Sorting Through the Extensive and Confusing Roles of Sortilin in Metabolic Disease

Petersen C.M. Nielsen M.S. Nykjaer A. Jacobsen L. Tommerup N. Rasmussen H.H. et al.

Molecular identification of a novel candidate sorting receptor purified from human brain by receptor-associated protein affinity chromatography.

J Biol Chem. 272: 3599-3605Bu G. Geuze H.J. Strous G.J. Schwartz A.L.

39 kDa receptor-associated protein is an ER resident protein and molecular chaperone for LDL receptor-related protein.

The EMBO journal. 14: 2269-2280Sarti M. Farquhar M.G. Orlando R.A.

The receptor-associated protein (RAP) interacts with several resident proteins of the endoplasmic reticulum including a glycoprotein related to actin.

Exp Cell Res. 260: 199-207Willnow T.E. Armstrong S.A. Hammer R.E. Herz J.

Functional expression of low density lipoprotein receptor-related protein is controlled by receptor-associated protein in vivo.

Proc Natl Acad Sci U S A. 92: 4537-4541Willnow T.E. Rohlmann A. Horton J. Otani H. Braun J.R. Hammer R.E. et al.

RAP, a specialized chaperone, prevents ligand-induced ER retention and degradation of LDL receptor-related endocytic receptors.

The EMBO journal. 15: 2632-2639Lefrancois S. Zeng J. Hassan A.J. Canuel M. Morales C.R.

The lysosomal trafficking of sphingolipid activator proteins (SAPs) is mediated by sortilin.

The EMBO journal. 22: 6430-6437

The lysosomal trafficking of acid sphingomyelinase is mediated by sortilin and mannose 6-phosphate receptor.

Traffic. 7: 889-902Canuel M. Korkidakis A. Konnyu K. Morales C.R.

Sortilin mediates the lysosomal targeting of cathepsins D and H.

Biochem Biophys Res Commun. 373: 292-297Strong A. Ding Q.R. Edmondson A.C. Millar J.S. Sachs K.V. Li X.Y. et al.

Hepatic sortilin regulates both apolipoprotein B secretion and LDL catabolism.

Journal of Clinical Investigation. 122: 2807-2816Evans S.F. Irmady K. Ostrow K. Kim T. Nykjaer A. Saftig P. et al.

Neuronal brain-derived neurotrophic factor is synthesized in excess, with levels regulated by sortilin-mediated trafficking and lysosomal degradation.

J Biol Chem. 286: 29556-29567Nielsen M.S. Jacobsen C. Olivecrona G. Gliemann J. Petersen C.M.

Sortilin/neurotensin receptor-3 binds and mediates degradation of lipoprotein lipase.

J Biol Chem. 274: 8832-8836Lv Y. Yang J. Gao A. Sun S. Zheng X. Chen X. et al.

Sortilin promotes macrophage cholesterol accumulation and aortic atherosclerosis through lysosomal degradation of ATP-binding cassette transporter A1 protein.

Acta Biochim Biophys Sin (Shanghai). 51: 471-483Li J. Wang Y. Matye D.J. Chavan H. Krishnamurthy P. Li F. et al.

Sortilin 1 Modulates Hepatic Cholesterol Lipotoxicity in Mice via Functional Interaction with Liver Carboxylesterase 1.

J Biol Chem. 292: 146-160Kathiresan S. Melander O. Guiducci C. Surti A. Burtt N.P. Rieder M.J. et al.

Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans.

Nat Genet. 40: 189-197Willer C.J. Sanna S. Jackson A.U. Scuteri A. Bonnycastle L.L. Clarke R. et al.

Newly identified loci that influence lipid concentrations and risk of coronary artery disease.

Nat Genet. 40: 161-169Sandhu M.S. Waterworth D.M. Debenham S.L. Wheeler E. Papadakis K. Zhao J.H. et al.

LDL-cholesterol concentrations: a genome-wide association study.

Lancet. 371: 483-491Wallace C. Newhouse S.J. Braund P. Zhang F. Tobin M. Falchi M. et al.

Genome-wide association study identifies genes for biomarkers of cardiovascular disease: serum urate and dyslipidemia.

