Hall W. What has research over the past two decades revealed about the adverse health effects of recreational cannabis use? Addiction. 2015;110:19–35.

Article  PubMed  Google Scholar 

Lowe DJE, Sasiadek JD, Coles AS, George TP. Cannabis and mental illness: a review. Eur Arch Psychiatry Clin Neurosci. 2019;269:107–20.

Article  PubMed  Google Scholar 

Volkow ND, Baler RD, Compton WM, Weiss SRB. Adverse health effects of marijuana use. N Engl J Med. 2014;370:2219–27.

Article  PubMed  PubMed Central  Google Scholar 

Hall W, Lynskey M. Evaluating the public health impacts of legalizing recreational cannabis use in the United States. Addiction. 2016;111:1764–73.

Article  PubMed  Google Scholar 

Hall W, Weier M. Assessing the public health impacts of legalizing recreational cannabis use in the USA. Clin Pharmacol Ther. 2015;97:607–15.

Article  CAS  PubMed  Google Scholar 

Nigatu YT, Elton-Marshall T, Rueda S, Imtiaz S, Hamilton HA. Age, period and cohort effects on time trends in monthly cannabis use in adult population: 1996–2019. Drug Alcohol Rev. 2023; https://doi.org/10.1111/dar.13658.

Article  PubMed  Google Scholar 

Siegel RL, Miller KD, Wagle NS, Jemal A. Cancer statistics. CA A Cancer J Clinicians. 2023;73:17–48.

Article  Google Scholar 

Ghasemiesfe M, Barrow B, Leonard S, Keyhani S, Korenstein D. Association between Marijuana use and risk of cancer: a systematic review and meta-analysis. JAMA Netw Open. 2019;2:e1916318.

Article  PubMed  PubMed Central  Google Scholar 

Erzurumlu Y, Catakli D, Sezer S. Cannabidiol negatively regulates androgenic signal in prostate cancer cells and fine-tunes the tumorigenesis by modulating endoplasmic reticulum-associated degradation, unfolded protein response, and autophagy. Rev Bras Farmacogn. 2023;33:316–25.

Article  CAS  Google Scholar 

Motadi LR, Jantjies ZE, Moleya B. Cannabidiol and Cannabis Sativa as a potential treatment in vitro prostate cancer cells silenced with RBBp6 and PC3 xenograft. Mol Biol Rep. 2023; https://doi.org/10.1007/s11033-022-08197-0.

Article  PubMed  PubMed Central  Google Scholar 

Whynot EG, Tomko AM, Dupré DJ. Anticancer properties of cannabidiol and ∆9-tetrahydrocannabinol and synergistic effects with gemcitabine and cisplatin in bladder cancer cell lines. J Cannabis Res. 2023;5:7.

Article  PubMed  PubMed Central  Google Scholar 

Zhong N, Li D, Wang B, Kovalchuk O, Kovalchuk I. Cannabinol inhibits cell growth and triggers cell cycle arrest and apoptosis in cancer cells. Biocatal Agric Biotechnol. 2023;48:102627.

Article  CAS  Google Scholar 

AminiLari M, Wang L, Neumark S, Adli T, Couban RJ, Giangregorio A, et al. Medical cannabis and cannabinoids for impaired sleep: a systematic review and meta-analysis of randomized clinical trials. Sleep. 2022;45:zsab234.

Article  PubMed  Google Scholar 

Croker JA, Bobitt J, Arora K, Kaskie B. Cannabis and palliative care utilization among non-terminal cancer patients in the illinois medical cannabis program. Psychoactives. 2023;2:52–65.

Article  Google Scholar 

Jafri S, Hansen E, Fuenmayor R, Case AA. Medical Cannabis for insomnia in a patient with advanced breast cancer. J Pain Symptom Manage. 2023;65:e497–e502.

Article  PubMed  Google Scholar 

Wang L, Hong PJ, May C, Rehman Y, Oparin Y, Hong CJ, et al. Medical cannabis or cannabinoids for chronic non-cancer and cancer related pain: a systematic review and meta-analysis of randomised clinical trials. BMJ. 2021; https://doi.org/10.1136/bmj.n1034.

Article  PubMed  PubMed Central  Google Scholar 

Smith DG, Ebrahim S. ‘Mendelian randomization’: can genetic epidemiology contribute to understanding environmental determinants of disease? Int J Epidemiol. 2003;32:1–22.

Article  PubMed  Google Scholar 

Hemani G, Zheng J, Elsworth B, Wade KH, Haberland V, Baird D, et al. The MR-Base platform supports systematic causal inference across the human phenome. Elife. 2018;7:e34408.

Article  PubMed  PubMed Central  Google Scholar 

Voirin N, Berthiller J, Benhaïm-Luzon V, Boniol M, Straif K, Ayoub WB, et al. Risk of lung cancer and past use of cannabis in Tunisia. J Thorac Oncol. 2006;1:577–9.

Article  PubMed  Google Scholar 

Bouti K, Borki R, Fenane H, Harrak L. Cannabis smoking and risk of lung cancer—a systematic review and meta-analysis. IJMS. 2014;1:31–7.

Article  Google Scholar 

Takeda S, Yamamoto I, Watanabe K. Modulation of Delta9-tetrahydrocannabinol-induced MCF‑7 breast cancer cell growth by cyclooxygenase and aromatase. Toxicology. 2009;259:25–32.

Article  CAS  PubMed  Google Scholar 

Ligresti A, Moriello AS, Starowicz K, Matias I, Pisanti S, De Petrocellis L, et al. Antitumor activity of plant cannabinoids with emphasis on the effect of cannabidiol on human breast carcinoma. J Pharmacol Exp Ther. 2006;318:1375–87.

Article  CAS  PubMed  Google Scholar