WHO. HIV 2021. https://www.who.int/data/gho/data/themes/hiv-aids#:~:text=Globally%2C%2038.4%20million%20%5B33.9%E2%80%93,considerably%20between%20countries%20and%20regions.

Collaboration H-C, Ray M, Logan R, Sterne JA, Hernandez-Diaz S, Robins JM, et al. The effect of combined antiretroviral therapy on the overall mortality of HIV-infected individuals. AIDS. 2010;24(1):123–37.

Article  Google Scholar 

Safdari R, Ahmadi M, Bahaadinbeigy K, Farzi J, Noori T, Mehraeen E. Identifying and validating requirements of telemental health services for Iranian veterans. J Family Med Primary Care. 2019;8(3):1216–21.

Article  Google Scholar 

Mehraeen E, Safdari R, SeyedAlinaghi S, Noori T, Kahouei M, Soltani-Kermanshahi M. A mobile-based self-management application- usability evaluation from the perspective of HIV-positive people. Health Policy Technol. 2020;9(3):294–301.

Article  Google Scholar 

Mehraeen E, Safdari R, Seyedalinaghi SA, Mohammadzadeh N, Arji G. Identifying and validating requirements of a mobile-based self-management system for people living with HIV. Stud Health Technol Inform. 2018;248:140–7.

PubMed  Google Scholar 

Baeten JM, Kahle E, Lingappa JR, Coombs RW, Delany-Moretlwe S, Nakku-Joloba E, et al. Genital HIV-1 RNA predicts risk of heterosexual HIV-1 transmission. Sci Transl Med. 2011;3(77):77ra29.

Article  PubMed  PubMed Central  Google Scholar 

Graham SM, Holte SE, Peshu NM, Richardson BA, Panteleeff DD, Jaoko WG, et al. Initiation of antiretroviral therapy leads to a rapid decline in cervical and vaginal HIV-1 shedding. AIDS. 2007;21(4):501–7.

Article  PubMed  Google Scholar 

Vernazza PL, Troiani L, Flepp MJ, Cone RW, Schock J, Roth F, et al. Potent antiretroviral treatment of HIV-infection results in suppression of the seminal shedding of HIV. Swiss HIV Cohort Study AIDS. 2000;14(2):117–21.

CAS  Google Scholar 

https://www.unaids.org/en/resources/fact-sheet. UGHAsFsAf.

UNAIDS F-TT, UNAIDS, Editor. 2014.

Severe P, Juste MA, Ambroise A, Eliacin L, Marchand C, Apollon S, et al. Early versus standard antiretroviral therapy for HIV-infected adults in Haiti. N Engl J Med. 2010;363(3):257–65.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mirzapour P, Motlagh F, SeyedAlinaghi S, Mehraeen E. Comparison of the effectiveness of positive thinking training and acceptance and commitment therapy on quality of life and resilience of people living with HIV. HIV AIDS Rev Int J HIV Related Probl. 2021. https://doi.org/10.5114/hivar.2021.112404.

Article  Google Scholar 

Mehraeen E, Salehi MA, Behnezhad F, Moghaddam HR, SeyedAlinaghi S. Transmission modes of COVID-19: a systematic review. Infect Disord Drug Targets. 2021;21(6):e170721187995.

Article  CAS  PubMed  Google Scholar 

CDC. HIV in the United States. 2019.

WHO. Consolidated guidelines on the use of antiretroviral drugs for treating and preventing HIV infection: recommendations for a public health approach, 2nd ed2016. https://www.who.int/publications/i/item/9789241549684.

Shahmohamadi E, SeyedAlinaghi S, Karimi A, Behnezhad F, Mehraeen E, Dadras O. HIV/HTLV-1 co-infection: a systematic review of current evidence. HIV & AIDS Rev Int J HIV Relat Probl. 2021;20(3):158–65.

Article  Google Scholar 

Castley A, Sawleshwarkar S, Varma R, Herring B, Thapa K, Dwyer D, et al. A national study of the molecular epidemiology of HIV-1 in Australia 2005–2012. PLoS ONE. 2017;12(5):e0170601.

Article  PubMed  PubMed Central  Google Scholar 

Arimide DA, Abebe A, Kebede Y, Adugna F, Tilahun T, Kassa D, et al. HIV-genetic diversity and drug resistance transmission clusters in Gondar, Northern Ethiopia, 2003–2013. PLoS ONE. 2018;13(10):e0205446.

Article  PubMed  PubMed Central  Google Scholar 

Maldarelli F, Kearney M, Palmer S, Stephens R, Mican J, Polis MA, et al. HIV populations are large and accumulate high genetic diversity in a nonlinear fashion. J Virol. 2013;87(18):10313–23.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lessells R, Katzenstein D, De Oliveira T. Are subtype differences important in HIV drug resistance? Curr Opin Virol. 2012;2(5):636–43.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kiepiela P, Manasa J, Moosa M-Y, Moodley P, Gordon M, Parikh UM, et al. HIV drug resistance patterns at the epicentre of the HIV-1 epidemic in Kwazulu-Natal, South Africa 2003–2013. J AIDS Clin Res. 2014;5(5):299.

Article  Google Scholar 

Skhosana L, Steegen K, Bronze M, Lukhwareni A, Letsoalo E, Papathanasopoulos MA, et al. High prevalence of the K65R mutation in HIV-1 subtype C infected patients failing tenofovir-based first-line regimens in South Africa. PLoS ONE. 2015;10(2):e0118145.

Article  PubMed  PubMed Central  Google Scholar 

Palmer NB, Salcedo J, Miller AL, Winiarski M, Arno P. Psychiatric and social barriers to HIV medication adherence in a triply diagnosed methadone population. AIDS Patient Care STDS. 2003;17(12):635–44.

