Brief Reports Authors: Wasanthi Wickramasinghe , University of Colombo, LK About Wasanthi Faculty of Medicine X close Revathi Raj, Apollo Children Hospital, IN X close Shama Goonatillake, Asiri Surgical Hospital, LK X close Anuja Abayadeera, University of Colombo, LK About Anuja Faculty of Medicine X close Malik Samarasinghe, University of Colombo, LK About Malik Faculty of Medicine X close Jeewaka Galhenage, National Blood Transfusion Services, LK X close Pavithra Aarewatte, Lady Ridgeway Hospital for Children, LK X close Devan Mendis, Lady Ridgeway Hospital for Children, LK X close Chandima Thevarapperuma, Lady Ridgeway Hospital for Children, LK X close Ruwangi Dissanayake, University of Colombo, LK About Ruwangi Faculty of Medicine X close Lallindra Gooneratne University of Colombo, LK About Lallindra Faculty of Medicine X close Abstract

Bone marrow failure (BMF) in children can be idiopathic (70-80%) or inherited. Haematopoietic stem cell transplantation (HSCT) is the only cure for both causes.

 

Allogeneic HSCT requires a suitable donor. Many children will not have a HLA matched sibling or unrelated donor. A haploidentical donor is available for all children as eaazch parent will have at minimum a 50% HLA match.

 

This report of a 7-year old girl with BMF treated with a haplo-HSCT, the first in Sri Lanka, highlights the importance of developing a haploidentical HSCT programme as a potential cure for a disease with a dismal outcome.

DOI: https://doi.org/10.4038/cmj.v67i1.9554 How to Cite: Wickramasinghe, W., Raj, R., Goonatillake, S., Abayadeera, A., Samarasinghe, M., Galhenage, J., Aarewatte, P., Mendis, D., Thevarapperuma, C., Dissanayake, R. and Gooneratne, L., 2022. A report of haploidentical allogeneic haematopoietic stem cell transplantation for inherited bone marrow failure in Sri Lanka. Ceylon Medical Journal, 67(1), pp.17–19. DOI: http://doi.org/10.4038/cmj.v67i1.9554

Published on 04 May 2022.

Peer Reviewed

Downloads PDF (EN)