Hansel C, Linden DJ, D’Angelo E. Beyond parallel fiber LTD: the diversity of synaptic and non-synaptic plasticity in the cerebellum. Nat Neurosci. 2001;4:467–75.
Article CAS PubMed Google Scholar
Johansen JP, Cain CK, Ostroff LE, LeDoux JE. Molecular mechanisms of fear learning and memory. Cell. 2011;147:509–24.
Article CAS PubMed PubMed Central Google Scholar
Kandel ER, Dudai Y, Mayford MR. The molecular and systems biology of memory. Cell. 2014;157:163–86.
Article CAS PubMed Google Scholar
Citri A, Malenka RC. Synaptic plasticity: multiple forms, functions, and mechanisms. Neuropsychopharmacology. 2008;33:18–41.
Magee JC, Grienberger C. Synaptic plasticity forms and functions. Annu Rev Neurosci. 2020;43:95–117.
Article CAS PubMed Google Scholar
Rumpel S, LeDoux J, Zador A, Malinow R. Postsynaptic receptor trafficking underlying a form of associative learning. Science. 2005;308:83–88.
Article CAS PubMed Google Scholar
Sacchetti B, Scelfo B, Tempia F, Strata P. Long-term synaptic changes induced in the cerebellar cortex by fear conditioning. Neuron. 2004;42:973–82.
Article CAS PubMed Google Scholar
Amano T, Unal CT, Pare D. Synaptic correlates of fear extinction in the amygdala. Nat Neurosci. 2010;13:489–94.
Article CAS PubMed PubMed Central Google Scholar
Mozzachiodi R, Byrne JH. More than synaptic plasticity: role of nonsynaptic plasticity in learning and memory. Trends Neurosci. 2010;33:17–26.
Article CAS PubMed Google Scholar
Debanne D, Inglebert Y, Russier M. Plasticity of intrinsic neuronal excitability. Curr Opin Neurobiol. 2019;54:73–82.
Article CAS PubMed Google Scholar
Nolan MF, Malleret G, Lee KH, Gibbs E, Dudman JT, Santoro B, et al. The hyperpolarization-activated HCN1 channel is important for motor learning and neuronal integration by cerebellar Purkinje cells. Cell. 2003;115:551–64.
Article CAS PubMed Google Scholar
Nolan MF, Malleret G, Dudman JT, Buhl DL, Santoro B, Gibbs E, et al. A behavioral role for dendritic integration: HCN1 channels constrain spatial memory and plasticity at inputs to distal dendrites of CA1 pyramidal neurons. Cell. 2004;119:719–32.
Kaczorowski CC, Disterhoft JF. Memory deficits are associated with impaired ability to modulate neuronal excitability in middle-aged mice. Learn Mem. 2009;16:362–6.
Article PubMed PubMed Central Google Scholar
Liu YZ, Wang Y, Shen W, Wang Z. Enhancement of synchronized activity between hippocampal CA1 neurons during initial storage of associative fear memory. J Physiol. 2017;595:5327–40.
Article CAS PubMed PubMed Central Google Scholar
Grasselli G, Boele HJ, Titley HK, Bradford N, van Beers L, Jay L, et al. SK2 channels in cerebellar Purkinje cells contribute to excitability modulation in motor-learning-specific memory traces. PLoS Biol. 2020;18:e3000596.
Article PubMed PubMed Central Google Scholar
Campanac E, Daoudal G, Ankri N, Debanne D. Downregulation of dendritic I(h) in CA1 pyramidal neurons after LTP. J Neurosci. 2008;28:8635–43.
Article CAS PubMed PubMed Central Google Scholar
Belmeguenai A, Hosy E, Bengtsson F, Pedroarena CM, Piochon C, Teuling E, et al. Intrinsic plasticity complements long-term potentiation in parallel fiber input gain control in cerebellar Purkinje cells. J Neurosci. 2010;30:13630–43.
Article CAS PubMed PubMed Central Google Scholar
Gasselin C, Inglebert Y, Debanne D. Homeostatic regulation of h-conductance controls intrinsic excitability and stabilizes the threshold for synaptic modification in CA1 neurons. J Physiol. 2015;593:4855–69.
Article CAS PubMed PubMed Central Google Scholar
Shim HG, Jang SS, Jang DC, Jin Y, Chang W, Park JM, et al. mGlu1 receptor mediates homeostatic control of intrinsic excitability through Ih in cerebellar Purkinje cells. J Neurophysiol. 2016;115:2446–55.
