Seoudy A.K. · Schlicht K. · Kulle A. · Demetrowitsch T. · Beckmann A. · Geisler C. · Türk K. · Rohmann N. · Hartmann K. · Brandes J. · Schulte D.M. · Schreiber S. · Schwarz K. · Holterhus P.-M. · Laudes M.

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Article / Publication Details Abstract

Introduction The present study aimed to prove the metyrapone short test in a day clinic to be suitable for examining the integrity of the hypothalamic-pituitary-adrenal (HPA) axis in patients with suspected secondary and tertiary adrenal insufficiency and to identify novel effector molecules in acute stress response. Methods 44 patients were prospectively enrolled. Based on stimulated 11-deoxycortisol levels, patients were divided into a physiological (11-deoxycortisol ≥70 µg/l) and a pathological (11-deoxycortisol

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