Effects of melatonin on sleep disturbances in multiple sclerosis: A randomized, controlled pilot study

1. Clark, CM, Fleming, JA, Li, D, et al. Sleep disturbance, depression, and lesion site in patients with multiple sclerosis. Arch Neurol 1992; 49: 641–643. 1992/06/01.
Google Scholar | Crossref | Medline2. Tachibana, N, Howard, RS, Hirsch, NP, et al. Sleep problems in multiple sclerosis. Eur Neurol 1994; 34: 320–323. 1994/01/01.
Google Scholar | Crossref | Medline | ISI3. Caminero, A, Bartolome, M. Sleep disturbances in multiple sclerosis. J Neurol Sci 2011; 309: 86–91. 2011/08/05.
Google Scholar | Crossref | Medline | ISI4. Melamud, L, Golan, D, Luboshitzky, R, et al. Melatonin dysregulation, sleep disturbances and fatigue in multiple sclerosis. J Neurol Sci 2012; 314: 37–40. 2011/12/06.
Google Scholar | Crossref | Medline5. Dijk, DJ, Cajochen, C. Melatonin and the circadian regulation of sleep initiation, consolidation, structure, and the sleep EEG. J Biol Rhythms 1997; 12: 627–635. 1997/12/24.
Google Scholar | SAGE Journals | ISI6. Sanchez-Barcelo, EJ, Rueda, N, Mediavilla, MD, et al. Clinical uses of melatonin in neurological diseases and mental and behavioural disorders. Curr Med Chem 2017; 24: 3851–3878. 2017/07/20.
Google Scholar | Crossref | Medline7. Lunde HM, B, Aae, TF, Indrevag, W, et al. Poor sleep in patients with multiple sclerosis. PLoS One 2012; 7: e49996. 2012/11/21.
Google Scholar | Crossref | Medline8. Farez, MF, Mascanfroni, ID, Mendez-Huergo, SP, et al. Melatonin contributes to the seasonality of multiple sclerosis relapses. Cell 2015; 162: 1338–1352. 2015/09/12.
Google Scholar | Crossref | Medline | ISI9. Dokoohaki, S, Ghareghani, M, Ghanbari, A, et al. Corticosteroid therapy exacerbates the reduction of melatonin in multiple sclerosis. Steroids 2017; 128: 32–36. 2017/10/25.
Google Scholar | Crossref | Medline10. Sandyk, R, Awerbuch, GI. The pineal gland in multiple sclerosis. Int J Neurosci 1991; 61: 61–67. 1991/11/01.
Google Scholar | Crossref | Medline11. Anderson, G, Rodriguez, M. Multiple sclerosis, seizures, and antiepileptics: role of IL-18, IDO, and melatonin. Eur J Neurol 2011; 18: 680–685. 2010/12/02.
Google Scholar | Crossref | Medline12. Adamczyk-Sowa, M, Pierzchala, K, Sowa, P, et al. Influence of melatonin supplementation on serum antioxidative properties and impact of the quality of life in multiple sclerosis patients. J Physiol Pharmacol 2014; 65: 543–550. 2014/09/03.
Google Scholar | Medline13. Buysse, DJ, Reynolds, CF, Monk, TH, et al. The Pittsburgh sleep quality index: a new instrument for psychiatric practice and research. Psychiatry Res 1989; 28: 193–213. 1989/05/01.
Google Scholar | Crossref | Medline | ISI14. Morin, CM, Belleville, G, Belanger, L, et al. The insomnia severity index: psychometric indicators to detect insomnia cases and evaluate treatment response. Sleep 2011; 34: 601–608. 2011/05/03.
Google Scholar | Crossref | Medline | ISI15. Polman, CH, Reingold, SC, Banwell, B, et al. Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald criteria. Ann Neurol 2011; 69: 292–302. 2011/03/10.
Google Scholar | Crossref | Medline | ISI16. Ezeugwu, V, Klaren RE, EAH, et al. Mobility disability and the pattern of accelerometer-derived sedentary and physical activity behaviors in people with multiple sclerosis. Prev Med Rep 2015; 2: 241–246. 2016/02/05.
Google Scholar | Crossref | Medline17. Blackwell, T, Redline, S, Ancoli-Israel, S, et al. Comparison of sleep parameters from actigraphy and polysomnography in older women: the SOF study. Sleep 2008; 31: 283–291. 2008/02/16.
Google Scholar | Crossref | Medline | ISI18. Johns, MW . A new method for measuring daytime sleepiness: the epworth sleepiness scale. Sleep 1991; 14: 540–545. 1991/12/01.
Google Scholar | Crossref | Medline | ISI19. Cella, D, Lai, JS, Nowinski, CJ, et al. Neuro-QOL: brief measures of health-related quality of life for clinical research in neurology. Neurology 2012; 78: 1860–1867. 2012/05/11.
Google Scholar | Crossref | Medline | ISI20. Hobart, JC, Riazi, A, Lamping, DL, et al. Measuring the impact of MS on walking ability: the 12-item MS walking scale (MSWS-12). Neurology 2003; 60: 31–36. 2003/01/15.
Google Scholar | Crossref | Medline | ISI21. Zigmond, AS, Snaith, RP. The hospital anxiety and depression scale. Acta Psychiatr Scand 1983; 67: 361–370. 1983/06/01.
Google Scholar | Crossref | Medline | ISI22. Sateia, MJ, Buysse, DJ, Krystal, AD, et al. Clinical practice guideline for the pharmacologic treatment of chronic insomnia in adults: an American academy of sleep medicine clinical practice guideline. J Clin Sleep Med 2017; 13: 307–349. 2016/12/22.
