Teng-Fu Hsieh, Division of Nephrology, Department of Internal Medicine, China Medical University
Hung-Lin Chen, Big Data Center, China Medical University Hospital, Taichung, Taiwan
Ying-Fang Hsia, Big Data Center, China Medical University Hospital, Taichung, Taiwan
Che-Chen Lin, Big Data Center, China Medical University Hospital, Taichung, Taiwan
Hsiu-Yin Chiang, Big Data Center, China Medical University Hospital, Taichung, Taiwan
Min-Yen Wu, Big Data Center, China Medical University Hospital, Taichung, Taiwan
Sheng-Hsuan Chen, Big Data Center, China Medical University Hospital, Taichung, Taiwan
Po-Fan Hsieh, Department of Urology, China Medical University Hospital, Taichung, Taiwan
Hsi-Chin Wu, Department of Urology, China Medical University Hospital, Taichung, Taiwan
Han Chang, Department of Pathology, China Medical University Hospital, Taichung, Taiwan
Chin-Chi Kuo, Division of Nephrology, Department of Internal Medicine, China Medical University Hospital, Taichung, TaiwanFollow

Background Testing for prostate-specific antigen (PSA) is often recommended for men with a potential risk of prostate cancer (PCa) before requiring advanced examination. However, the best PSA cutoff value remains controversial. Object We compared the predictive performance of age-specific percentile-based PSA thresholds with a conventional cutoff of >4 ng/mL for the risk of PCa. Methods We included men who received PSA measurements between 2003 and 2017 in a medical center in Taiwan. Logistic regression modeling was used to assess the association between age-specific percentile-based PSA thresholds and PCa risk in age subgroups. We further applied C-statistic and decision curve analysis to compare the predictive performance of age-specific percentile-based PSA with that of a conventional cutoff PSA. Results We identified 626 patients with PCa and 40836 patients without PCa. The slope of PSA in patients > 60-year-old was almost 3 times that of those70-year-old: 5.84 ng/mL) were comparable to those observed based on the conventional cutoff in all age groups. However, the discrimination performance of the 75th percentile PSA cutoff was better than that of the conventional cutoff among patients aged

Hsieh, Teng-Fu; Chen, Hung-Lin; Hsia, Ying-Fang; Lin, Che-Chen; Chiang, Hsiu-Yin; Wu, Min-Yen; Chen, Sheng-Hsuan; Hsieh, Po-Fan; Wu, Hsi-Chin; Chang, Han; and Kuo, Chin-Chi (2023) "Age-Specific Percentile-based Prostate-Specific Antigen Cutoff Values Predict the Risk of Prostate Cancer: a single hospital observation," BioMedicine: Vol. 13 : Iss. 3 , Article 2.
DOI: 10.37796/2211-8039.1415