Incidence and Clinicopathologic Characteristics of Human Papillomavirus–independent Invasive Squamous Cell Carcinomas of the Cervix: A Morphologic, Immunohistochemical, and Human Papilloma-Virologic Study of 670 Cases

*Department of Pathology, University of Medicine, Pharmacy, Science and Technology “George E Palade” of Targu Mures, Targu Mures

¶Regional Institute of Oncology, Iasi, Romania

Departments of †Pathology

‡Surgery

§Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center

¶¶Department of Obstetrics and Gynecology, Weill Cornell Medical College, New York, NY

∥Department of Pathology, Vancouver General Hospital, Vancouver, BC, Canada

#Hospital “Sacro Cuore Don Calabria”, Negrar, Italy

**Department of Pathology, Sahlgrenska University Hospital, Gothenburg, Sweden

††Department of Pathology, University of Chicago, Chicago, IL

‡‡Department of Pathology, The Jikei University School of Medicine, Tokyo, Japan

§§Department of Pathology, Wayne State University, Detroit, MI

∥∥Massachusetts General Hospital, Boston, MA

S.S. and D.A. are co-contributing first authors.

Conflicts of Interest and Source of Funding: Funded in part by the National Institutes of Health (NIH)/National Cancer Institute (NCI) Cancer Center Support Grant P30 CA008748. Outside the submitted work, N.R.A.-R. reports research funding paid to the institution from GRAIL. A.I. reports consulting fees from Mylan. For the remaining authors none were declared.

Correspondence: Simona Stolnicu, MD, PhD, Department of Pathology, University of Medicine, Pharmacy, Science and Technology of Targu Mures, 38 Gheorghe Marinescu Street, Targu Mures 540139, Romania (e-mail: [email protected]).

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