1. Akinyemiju, T, Abera, S, et al., Global Burden of Disease Liver Cancer, C. The burden of primary liver cancer and underlying etiologies from 1990 to 2015 at the global, regional, and national level: results from the global burden of disease study 2015. JAMA Oncol. 2017;3(12):1683-1691.
Google Scholar | Crossref | Medline2. Bruix, J, Reig, M, Sherman, M. Evidence-based diagnosis, staging, and treatment of patients with hepatocellular carcinoma. Gastroenterology. 2016;150(4):835-853.
Google Scholar | Crossref | Medline3. Long, J, Wang, A, Bai, Y, et al. Development and validation of a TP53-associated immune prognostic model for hepatocellular carcinoma. EBioMedicine. 2019;42(6):363-374.
Google Scholar | Crossref | Medline4. Zhang, FP, Huang, YP, Luo, WX, et al. Construction of a risk score prognosis model based on hepatocellular carcinoma microenvironment. World J Gastroenterol. 2020;26(2):134-153.
Google Scholar | Crossref | Medline5. Ao, L, Song, X, Li, X, et al. An individualized prognostic signature and multiomics distinction for early stage hepatocellular carcinoma patients with surgical resection. Oncotarget. 2016;7(17):24097-24110.
Google Scholar | Crossref | Medline6. Miyajima, A, Tanaka, M, Itoh, T. Stem/progenitor cells in liver development, homeostasis, regeneration, and reprogramming. Cell Stem Cell. 2014;14(5):561-574.
Google Scholar | Crossref | Medline | ISI7. Reya, T, Morrison, SJ, Clarke, MF, Weissman, IL Stem cells, cancer, and cancer stem cells. Nature. 2001;414(6859):105-111.
Google Scholar | Crossref | Medline | ISI8. Britton, KM, Kirby, JA, Lennard, TW, Meeson, AP Cancer stem cells and side population cells in breast cancer and metastasis. Cancers (Basel). 2011;3(2):2106-2130.
Google Scholar | Crossref | Medline9. Chen, D, Li, Z, Cheng, Q, et al. Genetic alterations and expression of PTEN and its relationship with cancer stem cell markers to investigate pathogenesis and to evaluate prognosis in hepatocellular carcinoma. J Clin Pathol. 2019;72(9):588-596.
Google Scholar | Crossref | Medline10. Noh, CK, Wang, HJ, Kim, CM, et al. EpCAM as a Predictive Marker of Tumor Recurrence and Survival in Patients Who Underwent Surgical Resection for Hepatocellular Carcinoma. Anticancer Res. 2018;38(7):4101-4109.
Google Scholar | Crossref | Medline11. Zhou, L, Zhu, Y. The EpCAM overexpression is associated with clinicopathological significance and prognosis in hepatocellular carcinoma patients: a systematic review and meta-analysis. Int J Surg. 2018;56(15):274-280.
Google Scholar | Crossref | Medline12. Tsuchiya, A, Kamimura, H, Tamura, Y, et al. Hepatocellular carcinoma with progenitor cell features distinguishable by the hepatic stem/progenitor cell marker NCAM. Cancer Lett. 2011;309(1):95-103.
Google Scholar | Crossref | Medline13. Xu, X, Liu, RF, Zhang, X, et al. DLK1 as a potential target against cancer stem/progenitor cells of hepatocellular carcinoma. Mol Cancer Ther. 2012;11(3):629-638.
Google Scholar | Crossref | Medline14. Li, XF, Chen, C, Xiang, DM, et al. Chronic inflammation-elicited liver progenitor cell conversion to liver cancer stem cell with clinical significance. Hepatology. 2017;66(6):1934-1951.
Google Scholar | Crossref | Medline15. Liu, Y, Cao, L, Chen, R, et al. Osteopontin Promotes Hepatic Progenitor Cell Expansion and Tumorigenicity via Activation of beta-Catenin in Mice. Stem Cells. 2015;33(12):3569-3580.
Google Scholar | Crossref | Medline16. Yu, G, Wang, LG, Han, Y, et al. Clusterprofiler: an R package for comparing biological themes among gene clusters. OMICS. 2012;16(5):284-287.
Google Scholar | Crossref | Medline17. Robinson, MD, McCarthy, DJ, Smyth, GK. Edger: a bioconductor package for differential expression analysis of digital gene expression data. Bioinformatics. 2010;26(1):139-140.
Google Scholar | Crossref | Medline | ISI18. Li, N, Li, L, Chen, Y. The Identification of Core Gene Expression Signature in Hepatocellular Carcinoma. Oxid Med Cell Longev. 2018;2018(11):3478305.
Google Scholar | Medline19. Li, B, Chng, WJ. EZH2 abnormalities in lymphoid malignancies: underlying mechanisms and therapeutic implications. J Hematol Oncol. 2019;12(1):118.
Google Scholar | Crossref | Medline20. Ning, X, Shi, Z, Liu, X, et al. DNMT1 and EZH2 mediated methylation silences the microRNA-200b/a/429 gene and promotes tumor progression. Cancer Lett. 2015;359(2):198-205.
Google Scholar | Crossref | Medline21. Xu, X, Gu, J, Ding, X, et al. LINC00978 Promotes the progression of hepatocellular carcinoma by regulating EZH2-mediated silencing of p21 and E-cadherin expression. Cell Death Dis. 2019;10(10):752.
Google Scholar | Crossref | Medline22. Fu, X, Lin, J, Qin, F, et al. LncAPC drives Wnt/beta-catenin activation and liver TIC self-renewal through EZH2 mediated APC transcriptional inhibition. Mol Carcinog. 2018;57(3):408-418.
Google Scholar | Crossref | Medline23. Gorodetska, I, Lukiyanchuk, K, Peitzsch, C, Kozeretska, I, Dubrovska, A BRCA1 and EZH2 cooperate in regulation of prostate cancer stem cell phenotype. Int J Cancer. 2019;145(11):2974-2985.
Google Scholar | Crossref | Medline24. Zhu, P, Wang, Y, Huang, G, et al. lnc-beta-Catm elicits EZH2-dependent beta-catenin stabilization and sustains liver CSC self-renewal. Nat Struct Mol Biol. 2016;23(7):631-639.
Google Scholar | Crossref | Medline25. Arai, M, Yokosuka, O, Fukai, K, et al. Gene expression profiles in liver regeneration with oval cell induction. Biochem Biophys Res Commun. 2004;317(2):370-376.
Google Scholar | Crossref | Medline26. Wang, X, Lopategi, A, Ge, X, et al. Osteopontin induces ductular reaction contributing to liver fibrosis. Gut. 2014;63(11):1805-1818.
Google Scholar | Crossref | Medline