Authors Keywords: applied pharmacokinetics, adjusted drug dosing, physiological states Abstract

A patient's age, weight, gender, and pathophysiological state are some factors that may necessitate the adjustment of drug dosing. In addition, pharmacokinetics and pharmacogenomics, drug-drug and food-drug interactions may further alter the pharmacokinetics and pharmacodynamics of a drug. In part I of this topic, the basic principles of pharmacokinetics and the physiological factors that affect drug dosing viz. extremes of age and pregnancy are discussed.

Author Biography S Mahomed, University of the Witwatersrand

Department of Anaesthesia, School of Clinical Medicine, Faculty of Health Sciences, Charlotte Maxeke Johannesburg Academic Hospital, University of the Witwatersrand, South Africa

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