American journal of human genetics. 82: 139-149Samani N.J. Erdmann J. Hall A.S. Hengstenberg C. Mangino M. Mayer B. et al.

Genomewide association analysis of coronary artery disease.

N Engl J Med. 357: 443-453Musunuru K. Strong A. Frank-Kamenetsky M. Lee N.E. Ahfeldt T. Sachs K.V. et al.

From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus.

Nature. 466: 714-719Kjolby M. Andersen O.M. Breiderhoff T. Fjorback A.W. Pedersen K.M. Madsen P. et al.

Sort1, encoded by the cardiovascular risk locus 1p13.3, is a regulator of hepatic lipoprotein export.

Cell Metab. 12: 213-223

VPS10P Domain Receptors: Sorting Out Brain Health and Disease.

Trends in neurosciences. 43: 870-885Al-Yozbaki M. Acha-Sagredo A. George A. Liloglou T. Wilson C.M.

Balancing neurotrophin pathway and sortilin function: Its role in human disease.

Biochim Biophys Acta Rev Cancer. 1874188429Glerup S. Nykjaer A. Vaegter C.B.

Sortilins in neurotrophic factor signaling.

Handb Exp Pharmacol. 220: 165-189Carlo A.S. Nykjaer A. Willnow T.E.

Sorting receptor sortilin-a culprit in cardiovascular and neurological diseases.

J Mol Med (Berl). 92: 905-911

The Vps10p-domain receptor family.

Cell Mol Life Sci. 66: 2677-2689Willnow T.E. Petersen C.M. Nykjaer A.

VPS10P-domain receptors - regulators of neuronal viability and function.

Nature reviews Neuroscience. 9: 899-909Quistgaard E.M. Madsen P. Groftehauge M.K. Nissen P. Petersen C.M. Thirup S.S.

Ligands bind to Sortilin in the tunnel of a ten-bladed beta-propeller domain.

Nat Struct Mol Biol. 16: 96-98Xu S.Y. Zhang Q.L. Zhang Q. Wan L. Jiang J. Tu T. et al.

Regional and Cellular Mapping of Sortilin Immunoreactivity in Adult Human Brain.

Front Neuroanat. 13: 31Boggild S. Molgaard S. Glerup S. Nyengaard J.R.

Spatiotemporal patterns of sortilin and SorCS2 localization during organ development.

BMC cell biology. 17: 8Hermans-Borgmeyer I. Hermey G. Nykjaer A. Schaller C.

Expression of the 100-kDa neurotensin receptor sortilin during mouse embryonal development.

Brain research Molecular brain research. 65: 216-219Boggild S. Molgaard S. Glerup S. Nyengaard J.R.

Highly segregated localization of the functionally related vps10p receptors sortilin and SorCS2 during neurodevelopment.

J Comp Neurol. 526: 1267-1286Patel K.M. Strong A. Tohyama J. Jin X. Morales C.R. Billheimer J. et al.

Macrophage sortilin promotes LDL uptake, foam cell formation, and atherosclerosis.

Circ Res. 116: 789-796Mortensen M.B. Kjolby M. Gunnersen S. Larsen J.V. Palmfeldt J. Falk E. et al.

Targeting sortilin in immune cells reduces proinflammatory cytokines and atherosclerosis.

J Clin Invest. 124: 5317-5322Herda S. Raczkowski F. Mittrücker H.-W. Willimsky G. Gerlach K. Kühl A.A. et al.

The Sorting Receptor Sortilin Exhibits a Dual Function in Exocytic Trafficking of Interferon-γ and Granzyme A in T Cells.

Immunity. 37 ()Fauchais A.L. Lalloue F. Lise M.C. Boumediene A. Preud'homme J.L. Vidal E. et al.

Role of endogenous brain-derived neurotrophic factor and sortilin in B cell survival.

J Immunol. 181: 3027-3038Schadt E.E. Molony C. Chudin E. Hao K. Yang X. Lum P.Y. et al.

Mapping the genetic architecture of gene expression in human liver.

PLoS Biol. 6: e107Linsel-Nitschke P. Heeren J. Aherrahrou Z. Bruse P. Gieger C. Illig T. et al.