Article CAS PubMed PubMed Central Google Scholar
Turrigiano G. Homeostatic synaptic plasticity: local and global mechanisms for stabilizing neuronal function. Cold Spring Harb Perspect Biol. 2012;4:a005736.
Article PubMed PubMed Central Google Scholar
Wondolowski J, Dickman D. Emerging links between homeostatic synaptic plasticity and neurological disease. Front Cell Neurosci. 2013;7:223.
Article CAS PubMed PubMed Central Google Scholar
Dickman DK, Davis GW. The schizophrenia susceptibility gene dysbindin controls synaptic homeostasis. Science. 2009;326:1127–30.
Article CAS PubMed PubMed Central Google Scholar
Auerbach BD, Osterweil EK, Bear MF. Mutations causing syndromic autism define an axis of synaptic pathophysiology. Nature. 2011;480:63–68.
Article CAS PubMed PubMed Central Google Scholar
Kakegawa W, Miyazaki T, Emi K, Matsuda K, Kohda K, Motohashi J, et al. Differential regulation of synaptic plasticity and cerebellar motor learning by the C-terminal PDZ-binding motif of GluRdelta2. J Neurosci. 2008;28:1460–8.
Article CAS PubMed PubMed Central Google Scholar
Boyden ES, Katoh A, Pyle JL, Chatila TA, Tsien RW, Raymond JL. Selective engagement of plasticity mechanisms for motor memory storage. Neuron. 2006;51:823–34.
Article CAS PubMed Google Scholar
Ito M, Yamaguchi K, Nagao S, Yamazaki T. Long-term depression as a model of cerebellar plasticity. Prog Brain Res. 2014;210:1–30.
Shim HG, Jang DC, Lee J, Chung G, Lee S, Kim YG, et al. Long-term depression of intrinsic excitability accompanied by synaptic depression in cerebellar purkinje cells. J Neurosci. 2017;37:5659–69.
Article CAS PubMed PubMed Central Google Scholar
Shim HG, Lee YS, Kim SJ. The emerging concept of intrinsic plasticity: activity-dependent modulation of intrinsic excitability in cerebellar purkinje cells and motor learning. Exp Neurobiol. 2018;27:139–54.
Article PubMed PubMed Central Google Scholar
Jang DC, Kim SJ. Plasticity leading to cerebellum-dependent learning: two different regions, two different types. Pflugers Arch. 2019;471:927–34.
Article CAS PubMed Google Scholar
Jang DC, Shim HG, Kim SJ. Intrinsic plasticity of cerebellar purkinje cells contributes to motor memory consolidation. J Neurosci. 2020;40:4145–57.
Article CAS PubMed PubMed Central Google Scholar
Sacchetti B, Baldi E, Lorenzini CA, Bucherelli C. Cerebellar role in fear-conditioning consolidation. Proc Natl Acad Sci USA. 2002;99:8406–11.
Article CAS PubMed PubMed Central Google Scholar
Zhu L, Scelfo B, Hartell NA, Strata P, Sacchetti B. The effects of fear conditioning on cerebellar LTP and LTD. Eur J Neurosci. 2007;26:219–27.
Scelfo B, Sacchetti B, Strata P. Learning-related long-term potentiation of inhibitory synapses in the cerebellar cortex. Proc Natl Acad Sci USA. 2008;105:769–74.
Article CAS PubMed PubMed Central Google Scholar
Liu Y, Formisano L, Savtchouk I, Takayasu Y, Szabo G, Zukin RS, et al. A single fear-inducing stimulus induces a transcription-dependent switch in synaptic AMPAR phenotype. Nat Neurosci. 2010;13:223–31.
Article CAS PubMed Google Scholar
Koutsikou S, Crook JJ, Earl EV, Leith JL, Watson TC, Lumb BM, et al. Neural substrates underlying fear-evoked freezing: the periaqueductal grey-cerebellar link. J Physiol. 2014;592:2197–213.
Article CAS PubMed PubMed Central Google Scholar
Lawrenson C, Paci E, Pickford J, Drake RAR, Lumb BM, Apps R. Cerebellar modulation of memory encoding in the periaqueductal grey and fear behaviour. Elife. 2022;11:e76278.
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