Introduction

This book presents results obtained from the whole mount preparations, radiological, and histological studies of 60 pu/pu and pu/+ mice from late embryo until 3 months of age. Most mice were in the embryo to 6 week age group where vertebral developmental changes are most marked. Although vertebral abnormalities have been identified as due to mutations in the delta-like 3 (Dll3) gene, it is evident that each mouse has differing structural abnormalities. The disorder is analogous to human congenital scoliosis, a common variant of which is spondylocostal dysplasia. The histological studies presented in this book include plastic embedded sections which allow for high level resolution not only of vertebrae, intervertebral discs, and ribs but also of associated spinal cord, nerve roots and ganglia. In addition an overview of embryo and neonatal development in mouse, chick and human vertebrae is provided to better assess how and where deviant pathoanatomy occurs. The book discusses the possible variables involved in creating final deformity beyond the gene abnormality itself.

Keywords

congenital scoliosis human vertebral development morphological gradients in deformity spondylocostal dysplasia rib malformation

Authors and affiliations 1.Department of Orthopedic SurgeryChildren's Hospital BostonBostonUSA About the authors

Frederic Shapiro received his MD degree from the University of Toronto Faculty of Medicine. He completed a residency in orthopedic surgery at the Montreal General Hospital: McGill University, Montreal, Quebec and a research fellowship in orthopedic surgery at Boston Children's Hospital.Frederic Shapiro, MD, Orthopedic Research Laboratory, Children's Hospital, Boston, USA.

Bibliographic information Book Title Disordered Vertebral and Rib Morphology in Pudgy Mice Book Subtitle Structural Relationships to Human Congenital Scoliosis Authors Frederic Shapiro
Series Title Advances in Anatomy, Embryology and Cell Biology Series Abbreviated Title Advs Anatomy DOI https://doi.org/10.1007/978-3-319-43151-2 Copyright Information Springer International Publishing Switzerland 2016 Publisher Name Springer, Cham eBook Packages Medicine Medicine (R0) Softcover ISBN 978-3-319-43149-9 eBook ISBN 978-3-319-43151-2 Series ISSN 0301-5556 Series E-ISSN 2192-7065 Edition Number 1 Number of Pages IX, 123 Number of Illustrations 5 b/w illustrations, 15 illustrations in colour Topics Human Genetics
Animal Anatomy / Morphology / Histology
Animal Models