Ocular Oncology and Pathology

Gurayah A.A. · Peters V.A. · Jin W. · Kalahasty K. · Kwon D. · Zhao W. · Patel N.V. · Markoe A.M. · Correa Z.M. · Studenski M.T. · Harbour J.W. · Samuels S.E.

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Article / Publication Details Abstract

Introduction: Iodine-125 brachytherapy is an effective eye-sparing treatment for uveal melanoma. Previous work has shown that uveal melanomas cluster into distinct molecular classes based on gene expression profiles—discriminating low-grade from high-grade tumors. Our objective was to identify clinical and molecular predictors of local recurrence (LR) and progression-free survival (PFS). Methods: We constructed a retrospective database of uveal melanoma patients from the University of Miami’s electronic medical records that were treated between 8/1/2012-5/1/2019, with either COMS-style or Eye Physics plaque. Data on tumor characteristics, pre-treatment retinal complications, post-plaque treatments, LR and PFS were collected. Univariate and multivariate Cox models for cumulative incidence of LR and PFS were conducted using SAS version 9.4. Results: We identified 262 patients, with a median follow-up time of 33.5 months. 19 patients (7.3%) had local recurrence and 56 patients (21.4%) were classified as PFS. We found that ocular melanocytosis (HR = 5.55, p

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