Google Scholar | Crossref | Medline23. Mehta, L, McNeill, M, Hobart, J, et al. Identifying an important change estimate for the multiple sclerosis walking scale-12 (MSWS-12v1) for interpreting clinical trial results. Mult Scler J Exp Transl Clin 2015; 1: 2055217315596993. 2015/08/05.
Google Scholar | SAGE Journals24. Patel, S, Kon, SSC, Nolan, CM, et al. The epworth sleepiness scale: minimum clinically important difference in obstructive sleep apnea. Am J Respir Crit Care Med 2018; 197: 961–963. 2017/09/30.
Google Scholar | Crossref | Medline25. Puhan, MA, Frey, M, Buchi, S, et al. The minimal important difference of the hospital anxiety and depression scale in patients with chronic obstructive pulmonary disease. Health Qual Life Outcomes 2008; 6: 46. 2008/07/04.
Google Scholar | Crossref | Medline | ISI26. Yang, M, Morin, CM, Schaefer, K, et al. Interpreting score differences in the insomnia severity index: using health-related outcomes to define the minimally important difference. Curr Med Res Opin 2009; 25: 2487–2494. 2009/08/20.
Google Scholar | Crossref | Medline27. Zhdanova, IV, Wurtman, RJ, Balcioglu, A, et al. Endogenous melatonin levels and the fate of exogenous melatonin: age effects. J Gerontol A Biol Sci Med Sci 1998; 53: B293–B298. 2008/03/05.
Google Scholar | Crossref | Medline28. Attarian, H . Importance of sleep in the quality of life of multiple sclerosis patients: a long under-recognized issue. Sleep Med 2009; 10: 7–8. 2008/05/17.
Google Scholar | Crossref | Medline | ISI29. Rossignol, DA, Frye, RE. Melatonin in autism spectrum disorders. Curr Clin Pharmacol 2014; 9: 326–334. 2013/09/21.
Google Scholar | Crossref | Medline30. van Geijlswijk, IM, Korzilius, HP, Smits, MG. The use of exogenous melatonin in delayed sleep phase disorder: a meta-analysis. Sleep 2010; 33: 1605–1614. 2010/12/02.
Google Scholar | Crossref | Medline | ISI31. Jean-Louis, G, Kripke, DF, Cole, RJ, et al. Sleep detection with an accelerometer actigraph: comparisons with polysomnography. Physiol Behav 2001; 72: 21–28. 2001/03/10.
Google Scholar | Crossref | Medline32. Romeo, AR, Rowles, WM, Schleimer, ES, et al. An electronic, unsupervised patient-reported expanded disability status scale for multiple sclerosis. Mult Scler 2020; 27: 1432–1441. 2020/11/26. DOI: 10.1177/1352458520968814
Google Scholar | SAGE Journals33. Brass, SD, Duquette, P, Proulx-Therrien, J, et al. Sleep disorders in patients with multiple sclerosis. Sleep Med Rev 2010; 14: 121–129. 2009/11/03.
Google Scholar | Crossref | Medline34. Cote, I, Trojan, DA, Kaminska, M, et al. Impact of sleep disorder treatment on fatigue in multiple sclerosis. Mult Scler 2013; 19: 480–489. 2012/08/24.
Google Scholar | SAGE Journals | ISI35. Eldadah, BA . Fatigue and fatigability in older adults. PM R 2010; 2: 406–413. 2010/07/27.
Google Scholar | Crossref | Medline36. Bakshi, R . Fatigue associated with multiple sclerosis: diagnosis, impact and management. Mult Scler 2003; 9: 219–227. 2003/06/20.
Google Scholar | SAGE Journals | ISI37. Gooley, JJ, Chamberlain, K, Smith, KA, et al. Exposure to room light before bedtime suppresses melatonin onset and shortens melatonin duration in humans. J Clin Endocrinol Metab 2011; 96: E463–E472. 2011/01/05.
Google Scholar | Crossref | Medline | ISI38. Peuhkuri, K, Sihvola, N, Korpela, R. Diet promotes sleep duration and quality. Nutr Res 2012; 32: 309–319. 2012/06/02.
Google Scholar | Crossref | Medline | ISI39. Hossain, JL, Ahmad, P, Reinish, LW, et al. Subjective fatigue and subjective sleepiness: two independent consequences of sleep disorders? J Sleep Res 2005; 14: 245–253. 2005/08/27.
Google Scholar | Crossref | Medline | ISI40. Merkelbach, S . Schulz H and fatigue collaborative study G. What have fatigue and sleepiness in common? J Sleep Res 2006; 15: 105–106. 2006/02/24.
Google Scholar | Crossref | Medline | ISI41. Paparrigopoulos, T, Ferentinos, P, Kouzoupis, A, et al. The neuropsychiatry of multiple sclerosis: focus on disorders of mood, affect and behaviour. Int Rev Psychiatry 2010; 22: 14–21. 2010/03/18.
Google Scholar | Crossref | Medline | ISI42. Aldughmi, M, Huisinga, J, Lynch, SG, et al. The relationship between fatigability and sleep quality in people with multiple sclerosis. Mult Scler J Exp Transl Clin 2016; 2: 2055217316682774. 2017/06/14.
Google Scholar | SAGE Journals43. Terry, PC, Parsons-Smith, RL, Terry, VR. Mood responses associated With COVID-19 restrictions. Front Psychol 2020; 11: 589598. 2020/12/15.
Google Scholar | Crossref | Medline44. Jacobsen, GD, Jacobsen, KH. Statewide COVID-19 stay-at-home orders and population mobility in the United States. World Med Health Policy 2020; 12(4): 347–356. 2020/08/25. Doi: 10.1002/wmh3.350
Google Scholar | Crossref

Comments (0)

No login
gif