Kocks JW, Tuinenga MG, Uil SM, Van den Berg JW, Ståhl E, Van Der Molen T. Health status measurement in COPD: the minimal clinically important difference of the clinical COPD questionnaire. Respir Res. 2006;7:1–8.
Kakavas S, Kotsiou OS, Perlikos F, Mermiri M, Mavrovounis G, Gourgoulianis K, Pantazopoulos I. Pulmonary function testing in COPD: looking beyond the curtain of FEV1. NPJ Prim Care Respir Med. 2021;31(1):23.
Article PubMed PubMed Central Google Scholar
Kellerer C, Jörres RA, Schneider A, Alter P, Kauczor HU, Jobst B, Biederer J, Bals R, Watz H, Behr J, Kauffmann-Guerrero D. Prediction of lung emphysema in COPD by spirometry and clinical symptoms: results from COSYCONET. Respir Res. 2021;22:1–1.
Eberlein M, Schmidt GA, Brower RG. Chest wall strapping. An old physiology experiment with new relevance to small airways diseases. Ann Am Thorac Soc. 2014;11(8):1258–66.
Article PubMed PubMed Central Google Scholar
Janssens W, Liu Y, Liu D, Kesten S, Tashkin DP, Celli BR, Decramer M. Quality and reproducibility of spirometry in COPD patients in a randomized trial (UPLIFT®). Respir Med. 2013;107(9):1409–16.
Article CAS PubMed Google Scholar
Lipson DA, Barnacle H, Birk R, Brealey N, Locantore N, Lomas DA, Ludwig-Sengpiel A, Mohindra R, Tabberer M, Zhu CQ, Pascoe SJ. FULFIL trial: once-daily triple therapy for patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2017;196(4):438–46.
Article CAS PubMed Google Scholar
Ramírez-Venegas A, Velázquez-Uncal M, Aranda-Chávez A, Guzmán-Bouilloud NE, Mayar-Maya ME, Pérez Lara-Albisua JL, Hernandez-Zenteno RD, Flores-Trujillo F, Sansores RH. Bronchodilators for hyperinflation in COPD associated with biomass smoke: clinical trial. Int J Chron Obstruct Pulmon Dis. 2019;6:1753–62.
Juan CA, Pérez de la Lastra JM, Plou FJ, Pérez-Lebeña E. The chemistry of reactive oxygen species (ROS) revisited: outlining their role in biological macromolecules (DNA, lipids and proteins) and induced pathologies. Int J Mol Sci. 2021;22(9):4642.
Article CAS PubMed PubMed Central Google Scholar
Sunnetcioglu A, Alp HH, Sertogullarından B, Balaharoglu R, Gunbatar H. Evaluation of oxidative damage and antioxidant mechanisms in COPD, lung cancer, and obstructive sleep apnea syndrome. Respir Care. 2016;61(2):205–11.
Dailah HG. Therapeutic potential of small molecules targeting oxidative stress in the treatment of chronic obstructive pulmonary disease (COPD): a comprehensive review. Molecules. 2022;27(17):5542.
Article CAS PubMed PubMed Central Google Scholar
Dekany M, Nemeskeri V, Györe I, Harbula I, Malomsoki J, Pucsok J. Antioxidant status of interval-trained athletes in various sports. Int J Sports Med. 2005;30:112–6.
Heijink IH, Brandenburg SM, Postma DS, van Oosterhout AJ. Cigarette smoke impairs airway epithelial barrier function and cell–cell contact recovery. Eur Respir J. 2012;39(2):419–28.
Article CAS PubMed Google Scholar
Dal Negro RW, Visconti M, Turco P. Efficacy of erdosteine 900 versus 600 mg/day in reducing oxidative stress in patients with COPD exacerbations: results of a double blind, placebo-controlled trial. Pulm Pharmacol Ther. 2015;1(33):47–51.
Singh S, Verma SK, Kumar S, Ahmad MK, Nischal A, Singh SK, Dixit RK. Evaluation of oxidative stress and antioxidant status in chronic obstructive pulmonary disease. Scand J Immunol. 2017;85(2):130–7.
Article CAS PubMed Google Scholar
Agacdiken A, Basyigit I, Özden M, Yildiz F, Ural D, Maral H, Boyaci H, Ilgazli A, Komsuoglu B. The effects of antioxidants on exercise-induced lipid peroxidation in patients with COPD. Respirology. 2004;9(1):38–42.
Chillappagari S, Preuss J, Licht S, Müller C, Mahavadi P, Sarode G, Vogelmeier C, Guenther A, Nahrlich L, Rubin BK, Henke MO. Altered protease and antiprotease balance during a COPD exacerbation contributes to mucus obstruction. Respir Res. 2015;16(1):1–9.
Lu P, Takai K, Weaver VM, Werb Z. Extracellular matrix degradation and remodeling in development and disease. Cold Spring Harb Perspect Biol. 2011;3(12): a005058.
Article PubMed PubMed Central Google Scholar
Janciauskiene SM, Bals R, Koczulla R, Vogelmeier C, Köhnlein T, Welte T. The discovery of α1-antitrypsin and its role in health and disease. Respir Med. 2011;105(8):1129–39.
