Feigin VL, Nichols E, Alam T, Bannick MS, Beghi E, Blake N, et al. Global, regional, and national burden of neurological disorders, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet Neurol. 2019;18(5):459–80.
Mondello S, Hayes RL. Biomarkers. Handbook Clin Neurol. 2015;127:245–65.
Pasi M, Cordonnier C. Clinical relevance of cerebral small vessel diseases. Stroke. 2020;51(1):47–53. https://doi.org/10.1161/strokeaha.119.024148.
Pantoni L, Gorelick P. Advances in vascular cognitive impairment 2010. Stroke. 2011;42:291–3.
Hilal S, Mok V, Youn YC, Wong A, Ikram MK, Chen CL-H. Prevalence, risk factors and consequences of cerebral small vessel diseases: data from three Asian countries. J Neurol Neurosurg Psychiatry. 2017;88(8):669–74.
Lewis BP, Burge CB, Bartel DP. Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell. 2005;120(1):15–20.
Article CAS PubMed Google Scholar
Rao P, Benito E, Fischer A. MicroRNAs as biomarkers for CNS disease. Front Mol Neurosci. 2013;6:39.
Article CAS PubMed PubMed Central Google Scholar
Prabhakar P, Chandra SR, Christopher R. Circulating microRNAs as potential biomarkers for the identification of vascular dementia due to cerebral small vessel disease. Age Ageing. 2017;46:861–4.
Farag S, Kenawy FF, Shokri HM, Zakaria M, Aref H, Fahmi N, et al. The clinical characteristics of patients with pre-existing leukoaraiosis compared to those without leukoaraiosis in acute ischemic stroke. J Stroke Cerebrovasc Dis. 2021;30(9): 105956.
Rahman TT, El Gaafary MM. Montreal Cognitive Assessment Arabic version: reliability and validity prevalence of mild cognitive impairment among elderly attending geriatric clubs in Cairo. Geriatr Gerontol Int. 2009;9(1):54–61.
Wolf SL, Catlin PA, Gage K, Gurucharri K, Robertson R, Stephen K. Establishing the reliability and validity of measurements of walking time using the Emory functional ambulation profile. Phys Ther. 1999;79(12):1122–33.
Article CAS PubMed Google Scholar
Berg K. Measuring balance in the elderly: preliminary development of an instrument. Physiother Can. 1989;41(6):304–11.
Abdel-Khalek AM. Internal consistency of an Arabic adaptation of the Beck Depression Inventory in four Arab countries. Psychol Rep. 1998;82(1):264–6.
Hashim H, Avery K, et al. The Arabic ICIQ-UI SF: An alternative language version of the English ICIQ-UI SF. Neurourol Urodyn. 2006;25(3):277–82.
Fazekas F, Kleinert R, Offenbacher H, et al. Pathologic correlates of incidental MRI white matter signal hyperintensities. Neurology. 1993;43:1683–9.
Article CAS PubMed Google Scholar
Staals J, Makin SD, Doubal FN, Dennis MS, Wardlaw JM. Stroke subtype, vascular risk factors, and total MRI brain small-vessel disease burden. Neurology. 2014;83(14):1228–34.
Article PubMed Central Google Scholar
Pasquier F, Leys D, Weerts JG, et al. Inter- and intraobserver reproducibility of cerebral atrophy assessment on MRI scans with hemispheric infarcts. Eur Neurol. 1997;36(5):268–72.
Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods. 2001;25(4):402–8.
Article CAS PubMed Google Scholar
Leary MC, Saver JL. Annual incidence of first silent stroke in the United States: a preliminary estimate. Cerebrovasc Dis. 2003;16(3):280–5.
Wardlaw JM, Smith C, Dichgans M. Small vessel disease: mechanisms and clinical implications. Lancet Neurol. 2019;18(7):684–96.
