Research Article
Free Access
Alotaibi R.N. ·
Howe B.J. · Moreno Uribe L.M. · Sanchez C. · Deleyiannis F.W.B. · Padilla C. ·
Poletta F.A. · Orioli I.M. · Buxó C.J. · Wehby G.L. ·
Vieira A.R. · Murray J. · Valencia-Ramírez C. · Restrepo Muñeton C.P. · Long R.E. · Shaffer J.R. · Reis S.E. · Weinberg S.M. · Neiswanger K. · McNeil D.W. · Marazita M.L.
Abstract
Enamel hypoplasia causes reduction in the thickness of affected enamel and is one of the most common dental anomalies. This defect is caused by environmental and/or genetic factors that interfere with tooth formation, emphasizing the importance of investigating enamel hypoplasia on an epidemiological and genetic level. A genome-wide association of enamel hypoplasia was performed in multiple cohorts, overall comprising 7,159 individuals ranging in age from 7-82 years. Mixed-models were used to test for genetic association while simultaneously accounting for relatedness and genetic population structure. Meta-analysis was then performed.
More than 5 million single-nucleotide polymorphisms were tested in individual cohorts. Analyses of the individual cohorts and meta-analysis identified association signals close to genome-wide significance (P
S. Karger AG, Basel
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