Singer M, Deutschman CS, Seymour CW, Shankar-Hari M, Annane D, Bauer M, Bellomo R, Bernard GR, Chiche J-D, Coopersmith CM (2016) The third international consensus definitions for sepsis and septic shock (Sepsis-3). JAMA 315(8):801–810
Article CAS PubMed PubMed Central Google Scholar
Park I, Kim M, Choe K, Song E, Seo H, Hwang Y, Ahn J, Lee S-H, Lee JH, Jo YH (2019) Neutrophils disturb pulmonary microcirculation in sepsis-induced acute lung injury. Eur Respir J 53(3):1800786
Article CAS PubMed PubMed Central Google Scholar
Rubenfeld GD, Caldwell E, Peabody E, Weaver J, Martin DP, Neff M, Stern EJ, Hudson LD (2005) Incidence and outcomes of acute lung injury. N Engl J Med 353(16):1685–1693
Article CAS PubMed Google Scholar
Qiu N, Xu X, He Y (2020) LncRNA TUG1 alleviates sepsis-induced acute lung injury by targeting miR-34b-5p/GAB1. BMC Pulm Med 20(1):1–12
Ren Y, Li L, Wang M-M, Cao L-P, Sun Z-R, Yang Z-Z, Zhang W, Zhang P, Nie S-N (2021) Pravastatin attenuates sepsis-induced acute lung injury through decreasing pulmonary microvascular permeability via inhibition of Cav-1/eNOS pathway. Int Immunopharmacol 100:108077
Article CAS PubMed Google Scholar
Zou Z, Wang Q, Zhou M, Li W, Zheng Y, Li F, Zheng S, He Z (2020) Protective effects of P2X7R antagonist in sepsis-induced acute lung injury in mice via regulation of circ_0001679 and circ_0001212 and downstream Pln, Cdh2, and Nprl3 expression. J Gene Med 22(12):e3261
Article CAS PubMed Google Scholar
Hotchkiss RS, Coopersmith CM, McDunn JE, Ferguson TA (2009) The sepsis seesaw: tilting toward immunosuppression. Nat Med 15(5):496–497
Article CAS PubMed PubMed Central Google Scholar
Christaki E, Anyfanti P, Opal SM (2011) Immunomodulatory therapy for sepsis: an update. Expert Rev Anti Infect Ther 9(11):1013–1033
Article CAS PubMed Google Scholar
Wang Z, Kong L, Tan S, Zhang Y, Song X, Wang T, Lin Q, Wu Z, Xiang P, Li C (2020) Zhx2 accelerates sepsis by promoting macrophage glycolysis via Pfkfb3. J Immunol 204(8):2232–2241
Article CAS PubMed Google Scholar
Xia H, Chen L, Liu H, Sun Z, Yang W, Yang Y, Cui S, Li S, Wang Y, Song L (2017) Protectin DX increases survival in a mouse model of sepsis by ameliorating inflammation and modulating macrophage phenotype. Sci Rep 7(1):1–11
Lu X-J, Chen J, Yu C-H, Shi Y-H, He Y-Q, Zhang R-C, Huang Z-A, Lv J-N, Zhang S, Xu L (2013) LECT2 protects mice against bacterial sepsis by activating macrophages via the CD209a receptor. J Exp Med 210(1):5–13
Article CAS PubMed PubMed Central Google Scholar
Deng H, Wu L, Liu M, Zhu L, Chen Y, Zhou H, Shi X, Wei J, Zheng L, Hu X (2020) Bone marrow mesenchymal stem cell-derived exosomes attenuate LPS-induced ARDS by modulating macrophage polarization through inhibiting glycolysis in macrophages. Shock 54(6):828–843
Article CAS PubMed Google Scholar
Kelly B, O’neill LA (2015) Metabolic reprogramming in macrophages and dendritic cells in innate immunity. Cell Res 25(7):771–784
Article PubMed PubMed Central Google Scholar
Chen Q, Shao X, He Y, Lu E, Zhu L, Tang W (2021) Norisoboldine attenuates sepsis-induced acute lung injury by modulating macrophage polarization via PKM2/HIF-1α/PGC-1α pathway. Biol Pharm Bull 44(10):1536–1547
Article CAS PubMed Google Scholar
Yuan H, Han Y, Wang X, Li N, Liu Q, Yin Y, Wang H, Pan L, Li L, Song K (2020) SETD2 restricts prostate cancer metastasis by integrating EZH2 and AMPK signaling pathways. Cancer Cell 38(3):350-365. e7
Article CAS PubMed Google Scholar
Wang L, Niu N, Li L, Shao R, Ouyang H, Zou W (2018) H3K36 trimethylation mediated by SETD2 regulates the fate of bone marrow mesenchymal stem cells. PLoS Biol 16(11):e2006522
Article PubMed PubMed Central Google Scholar
Kim Y, Nam HJ, Lee J, Kim C, Yu YS, Kim D, Park SW, Bhin J, Hwang D, Lee H (2016) Methylation-dependent regulation of HIF-1α stability restricts retinal and tumour angiogenesis. Nat Commun 7(1):1–14