Genetic variation at chromosome 1p13.3 affects sortilin mRNA expression, cellular LDL-uptake and serum LDL levels which translates to the risk of coronary artery disease.

Atherosclerosis. 208: 183-189Kaddai V. Jager J. Gonzalez T. Najem-Lendom R. Bonnafous S. Tran A. et al.

Involvement of TNF-α in abnormal adipocyte and muscle sortilin expression in obese mice and humans.

Diabetologia. 52: 932-940Bi L. Chiang J.Y. Ding W.X. Dunn W. Roberts B. Li T.

Saturated fatty acids activate ERK signaling to downregulate hepatic sortilin 1 in obese and diabetic mice.

Journal of lipid research. 54: 2754-2762Ai D. Baez J.M. Jiang H. Conlon D.M. Hernandez-Ono A. Frank-Kamenetsky M. et al.

Activation of ER stress and mTORC1 suppresses hepatic sortilin-1 levels in obese mice.

J Clin Invest. 122: 1677-1687Pirault J. Polyzos K.A. Petri M.H. Ketelhuth D.F.J. Back M. Hansson G.K.

The inflammatory cytokine interferon-gamma inhibits sortilin-1 expression in hepatocytes via the JAK/STAT pathway.

European journal of immunology. 47: 1918-1924Klingenberg R. Gerdes N. Badeau R.M. Gistera A. Strodthoff D. Ketelhuth D.F. et al.

Depletion of FOXP3+ regulatory T cells promotes hypercholesterolemia and atherosclerosis.

J Clin Invest. 123: 1323-1334Prudencio M. Jansen-West K.R. Lee W.C. Gendron T.F. Zhang Y.-J. Xu Y.-F. et al.

Misregulation of human sortilin splicing leads to the generation of a nonfunctional progranulin receptor.

Proceedings of the National Academy of Sciences. 109: 21510-21515Polymenidou M. Lagier-Tourenne C. Hutt K.R. Huelga S.C. Moran J. Liang T.Y. et al.

Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43.

Nature neuroscience. 14: 459-468Tann J.Y. Wong L.W. Sajikumar S. Ibanez C.F.

Abnormal TDP-43 function impairs activity-dependent BDNF secretion, synaptic plasticity, and cognitive behavior through altered Sortilin splicing.

The EMBO journal. 38Mohagheghi F. Prudencio M. Stuani C. Cook C. Jansen-West K. Dickson D.W. et al.

TDP-43 functions within a network of hnRNP proteins to inhibit the production of a truncated human SORT1 receptor.

Human molecular genetics. 25: 534-545Yabe-Wada T. Philpott C.C. Onai N.

PCBP2 post-transcriptionally regulates sortilin expression by binding to a C-rich element in its 3' UTR.

FEBS Open Bio. Yabe-Wada T. Matsuba S. Takeda K. Sato T. Suyama M. Ohkawa Y. et al.

TLR signals posttranscriptionally regulate the cytokine trafficking mediator sortilin.

Sci Rep. 626566Kawashima K.I. Ishiuchi Y. Konnai M. Komatsu S. Sato H. Kawaguchi H. et al.

Glucose deprivation regulates the progranulin-sortilin axis in PC12 cells.

FEBS Open Bio. 7: 149-159Ariga M. Yoneyama Y. Fukushima T. Ishiuchi Y. Ishii T. Sato H. et al.

Glucose deprivation attenuates sortilin levels in skeletal muscle cells.

Endocr J. 64: 255-268Zhang Z. Jiang W. Yang H. Lin Q. Qin X.

The miR-182/SORT1 axis regulates vascular smooth muscle cell calcification in vitro and in vivo.

Exp Cell Res. 362: 324-331Zhang T. Shi H. Liu N. Tian J. Zhao X. Steer C.J. et al.

Activation of microRNA-378a-3p biogenesis promotes hepatic secretion of VLDL and hyperlipidemia by modulating ApoB100-Sortilin1 axis.

Theranostics. 10: 3952-3966McCormick P.J. Dumaresq-Doiron K. Pluviose A.S. Pichette V. Tosato G. Lefrancois S.

Palmitoylation controls recycling in lysosomal sorting and trafficking.

