Modeling Approach with Therapeutic Drug Monitoring Data to Describe Time Course of Clozapine Exposure and Positive and Negative Syndrome Scale Scores

*Department of Pharmacology, College of Medicine, Kangwon National University, Chuncheon, Republic of Korea;

†Biomedical Research Institute, Kangwon National University Hospital, Chuncheon, Republic of Korea;

‡Department of Neuropsychiatry, Seoul National University Bundang Hospital, Seongnam, Republic of Korea;

§Center for Clinical Pharmacology and Biomedical Research Institute, Jeonbuk National University Hospital, Jeonju, Republic of Korea;

¶Department of Pharmacology, School of Medicine, Jeonbuk National University, Jeonju, Republic of Korea;

‖Department of Clinical Pharmacology and Therapeutics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea;

**Department of Brain & Cognitive Sciences, Seoul National University College of Natural Sciences, Seoul, Republic of Korea; and

††Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea.

Correspondence: Euitae Kim, MD, PhD, Department of Neuropsychiatry, Seoul National University Bundang Hospital, 82 Gumi-ro 173 Beon-gil, Bundang-gu, Seongnam 13620, Republic of Korea (e-mail: [email protected]).

Supported by the National Research Foundation of Korea (NRF) grant funded by the Korean Government (Ministry of Science and ICT [MSIT]) (NRF-2018R1C1B6006020). In addition, this study was supported by a 2020 Research Grant from Kangwon National University.

The authors declare no conflict of interest.

Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Web site (www.drug-monitoring.com).

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