Szcześniak D, Rymaszewska J, Zimny A, et al. Cerebral small vessel disease and other influential factors of cognitive impairment in the middle-aged: a long-term observational cohort PURE-MIND study in Poland. Geroscience. 2021;43(1):279–95.
Hilal S, Mok V, Youn YC, Wong A, Ikram MK, Chen CL. Prevalence, risk factors and consequences of cerebral small vessel diseases: data from three Asian countries. J Neurol Neurosurg Psychiatry. 2017;88:669–74.
Wang Z, Chen Q, Chen J, Yang N, Zheng K. Risk factors of cerebral small vessel disease: A systematic review and meta-analysis. Medicine (Baltimore). 2021;100(51):e28229.
Article CAS PubMed Google Scholar
Chojdak-Łukasiewicz J, Dziadkowiak E, Zimny A, Paradowski B. Cerebral small vessel disease: a review. Adv Clin Exp Med. 2021;30(3):349–56.
Pinter D, Ritchie SJ, Gattringer T, Bastin ME, del Hernández M, Corley J, et al. Predictors of gait speed and its change over three years in community-dwelling older people. Aging. 2018;10(1):144–53.
Article PubMed PubMed Central Google Scholar
Staals J, Booth T, Morris Z, Bastin ME, Gow AJ, Corley J, et al. Total MRI load of cerebral small vessel disease and cognitive ability in older people. Neurobiol Aging. 2015;36(10):2806–11.
Article PubMed PubMed Central Google Scholar
Bartel DP. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell. 2004;116:281–97.
Article CAS PubMed Google Scholar
Zhao Y, Ransom JF, Li A, Vedantham V, von Drehle M, Muth AN, et al. Dysregulation of cardiogenesis, cardiac conduction, and cell cycle in mice lacking MIRNA-1-2. Cell. 2007;129(2):303–17.
Article CAS PubMed Google Scholar
Carleton M, Cleary MA, Linsley PS. MicroRNAs and cell cycle regulation. Cell Cycle. 2007;6(17):2127–32.
Article CAS PubMed Google Scholar
Cheng CY, Chen SP, Liao YC, Fuh JL, Wang YF, Wang SJ. Elevated circulating endothelial-specific microRNAs in migraine patients: a pilot study. Cephalalgia. 2018;38(9):1585–91.
Soliman R, Mousa NO, Rashed HR, Moustafa RR, Hamdi N, Osman A, et al. Assessment of diagnostic potential of some circulating micrornas in amyotrophic lateral sclerosis patients, an Egyptian study. Clin Neurol Neurosurg. 2021;208: 106883.
Huang S, Zhao J, Huang D, Zhuo L, Liao S, Jiang Z. Serum Mir-132 is a risk marker of post-stroke cognitive impairment. Neurosci Lett. 2016;615:102–6.
Article CAS PubMed Google Scholar
Ragusa M, Bosco P, Tamburello L, et al. miRNAs Plasma Profiles in Vascular Dementia: Biomolecular Data and Biomedical Implications. Front Cell Neurosci. 2016;10:51.
Article PubMed PubMed Central Google Scholar
Wang C, Ji B, Cheng B, Chen J, Bai B. Neuroprotection of microRNA in neurological disorders (review). Biomed Rep. 2014;2(5):611–9.
Article CAS PubMed PubMed Central Google Scholar
Dharap A, Vemuganti R. Ischemic pre-conditioning alters cerebral micrornas that are upstream to neuroprotective signaling pathways. J Neurochem. 2010;113(6):1685–91.
Article CAS PubMed PubMed Central Google Scholar
Lusardi TA, Farr CD, Faulkner CL, Pignataro G, Yang T, Lan J, et al. Ischemic preconditioning regulates expression of micrornas and a predicted target, MECP2, in mouse cortex. J Cereb Blood Flow Metab. 2009;30(4):744–56.
Article PubMed PubMed Central Google Scholar
Smith EE, Markus HS. New treatment approaches to modify the course of cerebral small vessel diseases. Stroke. 2020;51(1):38–46.
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