Traffic. 9: 1984-1997Dumaresq-Doiron K. Jules F. Lefrancois S.

Sortilin turnover is mediated by ubiquitination.

Biochem Biophys Res Commun. 433: 90-95Chen C. Li J. Matye D.J. Wang Y. Li T.

Hepatocyte sortilin 1 knockout and treatment with a sortilin 1 inhibitor reduced plasma cholesterol in Western diet-fed mice.

Journal of lipid research. 60: 539-549Li J. Bi L. Hulke M. Li T.

Fish oil and fenofibrate prevented phosphorylation-dependent hepatic sortilin 1 degradation in Western diet-fed mice.

J Biol Chem. 289: 22437-22449Li J. Chen C. Li Y. Matye D.J. Wang Y. Ding W.X. et al.

Inhibition of insulin/PI3K/AKT signaling decreases adipose Sortilin 1 in mice and 3T3-L1 adipocytes.

Biochim Biophys Acta Mol Basis Dis. 1863: 2924-2933

Insulin resistance induces posttranslational hepatic sortilin 1 degradation in mice.

J Biol Chem. 290: 11526-11536Li J. Matye D.J. Wang Y. Li T.

Sortilin 1 knockout alters basal adipose glucose metabolism but not diet-induced obesity in mice.

FEBS Lett. 591: 1018-1028Zhang Q. Lin W. Tian L. Di B. Yu J. Niu X. et al.

Oxidized low-density lipoprotein activates extracellular signal-regulated kinase signaling to downregulate sortilin expression in liver sinusoidal endothelial cells.

Journal of gastroenterology and hepatology. Tsuchiya Y. Hatakeyama H. Emoto N. Wagatsuma F. Matsushita S. Kanzaki M.

Palmitate-induced down-regulation of sortilin and impaired GLUT4 trafficking in C2C12 myotubes.

J Biol Chem. 285: 34371-34381Jun J.Y. Ma Z. Pyla R. Segar L.

Leptin treatment inhibits the progression of atherosclerosis by attenuating hypercholesterolemia in type 1 diabetic Ins2(+/Akita):apoE(-/-) mice.

Atherosclerosis. 225: 341-347Marcusson E.G. Horazdovsky B.F. Cereghino J.L. Gharakhanian E. Emr S.D.

The sorting receptor for yeast vacuolar carboxypeptidase Y is encoded by the VPS10 gene.

Cell. 77: 579-586

Vps10p cycles between the late-Golgi and prevacuolar compartments in its function as the sorting receptor for multiple yeast vacuolar hydrolases.

The Journal of cell biology. 133: 529-541Westphal V. Marcusson E.G. Winther J.R. Emr S.D. van den Hazel H.B.

Multiple pathways for vacuolar sorting of yeast proteinase A.

J Biol Chem. 271: 11865-11870

Structure and function of the mannose 6-phosphate/insulinlike growth factor II receptors.

Annual review of biochemistry. 61: 307-330

The biogenesis of lysosomes.

Annual review of cell biology. 5: 483-525Nielsen M.S. Madsen P. Christensen E.I. Nykjaer A. Gliemann J. Kasper D. et al.

The sortilin cytoplasmic tail conveys Golgi-endosome transport and binds the VHS domain of the GGA2 sorting protein.

The EMBO journal. 20: 2180-2190Takatsu H. Katoh Y. Shiba Y. Nakayama K.

Golgi-localizing, gamma-adaptin ear homology domain, ADP-ribosylation factor-binding (GGA) proteins interact with acidic dileucine sequences within the cytoplasmic domains of sorting receptors through their Vps27p/Hrs/STAM (VHS) domains.

J Biol Chem. 276: 28541-28545

Cargo-selective endosomal sorting for retrieval to the Golgi requires retromer.

The Journal of cell biology. 165: 111-122Canuel M. Lefrancois S. Zeng J. Morales C.R.

AP-1 and retromer play opposite roles in the trafficking of sortilin between the Golgi apparatus and the lysosomes.

Biochem Biophys Res Commun. 366: 724-730Mari M. Bujny M.V. Zeuschner D. Geerts W.J. Griffith J. Petersen C.M. et al.