Geraghty P, Rogan MP, Greene CM, Brantly ML, O’Neill SJ, Taggart CC, McElvaney NG. Alpha-1-antitrypsin aerosolized augmentation abrogates neutrophil elastase-induced expression of cathepsin B and matrix metalloprotease 2 in vivo and in vitro. Thorax. 2008;63(7):621–6.
Article CAS PubMed Google Scholar
Ghosh A, Coakley RD, Ghio AJ, Muhlebach MS, Esther CR Jr, Alexis NE, Tarran R. Chronic e-cigarette use increases neutrophil elastase and matrix metalloprotease levels in the lung. Am J Respir Crit Care Med. 2019;200(11):1392–401.
Article CAS PubMed PubMed Central Google Scholar
Liu T, Zhang L, Joo D, Sun SC. NF-κB signaling in inflammation. Signal Transduct Target Ther. 2017;2(1):1–9.
Babkina II, Sergeeva SP, Gorbacheva LR. The role of NF-κB in neuroinflammation. Neurochem J. 2021;15(2):114–28.
Sun SC. The non-canonical NF-κB pathway in immunity and inflammation. Nat Rev Immunol. 2017;17(9):545–58.
Article CAS PubMed PubMed Central Google Scholar
Milnerowicz H, Ściskalska M, Dul M. Molecular mechanisms of the impact of smoke-oxidants. Exp Toxicol Pathol. 2015;67(7–8):377–82.
Article CAS PubMed Google Scholar
Akata K, Yamasaki K, Leitao Filho FS, Yang CX, Takiguchi H, Sahin B, Whalen BA, Yang CW, Leung JM, Sin DD, van Eeden SF. Abundance of non-polarized lung macrophages with poor phagocytic function in Chronic obstructive pulmonary disease (COPD). Biomedicines. 2020;8(10):398.
Article CAS PubMed PubMed Central Google Scholar
Ando M, Magi S, Seki M, Suzuki Y, Kasukawa T, Lefaudeux D, Hoffmann A, Okada M. IκBα is required for full transcriptional induction of some NFκB-regulated genes in response to TNF in MCF-7 cells. NPJ Syst Biol Appl. 2021;7(1):42.
Article CAS PubMed PubMed Central Google Scholar
Lennikov A, Mirabelli P, Mukwaya A, Schaupper M, Thangavelu M, Lachota M, Lagali N, et al. Selective IKK2 inhibitor IMD0354 disrupts NF-κB signaling to suppress corneal inflammation and angiogenesis. Angiogenesis. 2018;21(2):267–85.
Article CAS PubMed PubMed Central Google Scholar
Chen KK, Minakuchi M, Wuputra K, Ku CC, Pan JB, Kuo KK, Yokoyama KK, et al. Redox control in the pathophysiology of influenza virus infection. BMC Microbiol. 2020;20(1):1–22.
Mayer IA, Arteaga CL. The PI3K/AKT pathway as a target for cancer treatment. Annu Rev Med. 2016;67:11–28.
Article CAS PubMed Google Scholar
Chalhoub N, Baker SJ. PTEN and the PI3-kinase pathway in cancer. Annu Rev Pathol. 2009;4:127–50.
Article CAS PubMed PubMed Central Google Scholar
Zhang X, Tang N, Hadden TJ, Rishi AK. Akt, FoxO and regulation of apoptosis. Biochim Biophys Acta Mol Cell Res. 2011;2011(11):1978–86.
Liu H, Yin T, Yan W, Si R, Wang B, Chen M, Li F, Wang Q, Tao L. Dysregulation of microRNA-214 and PTEN contributes to the pathogenesis of hypoxic pulmonary hypertension. Int J Chron Obstruct Pulmon Dis. 2017;19:1781–91.
Baker JR, Vuppusetty C, Colley T, Papaioannou AI, Fenwick P, Donnelly L, Barnes PJ, et al. Oxidative stress dependent microRNA-34a activation via PI3Kα reduces the expression of sirtuin-1 and sirtuin-6 in epithelial cells. Sci Rep. 2016;6(1):1–13.
Smith MC, Wrobel JP. Epidemiology and clinical impact of major comorbidities in patients with COPD. Int J Chron Obstruct Pulmon Dis. 2014;9:871.
Article PubMed PubMed Central Google Scholar
Gwynne M, Mounsey A. Would this long-acting bronchodilator be better for your patient? J Fam Pract. 2012;61(2):94.
PubMed PubMed Central Google Scholar
Jones RL, Noble PB, Elliot JG, James AL. Airway remodelling in COPD: it’s not asthma! Respirology. 2016;21(8):1347–56.
LaPreze J. Management of stable chronic obstructive pulmonary disease. US Pharm. 2013;38(7):43–6.
Tretter V, Hochreiter B, Zach ML, Krenn K, Klein KU. Understanding cellular redox homeostasis: a challenge for precision medicine. Int J Mol Sci. 2021;23(1):106.
Comments (0)