Investigation of non-invasive focused ultrasound efficacy on depressive-like behavior in hemiparkinsonian rats

Aaronson ST, Carpenter LL, Conway CR, Reimherr FW, Lisanby SH, Schwartz TL, Moreno FA, Dunner DL, Lesem MD, Thompson PM, Husain M, Vine CJ, Banov MD, Bernstein LP, Lehman RB, Brannon GE, Keepers GA, O’Reardon JP, Rudolph RL, Bunker M (2013) Vagus nerve stimulation therapy randomized to different amounts of electrical charge for treatment-resistant depression: acute and chronic effects. Brain Stimul 64:631–640. https://doi.org/10.1016/j.brs.2012.09.013

Article  Google Scholar 

Aarsland D, Påhlhagen S, Ballard CG, Ehrt U, Svenningsson P (2011) Depression in Parkinson disease-epidemiology, mechanisms and management. Nat Rev Neurol 81:35–47. https://doi.org/10.1038/nrneurol.2011.189

Article  CAS  Google Scholar 

Akhtar K, Hirschstein Z, Stefanelli A, Iannilli E, Srinivasan A, Barenboim L, Balkaya M, Cunha A, Audil A, Kochman EM, Chua F, Ravi M, Mikkilineni S, Watkins H, O’Connor W Jr, Fan Y, Cotero V, Ashe J, Puleo C, Kao TJ, Shin DS (2021) Non-invasive peripheral focused ultrasound neuromodulation of the celiac plexus ameliorates symptoms in a rat model of inflammatory bowel disease. Exp Physiol 1064:1038–1060. https://doi.org/10.1113/ep088848

Article  Google Scholar 

American Psychiatry Association (2013) Diagnostic and Statistical Manual of Mental Disorders. Washington, DC

Antila H, Ryazantseva M, Popova D, Sipilä P, Guirado R, Kohtala S, Yalcin I, Lindholm J, Vesa L, Sato V, Cordeira J, Autio H, Kislin M, Rios M, Joca S, Casarotto P, Khiroug L, Lauri S, Taira T, Castrén E, Rantamäki T (2017) Isoflurane produces antidepressant effects and induces Trkb signaling in rodents. Sci Rep 71:7811. https://doi.org/10.1038/s41598-017-08166-9

Article  CAS  Google Scholar 

Baden JM, Kundomal YR, Mazze RI, Kosek JC (1988) Carcinogen bioassay of isoflurane in mice. Anesthesiology 695:750–753. https://doi.org/10.1097/00000542-198811000-00018

Article  Google Scholar 

Barone P, Scarzella L, Marconi R, Antonini A, Morgante L, Bracco F, Zappia M, Musch B (2006) Pramipexole versus sertraline in the treatment of depression in Parkinson’s disease: a national multicenter parallel-group randomized study. J Neurol 2535:601–607. https://doi.org/10.1007/s00415-006-0067-5

Article  Google Scholar 

Barone P, Poewe W, Albrecht S, Debieuvre C, Massey D, Rascol O, Tolosa E, Weintraub D (2010) Pramipexole for the treatment of depressive symptoms in patients with Parkinson’s disease: a randomised, double-blind, placebo-controlled trial. lancet Neurol 96:573–580. https://doi.org/10.1016/s1474-4422(10)70106-x

Article  Google Scholar 

Bonato JM, Bassani TB, Milani H, Vital M, de Oliveira RMW (2018) Pioglitazone reduces mortality, prevents depressive-like behavior, and impacts hippocampal neurogenesis in the 6-Ohda model of Parkinson’s disease in rats. Exp Neurol 300:188–200. https://doi.org/10.1016/j.expneurol.2017.11.009

Article  CAS  PubMed  Google Scholar 

Bonaz B, Sinniger V, Pellissier S (2016) Anti-inflammatory properties of the vagus nerve: potential therapeutic implications of vagus nerve stimulation. J Physiol 59420:5781–5790. https://doi.org/10.1113/jp271539

Article  Google Scholar 

Braak H, Rüb U, Gai WP, Del Tredici K (2003) Idiopathic Parkinson’s disease: possible routes by which vulnerable neuronal types may be subject to neuroinvasion by an unknown pathogen. J Neural Transm (vienna) 1105:517–536. https://doi.org/10.1007/s00702-002-0808-2

Article  Google Scholar 

Brougher J, Aziz U, Adari N, Chaturvedi M, Jules A, Shah I, Syed S, Thorn CA (2021) Self-administration of right vagus nerve stimulation activates midbrain dopaminergic nuclei. Front Neurosci 15:782786. https://doi.org/10.3389/fnins.2021.782786