SNX1 defines an early endosomal recycling exit for sortilin and mannose 6-phosphate receptors.

Traffic. 9: 380-393Kim E. Lee Y. Lee H.J. Kim J.S. Song B.S. Huh J.W. et al.

Implication of mouse Vps26b-Vps29-Vps35 retromer complex in sortilin trafficking.

Biochem Biophys Res Commun. 403: 167-171Zeng J. Hassan A.J. Morales C.R.

Study of the mouse sortilin gene: Effects of its transient silencing by RNA interference in TM4 Sertoli cells.

Mol Reprod Dev. 68: 469-475Hassan A.J. Zeng J. Ni X. Morales C.R.

The trafficking of prosaposin (SGP-1) and GM2AP to the lysosomes of TM4 Sertoli cells is mediated by sortilin and monomeric adaptor proteins.

Mol Reprod Dev. 68: 476-483Lefrancois S. Canuel M. Zeng J. Morales C.R.

Inactivation of sortilin (a novel lysosomal sorting receptor) by dominant negative competition and RNA interference.

Biol Proced Online. 7: 17-25Canuel M. Bhattacharyya N. Balbis A. Yuan L. Morales C.R.

Sortilin and prosaposin localize to detergent-resistant membrane microdomains.

Exp Cell Res. 315: 240-247Zeng J. Racicott J. Morales C.R.

The inactivation of the sortilin gene leads to a partial disruption of prosaposin trafficking to the lysosomes.

Experimental cell research. 315: 3112-3124

A stretch of 17 amino acids in the prosaposin C terminus is critical for its binding to sortilin and targeting to lysosomes.

J Histochem Cytochem. 58: 287-300Wahe A. Kasmapour B. Schmaderer C. Liebl D. Sandhoff K. Nykjaer A. et al.

Golgi-to-phagosome transport of acid sphingomyelinase and prosaposin is mediated by sortilin.

Journal of cell science. 123: 2502-2511Jin S. Yi F. Zhang F. Poklis J.L. Li P.L.

Lysosomal targeting and trafficking of acid sphingomyelinase to lipid raft platforms in coronary endothelial cells.

Arterioscler Thromb Vasc Biol. 28: 2056-2062Bao J.X. Jin S. Zhang F. Wang Z.C. Li N. Li P.L.

Activation of membrane NADPH oxidase associated with lysosome-targeted acid sphingomyelinase in coronary endothelial cells.

Antioxid Redox Signal. 12: 703-712

Sortilin is essential and sufficient for the formation of Glut4 storage vesicles in 3T3-L1 adipocytes.

Dev Cell. 9: 99-108Chen Z.Y. Ieraci A. Teng H. Dall H. Meng C.X. Herrera D.G. et al.

Sortilin controls intracellular sorting of brain-derived neurotrophic factor to the regulated secretory pathway.

The Journal of neuroscience : the official journal of the Society for Neuroscience. 25: 6156-6166Morris N.J. Ross S.A. Lane W.S. Moestrup S.K. Petersen C.M. Keller S.R. et al.

Sortilin is the major 110-kDa protein in GLUT4 vesicles from adipocytes.

J Biol Chem. 273: 3582-3587Morinville A. Martin S. Lavallee M. Vincent J.P. Beaudet A. Mazella J.

Internalization and trafficking of neurotensin via NTS3 receptors in HT29 cells.

Int J Biochem Cell Biol. 36: 2153-2168Nilsson S.K. Christensen S. Raarup M.K. Ryan R.O. Nielsen M.S. Olivecrona G.

Endocytosis of apolipoprotein A-V by members of the low density lipoprotein receptor and the VPS10p domain receptor families.

J Biol Chem. 283: 25920-25927Prabakaran T. Nielsen R. Satchell S.C. Mathieson P.W. Feldt-Rasmussen U. Sorensen S.S. et al.

Mannose 6-phosphate receptor and sortilin mediated endocytosis of alpha-galactosidase A in kidney endothelial cells.

PLoS One. 7e39975Wilson C.M. Naves T. Vincent F. Melloni B. Bonnaud F. Lalloue F. et al.

Sortilin mediates the release and transfer of exosomes in concert with two tyrosine kinase receptors.