Article  PubMed  Google Scholar 

McCluskey SM, Siedner MJ, Marconi VC. Management of virologic failure and HIV drug resistance. Infect Dis Clin North Am. 2019;33(3):707–42.

Article  PubMed  PubMed Central  Google Scholar 

Parienti JJ, Bangsberg DR, Verdon R, Gardner EM. Better adherence with once-daily antiretroviral regimens: a meta-analysis. Clin Infect Dis. 2009;48(4):484–8.

Article  PubMed  Google Scholar 

NIH. ART Therapy in Adults and Adolescents. 2018. https://indd.adobe.com/view/0380886a-52e0-4434-80be-0da162be7d87.

Nettles RE, Kieffer TL, Kwon P, Monie D, Han Y, Parsons T, et al. Intermittent HIV-1 viremia (Blips) and drug resistance in patients receiving HAART. JAMA. 2005;293(7):817–29.

Article  CAS  PubMed  Google Scholar 

Sungkanuparph S, Overton ET, Seyfried W, Groger RK, Fraser VJ, Powderly WG. Intermittent episodes of detectable HIV viremia in patients receiving nonnucleoside reverse-transcriptase inhibitor-based or protease inhibitor-based highly active antiretroviral therapy regimens are equivalent in incidence and prognosis. Clin Infect Dis. 2005;41(9):1326–32.

Article  CAS  PubMed  Google Scholar 

Hermans LE, Moorhouse M, Carmona S, Grobbee DE, Hofstra LM, Richman DD, et al. Effect of HIV-1 low-level viraemia during antiretroviral therapy on treatment outcomes in WHO-guided South African treatment programmes: a multicentre cohort study. Lancet Infect Dis. 2018;18(2):188–97.

Article  PubMed  Google Scholar 

Aberg JA, Mills A, Moreno S, Slater J, Prakash M, Clark A. The evolution of clinical study design in heavily treatment-experienced persons with HIV: a critical review. Antivir Ther. 2023;28(3):13596535231174774.

Article  CAS  PubMed  Google Scholar 

Agegnehu CD, Techane MA, Mersha AT, Atalell KA. Burden and associated factors of virological failure among people living with HIV in Sub-Saharan Africa: a systematic review and meta-analysis. AIDS Behav. 2022;26(10):3327–36.

Article  PubMed  Google Scholar 

Almeida-Brasil CC, Moodie EEM, Cardoso TS, Nascimento ED, Ceccato M. Comparison of the predictive performance of adherence measures for virologic failure detection in people living with HIV: a systematic review and pairwise meta-analysis. AIDS Care. 2019;31(6):647–59.

Article  PubMed  Google Scholar 

Anderson K, Muloiwa R, Davies MA. Long-term outcomes in perinatally HIV-infected adolescents and young adults on antiretroviral therapy: a review of South African and global literature. Afr J AIDS Res. 2020;19(1):1–12.

Article  PubMed  Google Scholar 

Bernab Crossed D, Sign© KJ, Siedner M, Tsai AC, Marconi VC, Murphy RA. Detection of HIV Virologic failure and switch to second-line therapy: a systematic review and meta-analysis of data from Sub-Saharan Africa. Open Forum Infect Dis. 2022. https://doi.org/10.1093/ofid/ofac121.

Article  Google Scholar 

Bertagnolio S, Hermans L, Jordan MR, Avila-Rios S, Iwuji C, Derache A, et al. Clinical impact of pretreatment human immunodeficiency virus drug resistance in people initiating nonnucleoside reverse transcriptase inhibitor-containing antiretroviral therapy: a systematic review and meta-analysis. J Infect Dis. 2021;224(3):377–88.

Article  CAS  PubMed  Google Scholar 

Bezabhe WM, Chalmers L, Bereznicki LR, Peterson GM. Adherence to Antiretroviral therapy and virologic failure: a meta-analysis. Medicine (Baltimore). 2016;95(15):e3361.

Article  CAS  PubMed  Google Scholar 

Blanco JL, Marcelin AG, Katlama C, Martinez E. Dolutegravir resistance mutations: lessons from monotherapy studies. Curr Opin Infect Dis. 2018;31(3):237–45.

Article  CAS  PubMed  Google Scholar 

Borges ÁH, Lundh A, Tendal B, Bartlett JA, Clumeck N, Costagliola D, et al. Nonnucleoside reverse-transcriptase inhibitor- vs ritonavir-boosted protease inhibitor-based regimens for initial treatment of HIV infection: a systematic review and meta analysis of randomized trials. Clin Infect Dis. 2016;63(2):268–80.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cevik M, Orkin C, Sax PE. Emergent resistance to dolutegravir among instinaive patients on first-line or second-line antiretroviral therapy: a review of published cases. Open Forum Infect Dis. 2020. https://doi.org/10.1093/ofid/ofaa202.

Article  PubMed  PubMed Central  Google Scholar 

Cruciani M, Parisi SG. Dolutegravir based antiretroviral therapy compared to other combined antiretroviral regimens for the treatment of HIV-infected naive patients: a systematic review and meta-analysis. PLoS ONE. 2019;14(9):e0222229.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cruz ML, Cardoso CA. Perinatally infected adolescents living with human immunodeficiency virus (Perinatally human immunodeficiency virus). World J Virol. 2015;4(3):277–84.

Article  PubMed  PubMed Central  Google Scholar 

Daltro ACB, Almeida CS, Unfried AGC, de Aquino TR, Travassos A. Virological failure and adherence to antiretroviral therapy