Clinical Research in Stroke

Abderrakib A.a· Ligot N.a· Torcida N.a· Sadeghi Meibodi N.b· Naeije G.a

Author affiliations

aNeurology Department, Université Libre de Bruxelles – Cliniques Universitaires de Bruxelles – Hôpital Erasme, Bruxelles, Belgium
bRadiology Department, Université Libre de Bruxelles – Cliniques Universitaires de Bruxelles – Hôpital Erasme, Bruxelles, Belgium

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Article / Publication Details

First-Page Preview

Received: October 15, 2022
Accepted: December 02, 2022
Published online: January 30, 2023

Number of Print Pages: 8
Number of Figures: 3
Number of Tables: 4

ISSN: 1015-9770 (Print)
eISSN: 1421-9786 (Online)

For additional information: https://www.karger.com/CED

Abstract

Introduction: Initial NIHSS in anterior large vessel occlusion (LVO) correlates partially with the hypoperfusion volume. We aimed at assessing the contribution of crossed cerebellar diaschisis (CCD) from the hypoperfused territory on LVO initial clinical deficit. Methods: CCD was retrospectively identified by brain CT perfusion imaging (CTP) in patients with anterior LVO treated by mechanical thrombectomy from January 2017 to July 2021. CCD was defined by CTP parameter alteration in the contralateral cerebellar hemisphere to the LVO. NIHSS, clinical/perfusion variables, and CCD were included in regression models to assess their interrelationships. Results: 206 patients were included. CCD was present in 90 patients (69%). NIHSS scores were higher on admission and at stroke discharge among patients with CCD (17.90 ± 6.1 vs. 11.4 ± 8.4, p < 0.001; 9.6 ± 7.7 vs. 6.6 ± 7.9, p = 0.049; respectively). Patients with a CCD had higher stroke volumes (118.2 ± 60.3 vs. 69.3 ± 59.7, p < 0.001) and lower rate of known atrial fibrillation (22% vs. 41%, p = 0.021). On multivariable logistic regression, CCD independently worsened the initial NIHSS (OR 4.85 [2.37–7.33]; p < 0.001). Conclusion: CCD is found in 69% of LVO on admission CTP, correlates with stroke volumes, and independently worsens initial NIHSS.

© 2023 S. Karger AG, Basel

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First-Page Preview

Received: October 15, 2022
Accepted: December 02, 2022
Published online: January 30, 2023

Number of Print Pages: 8
Number of Figures: 3
Number of Tables: 4

ISSN: 1015-9770 (Print)
eISSN: 1421-9786 (Online)

For additional information: https://www.karger.com/CED

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