John A, Reddy PH. Synaptic basis of Alzheimer’s disease: focus on synaptic amyloid beta, P-tau and mitochondria. Ageing Res Rev. 2021;65:101208.

Article  CAS  PubMed  Google Scholar 

Scheff SW, Price DA, Schmitt FA, Mufson EJ. Hippocampal synaptic loss in early Alzheimer’s disease and mild cognitive impairment. Neurobiol Aging. 2006;27:1372–84.

Article  CAS  PubMed  Google Scholar 

Styr B, Slutsky I. Imbalance between firing homeostasis and synaptic plasticity drives early-phase Alzheimer’s disease. Nat Neurosci. 2018;21:463–73.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Forner S, Baglietto-Vargas D, Martini AC, Trujillo-Estrada L, LaFerla FM. Synaptic impairment in Alzheimer’s disease: a dysregulated symphony. Trends Neurosci. 2017;40:347–57.

Article  CAS  PubMed  Google Scholar 

Scheff SW, DeKosky ST, Price DA. Quantitative assessment of cortical synaptic density in Alzheimer’s disease. Neurobiol Aging. 1990;11:29–37.

Article  CAS  PubMed  Google Scholar 

Campbell RR, Wood MA. How the epigenome integrates information and reshapes the synapse. Nat Rev Neurosci. 2019;20:133–47.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kim S, Kaang BK. Epigenetic regulation and chromatin remodeling in learning and memory. Exp Mol Med. 2017;49:e281.

Article  PubMed  PubMed Central  Google Scholar 

Wang J, Hodes GE, Zhang H, Zhang S, Zhao W, Golden SA, et al. Epigenetic modulation of inflammation and synaptic plasticity promotes resilience against stress in mice. Nat Commun. 2018;9:477.

Article  PubMed  PubMed Central  Google Scholar 

Bustos FJ, Ampuero E, Jury N, Aguilar R, Falahi F, Toledo J, et al. Epigenetic editing of the Dlg4/PSD95 gene improves cognition in aged and Alzheimer’s disease mice. Brain. 2017;140:3252–68.

Article  PubMed  PubMed Central  Google Scholar 

Halder R, Hennion M, Vidal RO, Shomroni O, Rahman RU, Rajput A, et al. DNA methylation changes in plasticity genes accompany the formation and maintenance of memory. Nat Neurosci. 2016;19:102–10.

Article  CAS  PubMed  Google Scholar 

Kennedy AJ, Rahn EJ, Paulukaitis BS, Savell KE, Kordasiewicz HB, Wang J, et al. Tcf4 regulates synaptic plasticity, DNA methylation, and memory function. Cell Rep. 2016;16:2666–85.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Peixoto L, Abel T. The role of histone acetylation in memory formation and cognitive impairments. Neuropsychopharmacology. 2013;38:62–76.

Article  CAS  PubMed  Google Scholar 

Guan JS, Haggarty SJ, Giacometti E, Dannenberg JH, Joseph N, Gao J, et al. HDAC2 negatively regulates memory formation and synaptic plasticity. Nature. 2009;459:55–60.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Penney J, Tsai LH. Histone deacetylases in memory and cognition. Sci Signal. 2014;7:re12.

Article  PubMed  Google Scholar 

Li X, Zhang J, Li D, He C, He K, Xue T, et al. Astrocytic ApoE reprograms neuronal cholesterol metabolism and histone-acetylation-mediated memory. Neuron. 2021;109:957–70.e958.

Article  CAS  PubMed  Google Scholar 

Sando R 3rd, Gounko N, Pieraut S, Liao L, Yates J 3rd, Maximov A. HDAC4 governs a transcriptional program essential for synaptic plasticity and memory. Cell. 2012;151:821–34.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wheeler PG, Huang D, Dai Z. Haploinsufficiency of HDAC4 does not cause intellectual disability in all affected individuals. Am J Med Genet A. 2014;164a:1826–9.

Article  PubMed  Google Scholar 

Williams SR, Aldred MA, Der Kaloustian VM, Halal F, Gowans G, McLeod DR, et al. Haploinsufficiency of HDAC4 causes brachydactyly mental retardation syndrome, with brachydactyly type E, developmental delays, and behavioral problems. Am J Hum Genet. 2010;87:219–28.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Govindarajan N, Rao P, Burkhardt S, Sananbenesi F, Schlüter OM, Bradke F, et al. Reducing HDAC6 ameliorates cognitive deficits in a mouse model for Alzheimer’s disease. EMBO Mol Med. 2013;5:52–63.