Journal of cell science. 127: 3983-3997Goettsch C. Hutcheson J.D. Aikawa M. Iwata H. Pham T. Nykjaer A. et al.

Sortilin mediates vascular calcification via its recruitment into extracellular vesicles.

J Clin Invest. 126: 1323-1336Pinet S. Bessette B. Vedrenne N. Lacroix A. Richard L. Jauberteau M.O. et al.

TrkB-containing exosomes promote the transfer of glioblastoma aggressiveness to YKL-40-inactivated glioblastoma cells.

Oncotarget. 7: 50349-50364Itoh S. Mizuno K. Aikawa M. Aikawa E.

Dimerization of sortilin regulates its trafficking to extracellular vesicles.

J Biol Chem. 293: 4532-4544Jacobsen L. Madsen P. Nielsen M.S. Geraerts W.P. Gliemann J. Smit A.B. et al.

The sorLA cytoplasmic domain interacts with GGA1 and -2 and defines minimum requirements for GGA binding.

FEBS Lett. 511: 155-158Cramer J.F. Gustafsen C. Behrens M.A. Oliveira C.L. Pedersen J.S. Madsen P. et al.

GGA autoinhibition revisited.

Traffic. 11: 259-273Baltes J. Larsen J.V. Radhakrishnan K. Geumann C. Kratzke M. Petersen C.M. et al.

sigma1B adaptin regulates adipogenesis by mediating the sorting of sortilin in adipose tissue.

Journal of cell science. 127: 3477-3487Harbour M.E. Breusegem S.Y. Antrobus R. Freeman C. Reid E. Seaman M.N.

The cargo-selective retromer complex is a recruiting hub for protein complexes that regulate endosomal tubule dynamics.

Journal of cell science. 123: 3703-3717Suzuki S.W. Chuang Y.S. Li M. Seaman M.N.J. Emr S.D.

A bipartite sorting signal ensures specificity of retromer complex in membrane protein recycling.

The Journal of cell biology. 218: 2876-2886

Identification of a novel conserved sorting motif required for retromer-mediated endosome-to-TGN retrieval.

Journal of cell science. 120: 2378-2389Cereghino J.L. Marcusson E.G. Emr S.D.

The cytoplasmic tail domain of the vacuolar protein sorting receptor Vps10p and a subset of VPS gene products regulate receptor stability, function, and localization.

Molecular biology of the cell. 6: 1089-1102Mamo A. Jules F. Dumaresq-Doiron K. Costantino S. Lefrancois S.

The role of ceroid lipofuscinosis neuronal protein 5 (CLN5) in endosomal sorting.

Mol Cell Biol. 32: 1855-1866Hirst J. Itzhak D.N. Antrobus R. Borner G.H.H. Robinson M.S.

Role of the AP-5 adaptor protein complex in late endosome-to-Golgi retrieval.

PLoS Biol. 16e2004411Progida C. Nielsen M.S. Koster G. Bucci C. Bakke O.

Dynamics of Rab7b-dependent transport of sorting receptors.

Traffic. 13: 1273-1285Larkin H. Costantino S. Seaman M.N. Lavoie C.

Calnuc Function in Endosomal Sorting of Lysosomal Receptors.

Traffic. 17: 416-432Chen H.J. Yuan J. Lobel P.

Systematic mutational analysis of the cation-independent mannose 6-phosphate/insulin-like growth factor II receptor cytoplasmic domain. An acidic cluster containing a key aspartate is important for function in lysosomal enzyme sorting.

J Biol Chem. 272: 7003-7012Molloy S.S. Anderson E.D. Jean F. Thomas G.

Bi-cycling the furin pathway: from TGN localization to pathogen activation and embryogenesis.

Trends in cell biology. 9: 28-35Scott G.K. Fei H. Thomas L. Medigeshi G.R. Thomas G.

A PACS-1, GGA3 and CK2 complex regulates CI-MPR trafficking.

The EMBO journal. 25: 4423-4435Pallesen L.T. Gustafsen C. Cramer J.F. Petersen S.V. Thirup S.S. Madsen P. et al.

PAK Kinases Target Sortilin and Modulate Its Sorting.

Mol Cell Biol. 40

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