Article  PubMed  PubMed Central  Google Scholar 

Brunello N, Mendlewicz J, Kasper S, Leonard B, Montgomery S, Nelson J, Paykel E, Versiani M, Racagni G (2002) The role of noradrenaline and selective noradrenaline reuptake inhibition in depression. Eur Neuropsychopharmacol 125:461–475. https://doi.org/10.1016/s0924-977x(02)00057-3

Article  Google Scholar 

Carpenter LL, Moreno FA, Kling MA, Anderson GM, Regenold WT, Labiner DM, Price LH (2004) Effect of vagus nerve stimulation on cerebrospinal fluid monoamine metabolites, norepinephrine, and gamma-aminobutyric acid concentrations in depressed patients. Biol Psychiatry 566:418–426. https://doi.org/10.1016/j.biopsych.2004.06.025

Article  CAS  Google Scholar 

Costa A, Peppe A, Carlesimo GA, Pasqualetti P, Caltagirone C (2006) Major and minor depression in parkinson’s disease: a neuropsychological investigation. Eur J Neurol 139:972–980. https://doi.org/10.1111/j.1468-1331.2006.01406.x

Article  Google Scholar 

Cotero V, Fan Y, Tsaava T, Kressel AM, Hancu I, Fitzgerald P, Wallace K, Kaanumalle S, Graf J, Rigby W, Kao TJ, Roberts J, Bhushan C, Joel S, Coleman TR, Zanos S, Tracey KJ, Ashe J, Chavan SS, Puleo C (2019) Noninvasive sub-organ ultrasound stimulation for targeted neuromodulation. Nat Commun 101:952. https://doi.org/10.1038/s41467-019-08750-9

Article  CAS  Google Scholar 

Dallé E, Daniels WMU, Mabandla MV (2020) Long-term treatment with fluvoxamine decreases nonmotor symptoms and dopamine depletion in a postnatal stress rat model of Parkinson’s disease. Oxid Med Cell Longev 2020:1941480. https://doi.org/10.1155/2020/1941480

Article  CAS  PubMed  PubMed Central  Google Scholar 

Devos D, Dujardin K, Poirot I, Moreau C, Cottencin O, Thomas P, Destée A, Bordet R, Defebvre L (2008) Comparison of desipramine and citalopram treatments for depression in Parkinson’s disease: a double-blind, randomized, placebo-controlled study. Mov Disord 236:850–857. https://doi.org/10.1002/mds.21966

Article  Google Scholar 

Diener HC, Goadsby PJ, Ashina M, Al-Karagholi MA, Sinclair A, Mitsikostas D, Magis D, Pozo-Rosich P, Irimia Sieira P, Làinez MJ, Gaul C, Silver N, Hoffmann J, Marin J, Liebler E, Ferrari MD (2019) Non-invasive vagus nerve stimulation (Nvns) for the preventive treatment of episodic migraine: the multicentre, double-blind, randomised, sham-controlled premium trial. Cephalalgia 3912:1475–1487. https://doi.org/10.1177/0333102419876920

Article  Google Scholar 

Dorr AE, Debonnel G (2006) Effect of vagus nerve stimulation on serotonergic and noradrenergic transmission. J Pharmacol Exp Ther 3182:890–898. https://doi.org/10.1124/jpet.106.104166

Article  CAS  Google Scholar 

Farrand AQ, Helke KL, Gregory RA, Gooz M, Hinson VK, Boger HA (2017) Vagus nerve stimulation improves locomotion and neuronal populations in a model of Parkinson’s disease. Brain Stimul 106:1045–1054. https://doi.org/10.1016/j.brs.2017.08.008

Article  Google Scholar 

Feng XJ, Huang YT, Huang YZ, Kuo CW, Peng CW, Rotenberg A, Juan CH, Pei YC, Chen YH, Chen KY, Chiang YH, Liu HH, Wu JX, Hsieh TH (2020) Early transcranial direct current stimulation treatment exerts neuroprotective effects on 6-Ohda-induced Parkinsonism in rats. Brain Stimul 133:655–663. https://doi.org/10.1016/j.brs.2020.02.002

Article  Google Scholar 

Frosini D, Unti E, Guidoccio F, Del Gamba C, Puccini G, Volterrani D, Bonuccelli U, Ceravolo R (2015) Mesolimbic dopaminergic dysfunction in Parkinson’s disease depression: evidence from a 123i-Fp-Cit spect investigation. J Neural Transm (vienna) 1228:1143–1147. https://doi.org/10.1007/s00702-015-1370-z

Article  CAS  Google Scholar 

Furlanetti LL, Coenen VA, Aranda IA, Döbrössy MD (2015) Chronic deep brain stimulation of the medial forebrain bundle reverses depressive-like behavior in a Hemiparkinsonian rodent model. Exp Brain Res 23311:3073–3085. https://doi.org/10.1007/s00221-015-4375-9