Article  CAS  PubMed  Google Scholar 

Wagner FF, Zhang YL, Fass DM, Joseph N, Gale JP, Weïwer M, et al. Kinetically selective inhibitors of histone deacetylase 2 (HDAC2) as cognition enhancers. Chem Sci. 2015;6:804–15.

Article  CAS  PubMed  Google Scholar 

Francis YI, Fà M, Ashraf H, Zhang H, Staniszewski A, Latchman DS, et al. Dysregulation of histone acetylation in the APP/PS1 mouse model of Alzheimer’s disease. J Alzheimers Dis. 2009;18:131–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang J, Liu Q. Age- and disease-related memory decline: epigenetic biomarker and treatment. Sci Bull (Beijing). 2023;68:1719–21.

Article  PubMed  Google Scholar 

Nishimori S, Wein MN, Kronenberg HM. PTHrP targets salt-inducible kinases, HDAC4 and HDAC5, to repress chondrocyte hypertrophy in the growth plate. Bone. 2021;142:115709.

Article  CAS  PubMed  Google Scholar 

Shi F, de Fatima Silva F, Liu D, Patel HU, Xu J, Zhang W, et al. Salt-inducible kinase inhibition promotes the adipocyte thermogenic program and adipose tissue browning. Mol Metab. 2023;74:101753.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang B, Moya N, Niessen S, Hoover H, Mihaylova MM, Shaw RJ, et al. A hormone-dependent module regulating energy balance. Cell. 2011;145:596–606.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhou R, Wang G, Li Q, Meng F, Liu C, Gan R, et al. A signalling pathway for transcriptional regulation of sleep amount in mice. Nature. 2022;612:519–27.

Article  CAS  PubMed  Google Scholar 

Kim SJ, Hotta-Hirashima N, Asano F, Kitazono T, Iwasaki K, Nakata S, et al. Kinase signalling in excitatory neurons regulates sleep quantity and depth. Nature. 2022;612:512–8.

Article  CAS  PubMed  Google Scholar 

Asano F, Kim SJ, Fujiyama T, Miyoshi C, Hotta-Hirashima N, Asama N, et al. SIK3-HDAC4 in the suprachiasmatic nucleus regulates the timing of arousal at the dark onset and circadian period in mice. Proc Natl Acad Sci USA. 2023;120:e2218209120.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Herring BE, Nicoll RA. Long-term potentiation: from CaMKII to AMPA receptor trafficking. Annu Rev Physiol. 2016;78:351–65.

Article  CAS  PubMed  Google Scholar 

Derkach VA, Oh MC, Guire ES, Soderling TR. Regulatory mechanisms of AMPA receptors in synaptic plasticity. Nat Rev Neurosci. 2007;8:101–13.

Article  CAS  PubMed  Google Scholar 

Okuyama T, Kitamura T, Roy DS, Itohara S, Tonegawa S. Ventral CA1 neurons store social memory. Science. 2016;353:1536–41.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lahm A, Paolini C, Pallaoro M, Nardi MC, Jones P, Neddermann P, et al. Unraveling the hidden catalytic activity of vertebrate class IIa histone deacetylases. Proc Natl Acad Sci USA. 2007;104:17335–40.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xu J, Zhou R, Wang G, Guo Y, Gao X, Zhou S, et al. Regulation of sleep quantity and intensity by long and short isoforms of SLEEPY kinase. Sleep. 2022;45:zsac198.

Ponnusamy L, Kothandan G, Manoharan R. Berberine and Emodin abrogates breast cancer growth and facilitates apoptosis through inactivation of SIK3-induced mTOR and Akt signaling pathway. Biochim Biophys Acta Mol Basis Dis. 2020;1866:165897.

Article  CAS  PubMed  Google Scholar 

Yan P, Wang Y, Meng X, Yang H, Liu Z, Qian J, et al. Whole exome sequencing of ulcerative colitis-associated colorectal cancer based on novel somatic mutations identified in Chinese patients. Inflamm Bowel Dis. 2019;25:1293–301.

Article  PubMed  Google Scholar 

Lee M, Sorn SR, Lee Y, Kang I. Salt induces adipogenesis/lipogenesis and inflammatory adipocytokines secretion in adipocytes. Int J Mol Sci. 2019;20:160.

Dai XM, Zhang YH, Lin XH, Huang XX, Zhang Y, Xue CR, et al. SIK2 represses AKT/GSK3β/β-catenin signaling and suppresses gastric cancer by inhibiting autophagic degradation of protein phosphatases. Mol Oncol. 2021;15:228–45.

Article  CAS  PubMed  Google Scholar