Corresponding Author

Translational Medical Sciences, University of Nottingham

NIHR Biomedical Research Centre, Nottingham University Hospitals NHS Trust and University of Nottingham

National Disease Registration Service, NHS Digital

Correspondence: Colin J Crooks, Nottingham Digestive Diseases Centre, School of Medicine, University of Nottingham. (e-mail: colin.crooks@nottingham.ac.uk)

Dr Mark Bishton, Department of Haematology, Nottingham University Hospitals NHS Trust, Hucknall Road, Nottingham, UK, NG5 1PB. (e-mail: mark.bishton@nuh.nhs.uk)