: Veterans Affairs Normative Aging Study. Environ Health Perspect. 2010;118:1564–70.

Article  PubMed  PubMed Central  Google Scholar 

Shim G, Ricoul M, Hempel WM, Azzam EI, Sabatier L. Crosstalk between telomere maintenance and radiation effects: A key player in the process of radiation-induced carcinogenesis. Mutat Res Rev Mutat Res. 2014;760:1–17.

Article  CAS  Google Scholar 

Li P, Hou M, Lou F, Bjorkholm M, Xu D. Telomere dysfunction induced by chemotherapeutic agents and radiation in normal human cells. Int J Biochem Cell Biol. 2012;44:1531–40.

Article  CAS  PubMed  Google Scholar 

Berardinelli F, Antoccia A, Cherubini R, De Nadal V, Gerardi S, Tanzarella C, et al. Telomere alterations and genomic instability in long-term cultures of normal human fibroblasts irradiated with X rays and protons. Radiat Prot Dosim. 2011;143:274–8.

Article  CAS  Google Scholar 

Berardinelli F, Antoccia A, Buonsante R, Gerardi S, Cherubini R, et al. The role of telomere length modulation in delayed chromosome instability induced by ionizing radiation in human primary fibroblasts. Environ Mol Mutagen. 2013;54:172–9.

Article  CAS  PubMed  Google Scholar 

Moller P, Wils RS, Jensen DM, Andersen MHG, Roursgaard M. Telomere dynamics and cellular senescence: an emerging field in environmental and occupational toxicology. Crit Rev Toxicol. 2018;48:761–88.

Article  PubMed  Google Scholar 

Garrett-Bakelman FE, Darshi M, Green SJ, Gur RC, Lin L, Macias BR, et al. The NASA Twins Study: A multidimensional analysis of a year-long human spaceflight. Science. 2019;364:eaau8650.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Luxton JJ, McKenna MJ, Lewis A, Taylor LE, George KA, Dixit SM, et al. Telomere length dynamics and DNA damage responses associated with long-duration spaceflight. Cell Rep. 2020;33:108457.

Article  CAS  PubMed  Google Scholar 

Luxton JJ, McKenna MJ, Taylor LE, George KA, Zwart SR, Crucian BE, et al. Temporal telomere and DNA damage responses in the space radiation environment. Cell Rep. 2020;33:108435.

Article  CAS  PubMed  Google Scholar 

Das B, Saini D, Seshadri M. Telomere length in human adults and high level natural background radiation. PLoS One. 2009;4:e8440.

Article  PubMed  PubMed Central  Google Scholar 

Chougaonkar MP, Eappen KP, Ramachandran TV, Shetty PG, Mayya YS, Sadasivan S, et al. Profiles of doses to the population living in the high background radiation areas in Kerala, India. J Environ Radioactivity. 2004;71:275–97.

Article  CAS  Google Scholar 

Cucinotta FA, Kim MH, Willingham V, George KA. Physical and biological organ dosimetry analysis for international space station astronauts. Radiat Res. 2008;170:127–38.

Article  CAS  PubMed  Google Scholar 

Scherthan H, Sotnik N, Peper M, Schrock G, Azizova T, Abend M. Telomere Length in Aged Mayak PA Nuclear Workers Chronically Exposed to Internal Alpha and External Gamma Radiation. Radiat Res. 2016;185:658–67.

Article  CAS  PubMed  Google Scholar 

Andreassi MG, Piccaluga E, Gargani L, Sabatino L, Borghini A, Faita F, et al. Subclinical carotid atherosclerosis and early vascular aging from long-term low-dose ionizing radiation exposure: a genetic, telomere, and vascular ultrasound study in cardiac catheterization laboratory staff. JACC Cardiovasc Interv 2015;8:616–27.

Article  PubMed  Google Scholar 

Usoskin IG, Kovaltsov GA. Cosmic ray induced ionization in the atmosphere: Full modeling and practical applications. J Geophys Res. 2006;111:D21206.

Google Scholar 

Zilli Vieira CL, Koutrakis P. The impact of solar activity on ambient ultrafine particle concentrations: An analysis based on 19-year measurements in Boston, USA. Environ Res. 2021;201:111532.

Article  CAS  PubMed  Google Scholar 

University of Delaware Bartol Research Institute neutron monitor program. 2021. https://neutronm.bartol.udel.edu/ Accessed 30 June 2022.

Cawthon RM. Telomere measurement by quantitative PCR. Nucleic Acids Res. 2002;30:e47.

Article