Article  Google Scholar 

García-Toro M, Segura C, González A, Perelló J, Valdivia J, Salazar R, Tarancón G, Campoamor F, Salva J, De La Fuente L, Romera M (2001) Inefficacy of burst-suppression anesthesia in medication-resistant major depression: a controlled trial. J Ect 174:284–288. https://doi.org/10.1097/00124509-200112000-00009

Article  Google Scholar 

Gencler OS, Oztekin N, Oztekin MF (2022) Comparison of pramipexole versus ropinirole in the treatment of Parkinson’s disease. Ideggyogy Sz 751–02:39–49. https://doi.org/10.18071/isz.75.0039

Article  Google Scholar 

Greenberg LB, Gage J, Vitkun S, Fink M (1987) Isoflurane anesthesia therapy: a replacement for ect in depressive disorders? Convuls Ther 34:269–277

Google Scholar 

Groves DA, Bowman EM, Brown VJ (2005) Recordings from the rat locus coeruleus during acute vagal nerve stimulation in the anaesthetised rat. Neurosci Lett 3793:174–179. https://doi.org/10.1016/j.neulet.2004.12.055

Article  CAS  Google Scholar 

Hsueh SC, Chen KY, Lai JH, Wu CC, Yu YW, Luo Y, Hsieh TH, Chiang YH (2018) Voluntary physical exercise improves subsequent motor and cognitive impairments in a rat model of Parkinson’s disease. Int J Mol Sci. https://doi.org/10.3390/ijms19020508

Article  PubMed  PubMed Central  Google Scholar 

Jiang Y, Cao Z, Ma H, Wang G, Wang X, Wang Z, Yang Y, Zhao H, Liu G, Li L, Feng T (2018) Auricular vagus nerve stimulation exerts antiinflammatory effects and immune regulatory function in a 6-Ohda model of Parkinson’s disease. Neurochem Res 4311:2155–2164. https://doi.org/10.1007/s11064-018-2639-z

Article  CAS  Google Scholar 

Kamińska K, Lenda T, Konieczny J, Czarnecka A, Lorenc-Koci E (2017) Depressive-like neurochemical and behavioral markers of Parkinson’s disease after 6-Ohda administered unilaterally to the rat medial forebrain bundle. Pharmacol Rep 695:985–994. https://doi.org/10.1016/j.pharep.2017.05.016

Article  CAS  Google Scholar 

Krahl SE, Senanayake SS, Pekary AE, Sattin A (2004) Vagus nerve stimulation (Vns) is effective in a rat model of antidepressant action. J Psychiatr Res 383:237–240. https://doi.org/10.1016/j.jpsychires.2003.11.005

Article  Google Scholar 

Kumari N, Agrawal S, Kumari R, Sharma D, Luthra PM (2018) Neuroprotective effect of idpu (1-(7-imino-3-propyl-2,3-dihydrothiazolo [4,5-D]pyrimidin-6(7h)-Yl)urea) in 6-Ohda induced rodent model of Hemiparkinson’s disease. Neurosci Lett 675:74–82. https://doi.org/10.1016/j.neulet.2018.03.040

Article  CAS  PubMed  Google Scholar 

Leentjens AF, Vreeling FW, Luijckx GJ, Verhey FR (2003) Ssris in the treatment of depression in Parkinson’s disease. Int J Geriatr Psychiatry 186:552–554. https://doi.org/10.1002/gps.865

Article  Google Scholar 

Lemke MR, Fuchs G, Gemende I, Herting B, Oehlwein C, Reichmann H, Rieke J, Volkmann J (2004) Depression and Parkinson’s disease. J Neurol. https://doi.org/10.1007/s00415-004-1606-6

Article  Google Scholar 

Lemke MR, Brecht HM, Koester J, Kraus PH, Reichmann H (2005) Anhedonia, depression, and motor functioning in Parkinson’s disease during treatment with pramipexole. J Neuropsychiatry Clin Neurosci 172:214–220. https://doi.org/10.1176/jnp.17.2.214

Article  Google Scholar 

Li S, Wang Y, Gao G, Guo X, Zhang Y, Zhang Z, Wang Y, Zhang J, Wang J, Li L, Yang Y, Rong P (2020) Transcutaneous auricular vagus nerve stimulation at 20 Hz improves depression-like behaviors and down-regulates the hyperactivity of Hpa axis in chronic unpredictable mild stress model rats. Front Neurosci 14:680. https://doi.org/10.3389/fnins.2020.00680

Article  PubMed  PubMed Central  Google Scholar 

Lin YH, Liu AH, Xu Y, Tie L, Yu HM, Li XJ (2005) Effect of chronic unpredictable mild stress on brain-pancreas relative protein in rat brain and pancreas. Behav Brain Res 1651:63–71. https://doi.org/10.1016/j.bbr.2005.06.034

Comments (0)

No login
gif