Lee J, Park J, Choi H, Won H, Joo H, Shin D, Park M, Han B, Kim K, Lee T (2017) LSD1 demethylates HIF1α to inhibit hydroxylation and ubiquitin-mediated degradation in tumor angiogenesis. Oncogene 36(39):5512–5521
Article CAS PubMed Google Scholar
Liu J, Hanavan PD, Kras K, Ruiz YW, Castle EP, Lake DF, Chen X, O’Brien D, Luo H, Robertson KD (2018) Loss of SETD2 induces a metabolic switch in renal cell carcinoma cell lines toward enhanced oxidative phosphorylation. J Proteome Res 18(1):331–340
PubMed PubMed Central Google Scholar
Tong Y, Yu Z, Chen Z, Zhang R, Ding X, Yang X, Niu X, Li M, Zhang L, Billiar TR (2021) The HIV protease inhibitor Saquinavir attenuates sepsis-induced acute lung injury and promotes M2 macrophage polarization via targeting matrix metalloproteinase-9. Cell Death Dis 12(1):1–14
Yuan H, Li N, Fu D, Ren J, Hui J, Peng J, Liu Y, Qiu T, Jiang M, Pan Q (2017) Histone methyltransferase SETD2 modulates alternative splicing to inhibit intestinal tumorigenesis. J Clin Investig 127(9):3375–3391
Article PubMed PubMed Central Google Scholar
Chen Z, Raghoonundun C, Chen W, Zhang Y, Tang W, Fan X, Shi X (2018) SETD2 indicates favourable prognosis in gastric cancer and suppresses cancer cell proliferation, migration, and invasion. Biochem Biophys Res Commun 498(3):579–585
Article CAS PubMed Google Scholar
Liu M, Rao H, Liu J, Li X, Feng W, Gui L, Tang H, Xu J, Gao W-Q, Li L (2021) The histone methyltransferase SETD2 modulates oxidative stress to attenuate experimental colitis. Redox Biol 43:102004
Article CAS PubMed PubMed Central Google Scholar
Xu S, Zhu W, Shao M, Zhang F, Guo J, Xu H, Jiang J, Ma X, Xia X, Zhi X (2018) Ecto-5′-nucleotidase (CD73) attenuates inflammation after spinal cord injury by promoting macrophages/microglia M2 polarization in mice. J Neuroinflamm 15(1):1–14
O’Reilly ME, Kajani S, Ralston JC, Lenighan YM, Roche HM, McGillicuddy FC (2019) Nutritionally derived metabolic cues typical of the obese microenvironment increase cholesterol efflux capacity of adipose tissue macrophages. Mol Nutr Food Res 63(2):1800713
Xia L, Sun J, Xie S, Chi C, Zhu Y, Pan J, Dong B, Huang Y, Xia W, Sha J (2020) PRKAR2B-HIF-1α loop promotes aerobic glycolysis and tumour growth in prostate cancer. Cell Prolif 53(11):e12918
Article CAS PubMed PubMed Central Google Scholar
Cai T, Ke Q, Fang Y, Wen P, Chen H, Yuan Q, Luo J, Zhang Y, Sun Q, Lv Y (2020) Sodium–glucose cotransporter 2 inhibition suppresses HIF-1α-mediated metabolic switch from lipid oxidation to glycolysis in kidney tubule cells of diabetic mice. Cell Death Dis 11(5):1–17
Fitzpatrick SF, Tambuwala MM, Bruning U, Schaible B, Scholz CC, Byrne A, O’Connor A, Gallagher WM, Lenihan CR, Garvey JF (2011) An intact canonical NF-κB pathway is required for inflammatory gene expression in response to hypoxia. J Immunol 186(2):1091–1096
Article CAS PubMed Google Scholar
Niu N, Shen X, Zhang L, Chen Y, Lu P, Yang W, Liu M, Shi J, Xu D, Tang Y, Yang X, Weng Y, Zhao X, Wu LM, Sun Y, Xue J (2023) Tumor cell-intrinsic SETD2 deficiency reprograms neutrophils to foster immune escape in pancreatic tumorigenesis. Adv Sci (Weinh) 10(2):e2202937
Lu Y, Rong J, Lai Y, Tao L, Yuan X, Shu X (2020) The degree of helicobacter pylori infection affects the state of macrophage polarization through crosstalk between ROS and HIF-1α. Oxid Med Cell Longev 2020:5281795
Article PubMed PubMed Central Google Scholar
Richmond A (2002) Nf-kappa B, chemokine gene transcription and tumour growth. Nat Rev Immunol 2(9):664–674
Article CAS PubMed PubMed Central Google Scholar
Zhang ZH, Yin DZ, Pang XS, Wang ZC (2015) Effects of HIF prolyl-hydroxylase-2 gene silencing on HCG-induced vascular endothelial growth factor expression in luteal cells. Genet Mol Res 14(4):16744–16755
Article CAS PubMed Google Scholar
Bae WJ, Shin MR, Kang SK, Zhang J, Kim JY, Lee SC, Kim EC (2015) HIF-2 inhibition supresses inflammatory responses and osteoclastic differentiation in human periodontal ligament cells. J Cell Biochem 116(7):1241–1255
Comments (0)